Tamás Szakmány
A5009577840- Sepsis Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Intensive Care Unit Cognitive Disorders
- COVID-19 Clinical Research Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Nosocomial Infections in ICU
- SARS-CoV-2 and COVID-19 Research
- Cardiac Arrest and Resuscitation
- Antibiotic Use and Resistance
- Emergency and Acute Care Studies
- Long-Term Effects of COVID-19
- Hemodynamic Monitoring and Therapy
- Pneumonia and Respiratory Infections
- COVID-19 and healthcare impacts
- Tracheal and airway disorders
- Airway Management and Intubation Techniques
- Immune Response and Inflammation
- Social Media in Health Education
- Renal function and acid-base balance
- Frailty in Older Adults
- Health Literacy and Information Accessibility
- Health Systems, Economic Evaluations, Quality of Life
- Esophageal and GI Pathology
- Trauma and Emergency Care Studies
- Central Venous Catheters and Hemodialysis
Aneurin Bevan University Health Board
2016-2025
Royal Gwent Hospital
2016-2025
Cardiff University
2016-2025
Llanfrechfa Grange Hospital
2021-2024
Royal Glamorgan Hospital
2007-2024
International Severe Acute Respiratory and Emerging Infection Consortium
2023
St Mary's Hospital
2023
Instituto de Salud Carlos III
2022
Centre for Inflammation Research
2022
University of Edinburgh
2022
There is a need to better define the epidemiology of sepsis in intensive care units (ICUs) around globe.The Intensive Care over Nations (ICON) audit prospectively collected data on all adult (>16 years) patients admitted ICU between May 8 and 18, 2012, except those for less than 24 hours routine postoperative surveillance. Data were daily maximum 28 days ICU, followed up outcome until death, hospital discharge, or 60 days. Participation was entirely voluntary.The included 10069 from Europe...
<h3>Importance</h3> In patients who require mechanical ventilation for acute hypoxemic respiratory failure, further reduction in tidal volumes, compared with conventional low volume ventilation, may improve outcomes. <h3>Objective</h3> To determine whether lower using extracorporeal carbon dioxide removal improves outcomes failure. <h3>Design, Setting, and Participants</h3> This multicenter, randomized, allocation-concealed, open-label, pragmatic clinical trial enrolled 412 adult receiving...
The goal of this task force was to examine the 1992 definition intensivist, identify gaps, and initiate a path forward define concise practical that could be applied globally. A modified Delphi technique used develop revised roles intensivist. We determined priori 75% or greater participant agreement for essential intensivist required. consisting physicians, respiratory therapist, advanced practice providers, pharmacist in critical/intensive care medicine, various settings, established with...
Abstract The early immune response to microbes is dominated by the recruitment of neutrophils whose primary function clear invading pathogens. However, there emerging evidence that play additional effector and regulatory roles. present study demonstrates human assume Ag cross-presenting functions suggests a plausible scenario for local generation APC-like through mobilization unconventional T cells in microbial metabolites. Vγ9/Vδ2 mucosal-associated invariant are abundant blood, inflamed...
To investigate respiratory and hemodynamic changes during lung recruitment descending optimal positive end-expiratory pressure (PEEP) titration.Prospective auto-control clinical trial.Adult general intensive care unit in a university hospital.Eighteen patients with acute distress syndrome.Following baseline measurements (T0), PEEP was set at 26 cm H2O performed (40/40-maneuver). Then tidal volume 4 mL/kg (T26R) lowered by 2 every mins. Optimal defined above the where Pao2 dropped > 10%....
Clear understanding of the long-term consequences critical care survivorship is essential. We investigated process and individual factors associated with mortality among ICU survivors explored hospital use in this group.Population-based data linkage study using Secure Anonymised Information Linkage databank.All ICUs between 2006 2013 Wales, United Kingdom.We identified 40,631 patients discharged alive from Welsh adult ICUs.None.Primary outcome was 365-day survival. The secondary outcomes...
Summary Demand for critical care among older patients is increasing in many countries. Assessment of frailty may inform discussions and decision making, but acute illness reliance on proxies history‐taking pose particular challenges who are critically ill. Our aim was to investigate the inter‐rater reliability Clinical Frailty Scale assessing admitted care. We conducted a prospective, multi‐centre study comparing assessments by staff from medical, nursing physiotherapy backgrounds. Each...
Introduction The emergence of the novel respiratory SARS-CoV-2 and subsequent COVID-19 pandemic have required rapid assimilation population-level data to understand control spread infection in general vulnerable populations. Rapid analyses are needed inform policy development target interventions at-risk groups prevent serious health outcomes. We aim provide an accessible research platform determine demographic, socioeconomic clinical risk factors for infection, morbidity mortality COVID-19,...
OBJECTIVES: To assess the value of machine learning approaches in development a multivariable model for early prediction ICU death patients with acute respiratory distress syndrome (ARDS). DESIGN: A development, testing, and external validation study using clinical data from four prospective, multicenter, observational cohorts. SETTING: network multidisciplinary ICUs. PATIENTS: total 1,303 moderate-to-severe ARDS managed lung-protective ventilation. INTERVENTIONS: None. MEASUREMENTS AND MAIN...
Background: In the United Kingdom, around 184,000 adults are admitted to an intensive care unit (ICU) each year with over 30% receiving mechanical ventilation. Oxygen is commonest therapeutic intervention provided these patients but it unclear how much oxygen should be administered for best clinical outcomes. Methods: The UK-ROX trial will evaluate and cost-effectiveness of conservative therapy (the minimum concentration required maintain saturation 90% ± 2%) versus usual in critically ill...
Toll-like receptor–mediated responses to pathogens can be modulated by targeting the TLR co-receptor CD14.
Summary Our aim was to prospectively determine the predictive capabilities of SEPSIS ‐1 and ‐3 definitions in emergency departments general wards. Patients with National Early Warning Score (NEWS) 3 or above suspected proven infection were enrolled over a 24‐h period 13 Welsh hospitals. The primary outcome measure mortality within 30 days. Out 5422 patients screened, 431 fulfilled inclusion criteria 380 (88%) recruited. Using definition, 212 had sepsis. When using Sequential Organ Failure...
Data on sepsis prevalence the general wards is lacking UK and in developed world. We conducted a multicentre, prospective, observational study of patients with or severe Emergency Departments (ED) Wales. During 24-hour period all NEWS≥3 were screened for presence 2 more SIRS criteria. To be eligible inclusion, had to have high clinical suspicion an infection, together systemic inflammatory response (sepsis) evidence acute organ dysfunction and/or shock (severe sepsis). There 5317 in-patients...
Introduction Early diagnosis of sepsis and discrimination from SIRS is crucial for clinicians to provide appropriate care, management treatment critically ill patients. We describe identification mRNA biomarkers peripheral blood leukocytes, able identify severe, systemic inflammation (irrespective origin) differentiate Sepsis SIRS, in adult patients within a multi-center clinical study. Methods Participants were recruited Intensive Care Units (ICUs) multiple UK hospitals, including...
The influence of perioperative blood transfusion in oral and oropharyngeal squamous cell carcinoma remains uncertain. It is believed that downregulates the immune system may have an on cancer recurrence survival. In all, 559 consecutive patients undergoing primary surgery for between 1992 2002 were included this study. Known prognostic variables along with details obtained from head neck service databases, respectively. Adjusting relevant factors Cox regression, hazard ratio having 3 or more...