A5041576405- Data Quality and Management
- Child Abuse and Trauma
- Sepsis Diagnosis and Treatment
- COVID-19 and healthcare impacts
- Respiratory Support and Mechanisms
- COVID-19 Clinical Research Studies
- Homelessness and Social Issues
- Cardiac Arrest and Resuscitation
- Intensive Care Unit Cognitive Disorders
- Long-Term Effects of COVID-19
- Platelet Disorders and Treatments
- Vaccine Coverage and Hesitancy
- Venous Thromboembolism Diagnosis and Management
- SARS-CoV-2 and COVID-19 Research
- Data-Driven Disease Surveillance
- Atrial Fibrillation Management and Outcomes
- Emergency and Acute Care Studies
- Blood transfusion and management
- Heparin-Induced Thrombocytopenia and Thrombosis
- Health disparities and outcomes
- Healthcare Policy and Management
- Cardiac electrophysiology and arrhythmias
- Obesity, Physical Activity, Diet
- Chronic Disease Management Strategies
- Homicide, Infanticide, and Child Abuse
Intensive Care National Audit & Research Centre
2019-2024
London School of Hygiene & Tropical Medicine
2021-2023
Oxford University Hospitals NHS Trust
2023
The Recovery Center
2022
University of Oxford
2021
University of South Australia
2012-2021
University College London
2016-2021
Great Ormond Street Hospital
2019-2021
Guy's and St Thomas' NHS Foundation Trust
2021
King's College London
2021
Abstract Emerging reports of rare neurological complications associated with COVID-19 infection and vaccinations are leading to regulatory, clinical public health concerns. We undertook a self-controlled case series study investigate hospital admissions from in the 28 days after first dose ChAdOx1nCoV-19 ( n = 20,417,752) or BNT162b2 12,134,782), SARS-CoV-2-positive test 2,005,280). There was an increased risk Guillain–Barré syndrome (incidence rate ratio (IRR), 2.90; 95% confidence interval...
Abstract Objective To assess the association between covid-19 vaccines and risk of thrombocytopenia thromboembolic events in England among adults. Design Self-controlled case series study using national data on vaccination hospital admissions. Setting Patient level were obtained for approximately 30 million people vaccinated 1 December 2020 24 April 2021. Electronic health records linked with death from Office National Statistics, SARS-CoV-2 positive test data, admission United Kingdom’s...
To describe critical care patients with COVID-19 across England, Wales and Northern Ireland compare them a historic cohort of other viral pneumonias (non-COVID-19) international cohorts COVID-19.Extracted data on patient characteristics, acute illness severity, organ support outcomes from the Case Mix Programme, national clinical audit for adult care, prospective (February to August 2020) are compared recent retrospective (2017-2019) COVID-19, latter identified published reports.10,834...
Rationale: By describing trends in intensive care for patients with coronavirus disease (COVID-19) we aim to support clinical learning, service planning, and hypothesis generation.Objectives: To describe variation ICU admission rates over time by geography during the first wave of epidemic England, Wales, Northern Ireland; patient characteristics on ICU, first-24-hours physiology processes outcomes; explore deviations peak period.Methods: A cohort 10,741 COVID-19 Case Mix Program national...
Linked datasets are an important resource for epidemiological and clinical studies, but linkage error can lead to biased results. For data security reasons, of personal identifiers is often performed by a third party, making it difficult researchers assess the quality linked dataset in context specific research questions. This compounded lack guidance on how determine potential impact error. We describe be evaluated provide widely applicable both providers researchers. Using illustrative...
OBJECTIVES: To identify characteristics that predict 30-day mortality among patients critically ill with coronavirus disease 2019 in England, Wales, and Northern Ireland. DESIGN: Observational cohort study. SETTING: A total of 258 adult critical care units. PATIENTS: 10,362 confirmed a start between March 1, 2020, June 22, whom 9,990 were eligible (excluding duration less than 24 hr or missing core variables). MEASUREMENTS AND MAIN RESULTS: The main outcome measure was time to death within...
OBJECTIVES: To determine whether patients admitted to an ICU during times of unprecedented capacity strain, the COVID-19 pandemic in United Kingdom, experienced a higher risk death. DESIGN: Multicenter, observational cohort study using routine clinical audit data. SETTING: Adult general ICUs participating Intensive Care National Audit & Research Centre Case Mix Programme England, Wales, and Northern Ireland. PATIENTS: One-hundred thirty-thousand six-hundred eighty-nine 210 adult 207...
