A5071297179- Bacterial Genetics and Biotechnology
- Thyroid Cancer Diagnosis and Treatment
- Escherichia coli research studies
- Diabetes Management and Research
- Bacteriophages and microbial interactions
- Thyroid and Parathyroid Surgery
- Genomics and Phylogenetic Studies
- Hernia repair and management
- Medical Imaging and Pathology Studies
- Parathyroid Disorders and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Diabetes Management and Education
- Diabetes Treatment and Management
- Gastric Cancer Management and Outcomes
- Chronic Disease Management Strategies
- RNA and protein synthesis mechanisms
- Metabolism, Diabetes, and Cancer
- Head and Neck Anomalies
- Mobile Health and mHealth Applications
- Metastasis and carcinoma case studies
- Cardiac, Anesthesia and Surgical Outcomes
- Digital Mental Health Interventions
- Abdominal Surgery and Complications
- Thyroid Disorders and Treatments
- BRCA gene mutations in cancer
National University of Singapore
2005-2025
Singapore Centre for Environmental Life Sciences Engineering
2018-2025
Singapore General Hospital
2014-2024
National University Hospital
2009-2024
SingHealth Polyclinics
2024
SingHealth
2022
University of Manitoba
2018-2021
National University Health System
2015-2019
Ng Teng Fong General Hospital
2018
University of Teacher Education Lucerne
2018
Randomized trials demonstrated a lower risk of cardiovascular (CV) events with sodium-glucose cotransporter-2 inhibitors (SGLT-2i) in patients type 2 diabetes (T2D) at high CV risk. Prior real-world data suggested similar SGLT-2i effects T2D broader profile, but these studies focused on heart failure and death were limited to the United States Europe.The purpose this study was examine broad range outcomes initiated versus other glucose-lowering drugs (oGLDs) across 6 countries Asia Pacific,...
<h3>Importance</h3> Multimorbidity is a growing health care problem in aging societies and strongly associated with epidemiologic characteristics sociodemographic factors. Knowledge of these associations important for the design effective preventive management strategies. <h3>Objectives</h3> To determine association between multimorbidity factors (age, socioeconomic status [SES], sex, race/ethnicity) mental diseases physical diseases, as well their implications types costs use. <h3>Design,...
BACKGROUND The Bethesda System for Reporting Thyroid Cytopathology is the most widely used classification system reporting of thyroid fine‐needle aspiration cytology (FNAC) specimens. However, “atypical” category (“atypia undetermined significance” [AUS] or “follicular lesion [FLUS]) continues to cause diagnostic and therapeutic dilemmas. objectives this study were describe differential malignancy rates FNACs diagnosed as AUS/FLUS based on nuclear architectural atypia assess significance...
Gram-negative bacteria are defined by an outer membrane (OM) that contributes to envelope integrity and barrier function. Building this bilayer require proper assembly of lipopolysaccharides, proteins, phospholipids, yet how the balance these components is achieved unclear. One system long known for ensuring OM stability Tol-Pal complex, which has been implicated in maintaining lipid homeostasis. However, assignment function challenging, owing its septal localization associated role(s)...
Chitosan nanobead encapsulation of quantum dots (QDs) produces water-soluble, stable fluorescent markers for biomedical imaging. As shown in the Figure, derivatization QDs with 3-mercaptopropionic acid (3MPA) a negatively charged surface to which positively chitosan is electrostatically attracted. MRI contrast agents such as Gd-DTPA can also be incorporated into nanobeads, are small enough individual cells.
The cell envelope is essential for viability in all domains of life. It retains enzymes and substrates within a confined space while providing protective barrier to the external environment. Destabilising bacterial pathogens common strategy employed by antimicrobial treatment. However, even one best studied organisms, Escherichia coli, there remain gaps our understanding how synthesis successive layers are coordinated during growth division. Here, we used whole-genome phenotypic screen...
Background: Molecular testing (MT) is commonly used to refine cancer probability in thyroid nodules with indeterminate cytology. Whether or not ultrasound (US) patterns and clinical parameters can further inform the risk of predicted be positive negative by MT remains unknown. The aim this study was test if parameters, including patient age, sex, nodule size (by US), Bethesda category (III, IV, V), US pattern (American Thyroid Association [ATA] vs. American College Radiology Image Reporting...
