A5080823270- Injury Epidemiology and Prevention
- Traffic and Road Safety
- Emergency and Acute Care Studies
- COVID-19 Clinical Research Studies
- Health Systems, Economic Evaluations, Quality of Life
- Trauma and Emergency Care Studies
- COVID-19 and Mental Health
- SARS-CoV-2 and COVID-19 Research
- Lipoproteins and Cardiovascular Health
- Bone health and osteoporosis research
- Long-Term Effects of COVID-19
- Colorectal Cancer Screening and Detection
- Chronic Disease Management Strategies
- Primary Care and Health Outcomes
- COVID-19 and healthcare impacts
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Inflammatory mediators and NSAID effects
- Cardiac Health and Mental Health
- Influenza Virus Research Studies
- Cancer Risks and Factors
- Blood Pressure and Hypertension Studies
- Global Cancer Incidence and Screening
- Healthcare Policy and Management
- Health disparities and outcomes
- Vaccine Coverage and Hesitancy
University of Nottingham
2016-2025
University of Oxford
2020-2025
Primary HealthCare
2021-2023
Primary Health Care
2021-2023
Nottingham Biomedical Research Centre
2023
National Institute for Health Research
2023
Nottingham University Hospitals NHS Trust
2010-2023
German Center for Diabetes Research
2023
Heinrich Heine University Düsseldorf
2023
Deutsches Diabetes-Zentrum e.V.
2023
<b>Objective</b> To develop and validate version two of the QRISK cardiovascular disease risk algorithm (QRISK2) to provide accurate estimates in patients from different ethnic groups England Wales compare its performance with modified Framingham score recommended by National Institute for Health Clinical Excellence (NICE). <b>Design</b> Prospective open cohort study routinely collected data general practice, 1 January 1993 31 March 2008. <b>Setting</b> 531 practices contributing national...
<b>Objectives</b> To develop and validate updated QRISK3 prediction algorithms to estimate the 10 year risk of cardiovascular disease in women men accounting for potential new factors. <b>Design</b> Prospective open cohort study. <b>Setting</b> General practices England providing data QResearch database. <b>Participants</b> 1309 general England: 981 were used scores a separate set 328 scores. 7.89 million patients aged 25-84 years derivation 2.67 validation cohort....
<b>Objective</b> To derive a new cardiovascular disease risk score (QRISK) for the United Kingdom and to validate its performance against established Framingham algorithm newly developed Scottish (ASSIGN). <b>Design</b> Prospective open cohort study using routinely collected data from general practice. <b>Setting</b> UK practices contributing QRESEARCH database. <b>Participants</b> The derivation consisted of 1.28 million patients, aged 35-74 years, registered at 318 between 1 January 1995...
<b>Objectives</b> To investigate the association between antidepressant treatment and risk of several potential adverse outcomes in older people with depression to examine risks by class antidepressant, duration use, dose. <b>Design</b> Cohort study aged 65 over diagnosed as having depression. <b>Setting</b> 570 general practices United Kingdom supplying data QResearch primary care database. <b>Participants</b> 60 746 patients a new episode ages 100 years from 1 January 1996 31 December 2007...
To determine the comparative risk of myocardial infarction in patients taking cyclo-oxygenase-2 and other non-steroidal anti-inflammatory drugs (NSAIDs) primary care between 2000 2004; to these risks with without pre-existing coronary heart disease those not aspirin.
To derive and validate a risk prediction algorithm to estimate hospital admission mortality outcomes from coronavirus disease 2019 (covid-19) in adults.Population based cohort study.QResearch database, comprising 1205 general practices England with linkage covid-19 test results, Hospital Episode Statistics, death registry data. 6.08 million adults aged 19-100 years were included the derivation dataset 2.17 validation dataset. The first period was 24 January 2020 30 April 2020. second...
Abstract Although myocarditis and pericarditis were not observed as adverse events in coronavirus disease 2019 (COVID-19) vaccine trials, there have been numerous reports of suspected cases following vaccination the general population. We undertook a self-controlled case series study people aged 16 or older vaccinated for COVID-19 England between 1 December 2020 24 August 2021 to investigate hospital admission death from myocarditis, cardiac arrhythmias 1–28 days adenovirus (ChAdOx1, n =...
<b>Objective</b> To quantify the unintended effects of statins according to type, dose, and duration use. <b>Design</b> Prospective open cohort study using routinely collected data. <b>Setting</b> 368 general practices in England Wales supplying data QResearch database. <b>Participants</b> 2 004 692 patients aged 30-84 years whom 225 922 (10.7%) were new users statins: 159 790 (70.7%) prescribed simvastatin, 50 328 (22.3%) atorvastatin, 8103 (3.6%) pravastatin, 4497 (1.9%) rosuvastatin, 3204...
Anticholinergic medicines have short-term cognitive adverse effects, but it is uncertain whether long-term use of these drugs associated with an increased risk dementia.To assess associations between anticholinergic drug treatments and dementia in persons 55 years or older.This nested case-control study took place general practices England that contributed to the QResearch primary care database. The evaluated exposure was 58 769 patients a diagnosis 225 574 controls older matched by age,...
<b>Objective</b> To develop and validate two new fracture risk algorithms (QFractureScores) for estimating the individual of osteoporotic or hip over 10 years. <b>Design</b> Prospective open cohort study with routinely collected data from 357 general practices to scores 178 scores. <b>Setting</b> General in England Wales. <b>Participants</b> 1 183 663 women 174 232 men aged 30-85 derivation cohort, who contributed 7 898 208 8 049 306 person years observation, respectively. There were 24 350...