Abstract Several studies have reported associations between COVID-19 vaccination and risk of cardiac diseases, especially in young people; the impact on mortality, however, remains unclear. We use national, linked electronic health data England to assess positive SARS-CoV-2 tests all-cause mortality people (12 29 years) using a self-controlled case series design. Here, we show there is no significant increase or 12 weeks following compared more than after any dose. However, find an death...
Background: In the United Kingdom, around 184,000 adults are admitted to an intensive care unit (ICU) each year with over 30% receiving mechanical ventilation. Oxygen is commonest therapeutic intervention provided these patients but it unclear how much oxygen should be administered for best clinical outcomes. Methods: The UK-ROX trial will evaluate and cost-effectiveness of conservative therapy (the minimum concentration required maintain saturation 90% ± 2%) versus usual in critically ill...
Child maltreatment (CM) is a global public health issue, with reported impacts on and social outcomes. Evidence mortality lacking. In this study, we aimed to estimate the impact of CM death rates in persons 16 33 years.A retrospective cohort study all born South Australia 1986 2003 using linked administrative data. exposure was based child protection service (CPS) contact: unexposed, no CPS contact before years, 7 exposed groups. Deaths were observed until May 31, 2019 plotted from years....
Linked data are increasingly being used for epidemiological research, to enhance primary and in planning, monitoring evaluating public policy services. Linkage error (missed links between records that relate the same person or false unrelated records) can manifest many ways: as missing data, measurement misclassification, unrepresentative sampling, a special combination of these is specific analysis linked data: merging splitting people occur when two hospital admission counted one admitted...
Early in a pandemic, outcomes are biased towards patients with shorter durations of critical illness. We describe 60-day for critically ill confirmed COVID-19 and explore the potential bias weekly reported data by ICNARC.First 200 consecutive COVID-19, admitted care England, Wales Northern Ireland, followed-up minimum 60 days from admission. Outcomes included survival duration care, receipt/duration organ support hospital survival.Mean age was 62.6 years, 70.5% were male, 52.0% white, 39.2%...
Abstract Background New-onset atrial fibrillation (NOAF) in patients treated on an intensive care unit (ICU) is common and associated with significant morbidity mortality. We undertook a systematic scoping review to summarise comparative evidence inform NOAF management for admitted ICU. Methods searched MEDLINE, EMBASE, CINAHL, Web of Science, OpenGrey, Cochrane Database Systematic Reviews, Central Register Controlled Trials, Abstracts Reviews Effects, ISRCTN, ClinicalTrials.gov, EU Clinical...
Hypotension following out-of-hospital cardiac arrest (OHCA) may cause secondary brain injury and increase mortality rates. Current guidelines recommend avoiding hypotension. However, the optimal blood pressure OHCA is unknown. We hypothesised that exposure to hypotension hypertension in first 24 h ICU would be associated with OHCA.We conducted a retrospective analysis of patients included Intensive Care National Audit Research Centre Case Mix Programme from 1 January 2010 31 December 2019....
New-onset atrial fibrillation (NOAF) is common in patients treated on an intensive care unit (ICU), but the long-term impacts patient outcomes are unclear. We compared national hospital and of who developed NOAF ICU with those did not, before after adjusting for comorbidities admission factors.Using RISK-II database (Case Mix Programme clinical audit adult linked Hospital Episode Statistics mortality data), we conducted a retrospective cohort study 4615 27 690 matched controls admitted to...
Background: Linkage of administrative data sources provides an efficient means collecting detailed on how individuals interact with cross-sectoral services, society, and the environment. These can be used to supplement conventional cohort studies, or create population-level electronic cohorts generated solely from data. However, errors occurring during linkage (false matches/missed matches) lead bias in results linked data.Aim: This paper guidance evaluating quality studies.Methods: We...
Rationale: Examining trends in patient characteristics, processes of care and outcomes, across an epidemic, provides important opportunities for learning. Objectives: To report explore changes admission rates, outcomes all patients with COVID-19 admitted to intensive units (ICUs) England, Wales Northern Ireland. Methods: Population cohort 10,287 the Case Mix Programme national clinical audit from 1 February 2 July, 2020. Analyses were stratified by time period (pre-peak, peak, post-peak)...