Introduction Diabetes and hypertension are prevalent costly to the health system. We have developed a mobile app (EMPOWER app) which enables remote monitoring education through personalised nudges. aim study effectiveness of multi-component intervention comprising EMPOWER with coaching shared decision-making for diabetes hypertension. Methods will conduct two-arm, open-label, pragmatic randomised controlled trial (RCT). Participants comorbid enrolled from public primary care clinics be...
Background: Although The Bethesda System for Reporting Thyroid Cytopathology has provided clinicians with a standardized classification scheme the diagnosis of thyroid fine-needle aspiration cytology (FNAC) specimens, indeterminate categories III (B3)—atypia undetermined significance/follicular lesion significance (AUS/FLUS)—and IV (B4)—follicular neoplasm/suspicious follicular neoplasm (FN/SFN)—continue to pose challenges regards ideal diagnostic and therapeutic management. Having...
Abstract Background Randomized, controlled cardiovascular outcome trials may not be fully representative of the management patients with type 2 diabetes across different geographic regions. We conducted analyses data from multinational CVD-REAL consortium to determine association between initiation sodium–glucose cotransporter-2 inhibitors (SGLT-2i) and outcomes, including subgroup based on patient characteristics. Methods De-identified health records 13 countries three continents were used...
(1) Introduction: The ubiquity of mobile phones suggests the potential health applications to reach patients with type 2 diabetes and engage them improve self-care. This study aimed explore personal goals, barriers self-management desired application features self-care among multi-ethnic Asian diabetes. (2) Methods: We conducted semi-structured interviews (
Peptidoglycan (PG) is an extracytoplasmic glycopeptide matrix essential for the integrity of envelope most bacteria. The PG building block a disaccharide-pentapeptide that synthesized as lipid-linked precursor called lipid II. translocation amphipathic II across cytoplasmic membrane required subsequent incorporation into PG. In Escherichia coli, inner protein MurJ flippase. Previous studies showed 8 charged residues in central cavity region are crucial function. Here, we completed functional...
Introduction Type 2 diabetes mellitus (T2DM) poses huge burden and cost on the healthcare system. Mobile health (mHealth) interventions that incorporate wearables may be able to improve self-management. The aim of this randomized controlled trial (RCT) is investigate clinical cost-effectiveness personalized educational behavioral delivered through an EMPOWER mobile application (app) among patients with T2DM. Methods This a parallel two-arm (RCT). Patients T2DM recruited from primary care...
Objective We conducted a cross-sectional study to adapt and validate the Hypoglycemia Fear Survey-II (HFS-II) for use in Singapore among persons with type 1 2 diabetes mellitus. Research design methods A total of 144 patients or on insulin therapy at least year completed HFS-II between September December 2013 Diabetes Center General Hospital. examined validity (content, concurrent discriminant validity, construct validity) reliability (internal consistency test–retest reliability)...
Impaired awareness of hypoglycaemia (IAH) predisposes affected patients to severe hypoglycaemia. There are few data on prevalence IAH in adults with insulin-treated type 2 diabetes Asia. We aim ascertain the among an outpatient clinic a tertiary care centre Singapore.A total 374 attending referral Singapore were recruited over 4-month period. Participants completed questionnaire document baseline characteristics and assess their status, using combination Clarke, Gold Pedersen-Bjergaard...
The outer membrane (OM) is an essential component of the Gram-negative bacterial envelope that protects cells against external threats. To maintain a functional OM, require distinct mechanisms to ensure balance proteins and lipids in membrane. Mutations OM biogenesis and/or homeostasis pathways often result permeability defects, but how molecular changes affect barrier function unclear. Here, we seek potential mechanism(s) can alleviate defects Escherichia coli lacking Tol-Pal complex, which...
Abstract Background Most thyroid nodules are benign. It is important to determine the likelihood of malignancy in such avoid unnecessary surgery. The primary objective this study was characterize genetic landscape and performance a multigene genomic classifier fine‐needle aspiration (FNA) biopsies cytologically indeterminate Southeast Asian cohort. secondary assess predictive contribution clinical characteristics malignancy. Methods This prospective, multicenter, blinded included 132...
Abstract Gram-negative bacteria are defined by an outer membrane (OM) that contributes to envelope integrity and barrier function. Building this bilayer require proper assembly of lipopolysaccharides, proteins, phospholipids, yet how the balance these components is achieved unclear. One system long known for ensuring OM stability Tol-Pal complex, which has been implicated in maintaining lipid homeostasis. However, assignment function challenging, owing its septal localization associated...