A5004132064- Head and Neck Surgical Oncology
- Thyroid Cancer Diagnosis and Treatment
- Oral and Maxillofacial Pathology
- Salivary Gland Tumors Diagnosis and Treatment
- Head and Neck Cancer Studies
- Thyroid and Parathyroid Surgery
- Head and Neck Anomalies
- Soft tissue tumor case studies
- Tumors and Oncological Cases
- COVID-19 and healthcare impacts
- Bone Tumor Diagnosis and Treatments
- Tracheal and airway disorders
- Ear and Head Tumors
- Sinusitis and nasal conditions
- Infection Control and Ventilation
- Myasthenia Gravis and Thymoma
- Neurofibromatosis and Schwannoma Cases
- Cleft Lip and Palate Research
- Hearing Loss and Rehabilitation
- Pituitary Gland Disorders and Treatments
- Noise Effects and Management
- Hearing, Cochlea, Tinnitus, Genetics
- BRCA gene mutations in cancer
- Reconstructive Surgery and Microvascular Techniques
- Long-Term Effects of COVID-19
Tan Tock Seng Hospital
2016-2025
National Centre for Infectious Diseases
2024
Singapore General Hospital
2007-2024
Changi General Hospital
2024
National University Hospital
2024
Mount Elizabeth Novena Hospital
2024
Sengkang General Hospital
2024
Khoo Teck Puat Hospital
2024
Guy's and St Thomas' NHS Foundation Trust
2021-2023
Evelina London Children's Healthcare
2021-2023
Patients with human papillomavirus (HPV)-related oropharyngeal cancer (OPC) generally present more advanced disease but have better survival than patients HPV-unrelated OPC. The current American Joint Commission on Cancer (AJCC)/Union for International Control (UICC) TNM staging system OPC was developed A new is needed to adequately predict outcomes of HPV-related OPC.Patients newly diagnosed HPV-positive (by p16 immunohistochemistry or in situ hybridization) treated at our institution from...
Background: Obstructive Sleep Apnea (OSA) is a prevalent sleep disorder characterized by intermittent upper airway obstruction, leading to significant health consequences. Traditional diagnostic methods, such as polysomnography, are time-consuming and resource-intensive. Objectives: This study explores the potential of proton-transfer-reaction mass spectrometry (PTR-MS) in identifying volatile organic compound (VOC) biomarkers for non-invasive detection OSA. Methods: Breath samples from 89...
Objectives The Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) categorizes fine needle aspiration and cytology (FNAC) results into 6 tiers assigns a risk of malignancy (ROM) to each category. Its utility in submandibular gland lesions remains unclear. Our article aims study (1) the MSRSGC classifying FNAC masses, (2) describe demographics incidence our population, (3) analyze accuracy diagnosis benign malignant tumors. Methods In this retrospective case series, 92 patients...
Abstract Background In human papillomavirus (HPV)‐associated oropharyngeal squamous cell carcinoma (SCC), reported rates of HPV integration into the host genome vary. Among patients with SCC, we determined differences in demographic, clinical, and survival characteristics between those integrated episomal HPV. Methods The analysis included newly diagnosed SCC presenting to one institution during 1996 2011. HPV‐positive samples were classified according physical state as integrated, episomal,...
To investigate the prevalence and epidemiological risk factors of olfactory and/or taste disorder (OTD), in particular isolated OTD, patients with laboratory-confirmed COVID-19 infection. We conducted a retrospective cross-sectional study. Patients infection were recruited from National Centre for Infectious Diseases (NCID) Singapore between 24 March 2020 16 April 2020. The electronic health records these accessed, demographic data symptoms reported (respiratory, self-reported OTD other such...
The recently described Milan system provides a unified way of categorizing salivary gland fine-needle aspiration (FNA) cytology. We aim to use this stratify risk malignancy in parotid FNAs.In retrospective case series, 376 FNAs were preoperatively performed for 573 parotidectomies over 14 years.Risk on FNA is as follows: nondiagnostic 14.5%, non-neoplastic 26.7%, atypia undetermined significance 29.3%, benign neoplasm 2.7%, uncertain malignant potential 19.1%, suspicious 87.5%, and 100%....
