A5040146992- Renal Transplantation Outcomes and Treatments
- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Diet and metabolism studies
- Bariatric Surgery and Outcomes
- Colorectal Cancer Surgical Treatments
- Diverticular Disease and Complications
- Biliary and Gastrointestinal Fistulas
- Gastrointestinal disorders and treatments
- Endometriosis Research and Treatment
- Nutritional Studies and Diet
- Esophageal and GI Pathology
- Atrial Fibrillation Management and Outcomes
- Liver Diseases and Immunity
- Uterine Myomas and Treatments
- Statistical Methods in Clinical Trials
- Acute Ischemic Stroke Management
- Thyroid Cancer Diagnosis and Treatment
- Ovarian cancer diagnosis and treatment
- Anorectal Disease Treatments and Outcomes
- Neuroendocrine Tumor Research Advances
- Head and Neck Anomalies
- Gastrointestinal Tumor Research and Treatment
- Gastric Cancer Management and Outcomes
- Minimally Invasive Surgical Techniques
Ng Teng Fong General Hospital
2020-2025
National University Hospital
2018-2023
National University Health System
2018-2020
National University of Singapore
2017
BACKGROUND The Bethesda System for Reporting Thyroid Cytopathology is the most widely used classification system reporting of thyroid fine‐needle aspiration cytology (FNAC) specimens. However, “atypical” category (“atypia undetermined significance” [AUS] or “follicular lesion [FLUS]) continues to cause diagnostic and therapeutic dilemmas. objectives this study were describe differential malignancy rates FNACs diagnosed as AUS/FLUS based on nuclear architectural atypia assess significance...
Abstract Background Standard‐of‐care for warfarin dose titration is conventionally based on physician‐guided drug dosing. This may lead to frequent deviations from target international normalized ratio (INR) due inter‐ and intra‐patient variability potentially result in adverse events including recurrent thromboembolism life‐threatening hemorrhage. Objectives We aim employ CURATE.AI, a small‐data, artificial intelligence‐derived platform that has been clinically validated range of...
Abstract Tacrolimus is the cornerstone of immunosuppressive therapy after pediatric liver transplantation. However, reliance on physician's experience for dose titration, coupled with tacrolimus's narrow therapeutic window and inter‐ intrapatient variability, often results in frequent under or overdosing events detrimental patient outcomes. Existing predictive personalization models are not readily feasible clinical implementation, as they require multiple measurements each day while...
Tacrolimus is a potent immunosuppressant used after pediatric liver transplant. However, tacrolimus's narrow therapeutic window, reliance on physicians' experience for the dose titration, and intra- inter-patient variability result in transplant patients falling out of target tacrolimus trough levels frequently. Existing personalized dosing models based area-under-the-concentration over time curves require higher frequency blood draws than current standard care may not be practically...
Abstract Tacrolimus is the cornerstone of immunosuppressive therapy after pediatric liver transplantation. However, reliance on physician’s experience for dose titration, coupled with tacrolimus’s narrow therapeutic window and inter intra-patient variability, often results in frequent under or over-dosing detrimental patient outcomes. Existing predictive personalization models are not readily feasible clinical implementation, as they require multiple measurements each day while standard...
Background: Despite advances in the medical management of peptic ulcer disease, duodenal (DU) perforation remains a common surgical emergency. Most DU perforations are small and can be managed with omental patch repair. However, occasionally surgeon may encounter giant not amenable to this. Giant defined as > 2cm. They associated high leak rates mortality. Prognosis elderly patients particularly poor because advanced age comorbidities. Furthermore, there no specific recommendations for...
Introduction: A Dieulafoy lesion is a large tortuous submucosal arteriole protruding through small mucosal defect.1 It uncommon but potentially life threatening.2 Endoscopic hemostasis can control bleeding in 90% of patients. Angiography an alternative for inaccessible lesions, surgery required should these options fail.3 Single-port laparoscopic has gained traction recently because faster recovery and better cosmesis versus multiport surgery.4,5 The use “glove-port” also been described...
Background: Living donor liver transplantation (LDLT) has become a gold standard treatment in pediatric end-stage disease.Tacrolimus forms the cornerstone of immunosuppression after LDLT.Standard-of-care for tacrolimus dose titration is conventionally based on physician-guided drug dosing.This, however, leads to frequent deviations from target trough levels due inter-and intra-patient variability, particularly during critical early postoperative phase.Tacrolimus narrow therapeutic index and...