<b>Objective</b> To develop and validate a new diabetes risk algorithm (the QDScore) for estimating 10 year of acquiring diagnosed type 2 over time period in an ethnically socioeconomically diverse population. <b>Design</b> Prospective open cohort study using routinely collected data from 355 general practices England Wales to the score 176 separate score. <b>Participants</b> 540 753 patients aged 25-79 derivation cohort, who contributed 16 436 135 person years observation whom 78 081 had...
There is uncertainty about the associations of angiotensive enzyme (ACE) inhibitor and angiotensin receptor blocker (ARB) drugs with COVID-19 disease. We studied whether patients prescribed these had altered risks contracting severe disease receiving associated intensive care unit (ICU) admission.
<h3>BACKGROUND AND PURPOSE:</h3> Inflammation and degeneration of the intracranial saccular aneurysm wall play a major role in formation, development subsequent rupture. The aim this study was to characterize walls unruptured aneurysms by using hybrid opposite-contrast MRA at 3T. <h3>MATERIALS METHODS:</h3> Fourteen consecutive patients with 17 who initially underwent clipping surgery were prospectively evaluated. All scanned preoperatively 3T high-resolution MR imaging. We classified...
To develop and validate an updated version of the QFracture algorithm for estimating risk a patient sustaining osteoporotic fracture or hip in primary care population.Prospective open cohort study using routinely collected data from 420 general practices United Kingdom to scores 207 scores. Cox's proportional hazards model was used derivation derive equations several explanatory variables. We calculated measures calibration discrimination validation cohort.3,142,673 patients 1,583,373...
Abstract Emerging reports of rare neurological complications associated with COVID-19 infection and vaccinations are leading to regulatory, clinical public health concerns. We undertook a self-controlled case series study investigate hospital admissions from in the 28 days after first dose ChAdOx1nCoV-19 ( n = 20,417,752) or BNT162b2 12,134,782), SARS-CoV-2-positive test 2,005,280). There was an increased risk Guillain–Barré syndrome (incidence rate ratio (IRR), 2.90; 95% confidence interval...
Abstract Objective To assess the association between risk of venous thromboembolism and use different types hormone replacement therapy. Design Two nested case-control studies. Setting UK general practices contributing to QResearch or Clinical Practice Research Datalink (CPRD) databases, linked hospital, mortality, social deprivation data. Participants 80 396 women aged 40-79 with a primary diagnosis 1998 2017, matched by age, practice, index date 391 494 female controls. Main outcome...
Objectives Previous pandemics have resulted in significant consequences for mental health. Here, we report the health sequelae of COVID-19 pandemic a UK cohort and examine modifiable non-modifiable explanatory factors associated with outcomes. We focus on first wave data collection, which examined short-term health, as reported during 4–6 weeks social distancing measures being introduced. Design Cross-sectional online survey. Setting Community study. Participants N=3097 adults aged ≥18 years...
Abstract Objective To assess the association between covid-19 vaccines and risk of thrombocytopenia thromboembolic events in England among adults. Design Self-controlled case series study using national data on vaccination hospital admissions. Setting Patient level were obtained for approximately 30 million people vaccinated 1 December 2020 24 April 2021. Electronic health records linked with death from Office National Statistics, SARS-CoV-2 positive test data, admission United Kingdom’s...
Abstract Objectives To derive and validate risk prediction algorithms to estimate the of covid-19 related mortality hospital admission in UK adults after one or two doses vaccination. Design Prospective, population based cohort study using QResearch database linked data on vaccination, SARS-CoV-2 results, admissions, systemic anticancer treatment, radiotherapy, national death cancer registries. Settings Adults aged 19-100 years with vaccination between 8 December 2020 15 June 2021. Main...
<h3>Abstract</h3> <h3>Objective</h3> To investigate the associations between direct oral anticoagulants (DOACs) and risks of bleeding, ischaemic stroke, venous thromboembolism, all cause mortality compared with warfarin. <h3>Design</h3> Prospective open cohort study. <h3>Setting</h3> UK general practices contributing to QResearch or Clinical Practice Research Datalink. <h3>Participants</h3> 132 231 warfarin, 7744 dabigatran, 37 863 rivaroxaban, 18 223 apixaban users without anticoagulant...
SummaryBackgroundPrevious studies suggested that the prevalence of chronic respiratory disease in patients hospitalised with COVID-19 was lower than its general population. The aim this study to assess whether lung or use inhaled corticosteroids (ICS) affects risk contracting severe COVID-19.MethodsIn population cohort study, records from 1205 practices England contribute QResearch database were linked Public Health England's SARS-CoV-2 testing and English hospital admissions, intensive care...
<b>Objective</b> To investigate the association between use of combined oral contraceptives and risk venous thromboembolism, taking type progestogen into account. <b>Design</b> Two nested case-control studies. <b>Setting</b> General practices in United Kingdom contributing to Clinical Practice Research Datalink (CPRD; 618 practices) QResearch primary care database (722 practices). <b>Participants</b> Women aged 15-49 years with a first diagnosis thromboembolism 2001-13, each matched up five...
Abstract Objective To assess the risks of breast cancer associated with different types and durations hormone replacement therapy (HRT). Design Two nested case-control studies. Setting UK general practices contributing to QResearch or Clinical Practice Research Datalink (CPRD), linked hospital, mortality, social deprivation, registry (QResearch only) data. Participants 98 611 women aged 50-79 a primary diagnosis between 1998 2018, matched by age, practice, index date 457 498 female controls....