A5023391663- Anesthesia and Pain Management
- Pain Management and Opioid Use
- Anesthesia and Sedative Agents
- Nausea and vomiting management
- Pediatric Pain Management Techniques
- Pain Mechanisms and Treatments
- Cardiac Arrest and Resuscitation
- Hemodynamic Monitoring and Therapy
- Nasal Surgery and Airway Studies
- Respiratory Support and Mechanisms
- Airway Management and Intubation Techniques
- Pneumocystis jirovecii pneumonia detection and treatment
- Diet and metabolism studies
- Dupuytren's Contracture and Treatments
- Cystic Fibrosis Research Advances
- Skin Diseases and Diabetes
- Enhanced Recovery After Surgery
- Inflammatory mediators and NSAID effects
- Pancreatitis Pathology and Treatment
- Pneumonia and Respiratory Infections
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Vascular Procedures and Complications
- Obstructive Sleep Apnea Research
- Inflammatory Myopathies and Dermatomyositis
- Tracheal and airway disorders
Oslo University Hospital
2008-2023
University of Oslo
2007-2021
Heidelberg University
2011
University Hospital Bonn
1970
In this study, we investigated the dose requirements, pain relief, and side effects of oxycodone versus morphine after surgery with visceral pain.Ninety-one women received IV or before end laparoscopic hysterectomy then continued patient-controlled analgesia for 24 h postoperatively.The accumulated consumption was less (13.3 +/- 10.4 mg vs 22.0 13.1 mg, P = 0.001) than morphine. With oxycodone, visual analog scale scores were significantly lower in first hour postoperatively sedation during...
Opioids may enhance pain sensitivity resulting in opioid-induced hyperalgesia (OIH). Activation of spinal cyclooxygenase play a role the development OIH. The aim this study was to demonstrate remifentanil-induced postinfusion an electrical and cold model, investigate whether COX-2 (parecoxib) or COX-1 (ketorolac) inhibition could prevent after remifentanil infusion. Sixteen healthy males were enrolled randomized, double-blind, placebo-controlled crossover study. Each subject went through 4...
Background Targiniq®, an oxycodone prolonged‐release ( PR ) formulation combined with the opioid antagonist naloxone , aims to prevent opioid‐induced constipation without impairing analgesic efficacy. This has been confirmed during prolonged use in chronic pain or cancer patients. The purpose of our study was compare clinical effects + for short‐term post‐operative management. Methods randomised, double‐blind, prospective included 85 women undergoing laparoscopic hysterectomy. two groups...
Background: Remifentanil's short‐acting analgesic effect and the potential of producing hyperalgesia is a challenge to post‐operative pain control. This study investigated whether pre‐treating patients with fentanyl before remifentanil‐based anaesthesia could reduce or consumption. Methods: One‐hundred admitted for anterior cruciate ligament repair were included in double‐blind study. Propofol remifentanil used general anaesthesia. Group Pre received 1.5 μg/kg intravenously (IV) Post placebo...
Background: COX‐2 inhibitors have been claimed to equal analgesic efficacy as non‐selective nonsteroidal anti‐inflammatory drugs, but this has disputed in animal experiments. Methods: One hundred thirty‐three women scheduled for ambulatory, laparoscopic gynaecological surgery were included randomised, double‐blind study. Group E received 120 mg etoricoxib orally premedication. K 30 ketorolac i.v. after induction of anaesthesia. General anaesthesia was induced and maintained with propofol...
Background The mortality rate in patients with severe community‐acquired pneumonia (SCAP) is high. We investigated the 5‐year and causes of death a patient population treated for SCAP our intensive care unit (ICU), compared or without chronic obstructive pulmonary disease (COPD) as comorbidity. Methods This retrospective study, which covers period 10 years, included aged > 18 years admitted to ICU primary diagnosis need mechanical ventilation more than 24 h. Data were collected from...
BACKGROUND Tapentadol is an opioid, which acts as a μ-opioid receptor agonist and inhibits noradrenaline reuptake in the central nervous system. This dual mechanism of action results synergistic analgesic effects potentially less side effects. has been shown treatment chronic pain but postoperative studies are sparse. OBJECTIVES The main aim was to compare effect tapentadol with oxycodone after laparoscopic hysterectomy. Opioid were recorded secondary outcomes. DESIGN Randomised, blinded...
A 34-year-old pregnant woman experienced cardiac arrest at home. Out-of-hospital perimortem cesarean delivery was performed 27 minutes after the collapse. Both mother and child were resuscitated had return of spontaneous circulation before they transported to a university hospital. The underwent hysterectomy developed disseminated intravascular coagulation. Despite intensive treatment, she died 8.5 hours arrival. infant extubated next day, her subsequent hospital course uneventful. She later...
Background . Long-term venous access has become the standard practice for administration of chemotherapy, fluid therapy, antibiotics, and parenteral nutrition. The most commonly used methods are percutaneous puncture subclavian internal jugular veins using Seldinger technique or surgical cutdown cephalic vein. Methods This study is based on a quality registry including all long-term central catheter insertion procedures performed in patients >18 years at our department during five-year...
Optimal management of chronic pancreatitis involves several specialties. Selection patients for surgery may benefit from evaluation by a multidisciplinary team (MDT), similar to cancer care. The aim this study was evaluate outcomes in selected after MDT decision.A prospective, observational consecutive operated pain due implementation MDT. main outcome Quality life (QoL) assessed EORTC-QLQ C30 and relief followed >3 months. Complications were registered predictive factors analyzed.Of 269...
BackgroundInhaled methoxyflurane for acute pain relief has demonstrated an analgesic effect superior to placebo. Data comparing opioid are needed. The aim of this study was determine the equi-analgesic doses inhaled vs i.v. fentanyl. Both drugs have onset within minutes and 20–30 min.MethodsTwelve subjects were included in a randomised, double-blinded, placebo-controlled crossover with four treatments: placebo (NaCl 0.9%), fentanyl 25 μg i.v., 50 or 3 ml. reported intensity using verbal...
Methoxyflurane is approved for relief of moderate to severe pain in conscious adult trauma patients: it may be self-administrated and well suited use austere environments. Trauma patients sustain injuries causing occult haemorrhage compromising haemodynamic stability, therefore important elucidate whether methoxyflurane adversely affect the response hypovolaemia.In this randomised, double-blinded, placebo-controlled, three-period crossover study, inhaled 3 ml, i.v. fentanyl 25 μg, placebo...