A5081356520- Diabetes Treatment and Management
- Diabetes Management and Research
- Chronic Disease Management Strategies
- COVID-19 Clinical Research Studies
- Metabolism, Diabetes, and Cancer
- COVID-19 and healthcare impacts
- Physical Activity and Health
- Cardiovascular Function and Risk Factors
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Long-Term Effects of COVID-19
- Cardiovascular and exercise physiology
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Health Systems, Economic Evaluations, Quality of Life
- Diet and metabolism studies
- Frailty in Older Adults
- Obesity, Physical Activity, Diet
- Heart Rate Variability and Autonomic Control
- Diabetes and associated disorders
- Pharmacology and Obesity Treatment
- COVID-19 and Mental Health
- Diabetes Management and Education
- SARS-CoV-2 and COVID-19 Research
- Heart Failure Treatment and Management
- Liver Disease Diagnosis and Treatment
- Thermoregulation and physiological responses
Leicester General Hospital
2016-2025
University of Leicester
2016-2025
University Hospitals of Leicester NHS Trust
2016-2025
NIHR Leicester Biomedical Research Centre
2017-2025
NIHR Applied Research Collaboration Greater Manchester
2021-2024
Schauenburg (United Kingdom)
2024
National Institute for Health Research
2018-2023
Leicester College
2023
NIHR Clinical Research Network
2022
Central Finland Health Care District
2022
Abstract Although myocarditis and pericarditis were not observed as adverse events in coronavirus disease 2019 (COVID-19) vaccine trials, there have been numerous reports of suspected cases following vaccination the general population. We undertook a self-controlled case series study people aged 16 or older vaccinated for COVID-19 England between 1 December 2020 24 August 2021 to investigate hospital admission death from myocarditis, cardiac arrhythmias 1–28 days adenovirus (ChAdOx1, n =...
Abstract Objective To estimate associations between covid-19 vaccination and long covid symptoms in adults with SARS-CoV-2 infection before vaccination. Design Observational cohort study. Setting Community dwelling population, UK. Participants 28 356 participants the Office for National Statistics COVID-19 Infection Survey aged 18-69 years who received at least one dose of an adenovirus vector or mRNA vaccine after testing positive infection. Main outcome measure Presence 12 weeks over...
Abstract Emerging reports of rare neurological complications associated with COVID-19 infection and vaccinations are leading to regulatory, clinical public health concerns. We undertook a self-controlled case series study investigate hospital admissions from in the 28 days after first dose ChAdOx1nCoV-19 ( n = 20,417,752) or BNT162b2 12,134,782), SARS-CoV-2-positive test 2,005,280). There was an increased risk Guillain–Barré syndrome (incidence rate ratio (IRR), 2.90; 95% confidence interval...
Abstract Objective To assess the association between covid-19 vaccines and risk of thrombocytopenia thromboembolic events in England among adults. Design Self-controlled case series study using national data on vaccination hospital admissions. Setting Patient level were obtained for approximately 30 million people vaccinated 1 December 2020 24 April 2021. Electronic health records linked with death from Office National Statistics, SARS-CoV-2 positive test data, admission United Kingdom’s...
Whether a healthy lifestyle impacts longevity in the presence of multimorbidity is unclear. We investigated associations between and life expectancy people with without multimorbidity.A total 480,940 middle-aged adults (median age 58 years [range 38-73], 46% male, 95% white) were analysed UK Biobank; this longitudinal study collected data 2006 2010, participants followed up until 2016. extracted 36 chronic conditions defined as 2 or more conditions. Four factors, based on national...
Multimorbidity is an emerging public health priority. Physical activity (PA) recommended as one of the main lifestyle behaviours, yet benefits PA for people with multimorbidity are unclear. We assessed on mortality and life expectancy in without multimorbidity. Using UK Biobank dataset, we extracted data 36 chronic conditions defined (a) 2 or more conditions, (b) combined self-reported overall health, (c) top-10 most common comorbidities. Leisure-time (LTPA) total (TPA) were measured by...
Sauna bathing is a health habit associated with better hemodynamic function; however, the association of sauna cardiovascular and all-cause mortality not known.To investigate frequency duration risk sudden cardiac death (SCD), fatal coronary heart disease (CHD), (CVD), mortality.We performed prospective cohort study (Finnish Kuopio Ischemic Heart Disease Risk Factor Study) population-based sample 2315 middle-aged (age range, 42-60 years) men from Eastern Finland. Baseline examinations were...
To quantify the association of self-reported walking pace and handgrip strength with all-cause, cardiovascular, cancer mortality. A total 230 670 women 190 057 men free from prevalent cardiovascular disease were included UK Biobank. Usual was self-defined as slow, steady/average or brisk. Handgrip assessed by dynamometer. Cox-proportional hazard models adjusted for social deprivation, ethnicity, employment, medications, alcohol use, diet, physical activity, television viewing time....
Background: Myocarditis is more common after severe acute respiratory syndrome coronavirus 2 infection than COVID-19 vaccination, but the risks in younger people and sequential vaccine doses are less certain. Methods: A self-controlled case series study of ages 13 years or older vaccinated for England between December 1, 2020, 15, 2021, evaluated association vaccination myocarditis, stratified by age sex. The incidence rate ratio excess number hospital admissions deaths from myocarditis per...
Background: There are multiple risk factors for heart failure, but contemporary temporal trends according to sex, socioeconomic status, and ethnicity unknown. Methods: Using a national UK general practice database linked hospitalizations (1998–2017), 108 638 incident failure patients were identified. Differences in among patient groups adjusted sociodemographic age-adjusted investigated using logistic linear regression. Results: Over time, 5.3 year (95% CI, 5.2–5.5) age difference between...
We investigated long COVID incidence by vaccination status in a random sample of UK adults from April 2020 to November 2021. Persistent symptoms were reported 9.5% 3090 breakthrough severe acute respiratory syndrome coronavirus 2 infections and 14.6% unvaccinated controls (adjusted odds ratio, 0.59 [95% confidence interval, .50-.69]), emphasizing the need for public health initiatives increase population-level vaccine uptake.
Abstract Background Sarcopenia, a degenerative and generalized skeletal muscle disorder involving the loss of function mass, is an under‐recognized problem in clinical practice, particularly chronic kidney disease (CKD). We aimed to investigate prevalence sarcopenia individuals with CKD, its risk factors, association all‐cause mortality progression end‐stage renal (ESRD). Methods UK Biobank participants were grouped according presence CKD (defined as estimated glomerular filtration rate...