A5059083702- Antiplatelet Therapy and Cardiovascular Diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Venous Thromboembolism Diagnosis and Management
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Inflammatory mediators and NSAID effects
- Pharmacology and Obesity Treatment
- Sepsis Diagnosis and Treatment
- Diet and metabolism studies
- Advanced Glycation End Products research
- Platelet Disorders and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Respiratory Support and Mechanisms
- Acute Myocardial Infarction Research
- Eicosanoids and Hypertension Pharmacology
- Cardiovascular Disease and Adiposity
- COVID-19 Clinical Research Studies
- Peripheral Artery Disease Management
- Inflammatory Biomarkers in Disease Prognosis
- Cancer, Lipids, and Metabolism
- Diabetes Treatment and Management
- Kawasaki Disease and Coronary Complications
- Nosocomial Infections in ICU
- Nephrotoxicity and Medicinal Plants
- Bacterial Identification and Susceptibility Testing
- Chronic Kidney Disease and Diabetes
University of Perugia
2024
Azienda Sanitaria Unità Locale di Reggio Emilia
2015-2020
University of Chieti-Pescara
2009-2016
Nuovo Ospedale San Giovanni di Dio
2014
Azienda USL di Pescara
2009
University Foundation
2009
Foundation University
2009
Background Dickkopf‐1 ( DKK ‐1) is a major regulator of the Wnt signaling pathway, involved in inflammation, atherogenesis, and regulation glucose metabolism. Because platelets are contributors to circulating levels ‐1 other clinical settings, we aimed at characterizing platelet contribution type 2 diabetes mellitus (T2 DM ) evaluating associations with metabolism, activation, endothelial dysfunction. Methods Results A cross‐sectional comparison DKK‐1, soluble CD40L sCD 40L; reflecting...
The receptor for advanced glycation end-products (RAGE) has been implicated in obesity-related metabolic disease and accelerated atherothrombosis. We tested the hypothesis that changes endogenous secretory (es)RAGE levels as a result of excess adiposity oxidative stress may contribute to enhancing platelet activation obese women, thus increasing cardiovascular risk. Eighty otherwise healthy women 20 nonobese were studied. esRAGE plasma adiponectin reduced [median (interquartile range), 0.18...
Summary Physical activity is associated with cardiovascular risk reduction, but the effects of exercise on platelet activation remain controversial. We investigated regular high-amount, high intensity aerobic in vivo thromboxane (TX)-dependent and plasma levels platelet-derived proteins, CD40L P-selectin, whether variables changes may be related to high-density lipoprotein (HDL) extent oxidative stress stress-related inflammation, as reflected by urinary isoprostane excretion endogenous...
Background Low high‐density lipoprotein ( HDL ) levels are major predictors of cardiovascular CV events, even in patients on statin treatment with low‐density LDL at target. In animal models s protect from oxidation and blunt platelet activation. Our study aimed to examine whether related vivo oxidative stress activation, as determinants atherothrombosis. Methods Results Urinary 8‐iso‐PGF 2α 11‐dehydro‐TXB 2 , markers respectively, were measured 65 coronary heart disease (CHD)...
Platelets critically contribute to atherothrombosis and worsening ischaemia in patients with peripheral arterial disease (PAD), eventually leading critical limb (CLI). Furthermore, persistent platelet activation despite antiplatelet therapy has been reported this setting. The prostacyclin analogue iloprost is currently recommended CLI for its effects relieving symptoms by promoting local perfusion. In study, we investigated the of infusion on urinary 11-dehydro-TXB₂ 8-iso-PGF(₂α) excretion...
Circulating pentraxin 3 (PTX3), the main regulator of inflammatory response, rapidly increases following cardiovascular events, and low PTX3 is associated with high body mass index.We conducted a 12-month longitudinal study, to test hypothesis that laparoscopic adjustable gastric banding (LAGB)-induced weight loss was changes in platelet activation markers PTX3. Twelve obese patients, scheduled undergo LAGB, were enrolled at University Obesity Center. Urinary 11-dehydro-thromboxane...
An 80-year-old man was admitted because of persistent fever and dyspnea [...]
Abstract Background Adverse drug reaction (ADR) is a leading but under‐recognised cause of illness, particularly in frail subjects with multiple comorbidities. Aim To investigate the frequency, patterns and outcomes ADR as hospitalisation elderly patients admitted to an internal medicine ward. Methods We performed retrospective observational study including every patient aged over 65 years who was our department during 12‐month period. Patients short‐stay (<24 h) observation unit were...