A young woman in her early 30s presented with a right thyroid mass and progressive hoarseness due to vocal cord palsy. The preoperative fine-needle aspiration cytology was classified as Bethesda V she underwent total thyroidectomy neck dissection. Intraoperatively, the adherent oesophagus, trachea encasing recurrent laryngeal nerve which sacrificed. Final histopathology diagnosed rare subtype of cancer known intrathyroidal thymic carcinoma (ITC). She then sent for adjuvant radiotherapy after...
Introduction: The aim of this study was to determine the prevalence hearing loss amongst elderly population attending community services in Singapore. usefulness Hearing Handicap Inventory for Elderly Screening version (HHIE-S) detecting also investigated. Materials and Methods: Pure-tone audiometry carried out on a randomly recruited cohort people (n = 338) over 60 years old who were rehabilitation social day care senior citizens at St Luke’s Elder Care centres located throughout city....
<h3>Abstract</h3> <b>Overview of:</b> Holt A, Blanche P, Zareini B, <i>et al</i>. Gastrointestinal bleeding risk following concomitant treatment with oral glucocorticoids in patients on non-vitamin K anticoagulants. <i>Heart</i>. doi:10.1136/heartjnl-2021-319503 [Epub ahead of print 13 Aug 2021].
Abstract Background Most thyroid nodules are benign. It is important to determine the likelihood of malignancy in such avoid unnecessary surgery. The primary objective this study was characterize genetic landscape and performance a multigene genomic classifier fine‐needle aspiration (FNA) biopsies cytologically indeterminate Southeast Asian cohort. secondary assess predictive contribution clinical characteristics malignancy. Methods This prospective, multicenter, blinded included 132...
This study compared the otoacoustic emissions amplitudes of Asian youths at risk leisure noise exposure through use portable music players with their less exposed counterparts.A listening habit survey was conducted. Subjects were divided into two groups for analysis. A subject placed within high group if he/she reported to near maximum volume and had a physical measurement his/her preferred level recorded > 85 dBA. DPOAE TEOAE levels measured between groups.A total 1928 students from...
Abstract Background The COVID-19 pandemic has had a devastating impact on multiple aspects of healthcare, but also triggered new ways working, stimulated novel approaches in clinical research and reinforced the value previous innovations. Conect4children (c4c, www.conect4children.org ) is large collaborative European network to facilitate development medicines for paediatric populations, made up 35 academic 10 industry partners from 20 countries, more than 50 third parties, around 500...
ABSTRACT Cetuximab immunotherapy targeting the epidermal growth factor receptor (EGFR) has been used to treat nasopharyngeal cancer (NPC) with some success. Therefore, combining an immune adjuvant boost microenvironment may improve its clinical efficacy. Herein, we investigate immune-stimulatory effects of Poly-ICLC (a TLR3 agonist) in enhancing cetuximab-based and correlate these responses FcɣRIIIa (V158F) or single nucleotide polymorphisms (SNPs- L412F C829T) expressed on effector cells....
Research data are not shared.
Bismuth iodoform paraffin paste (BIPP) gauze is widely used as an antiseptic wound packing in otolaryngology, head, and neck surgery. Uncommonly, BIPP can cause intoxication. Our report highlights elderly patient who developed encephalopathy overt myoclonus after nasopharyngectomy secondary to intoxication by the components of gauze. The patient's impaired renal function, amount extensive nature his likely predisposed him toxicity. delirium resolved promptly removal packs. Clinicians should...
A 42-year-old man with multiple comorbidities, including gout, presented to the emergency department severe odynophagia for 4 days intermittent dysphagia 1-2 months. CT scan of neck showed right longus colli tendinitis and partially calcified excrescences from thyroid cartilage which raised suspicion a cartilaginous tumour. He underwent an MRI better evaluate findings, heterogeneous mass suspicious chondroid then positron-emission tomography-CT fluorodeoxyglucose-avid containing foci...