A5075364446- Atrial Fibrillation Management and Outcomes
- Cardiovascular Function and Risk Factors
- SARS-CoV-2 and COVID-19 Research
- Autoimmune and Inflammatory Disorders Research
- Rheumatoid Arthritis Research and Therapies
- Cardiac Imaging and Diagnostics
- Systemic Lupus Erythematosus Research
- Health Systems, Economic Evaluations, Quality of Life
- Viral Infections and Immunology Research
- Drug-Induced Adverse Reactions
- Cardiac Arrhythmias and Treatments
- COVID-19 Clinical Research Studies
- Cardiomyopathy and Myosin Studies
- Cardiac pacing and defibrillation studies
- Pericarditis and Cardiac Tamponade
- Chemotherapy-induced cardiotoxicity and mitigation
- Acute Ischemic Stroke Management
- Cardiac Structural Anomalies and Repair
- Eosinophilic Disorders and Syndromes
- Inflammatory Myopathies and Dermatomyositis
- Influenza Virus Research Studies
- Cardiac tumors and thrombi
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Lipoproteins and Cardiovascular Health
- Myasthenia Gravis and Thymoma
Khoo Teck Puat Hospital
2017-2025
Blacktown & Mount Druitt Hospital
2016-2024
Western Sydney University
2018-2024
UNSW Sydney
2018-2024
The University of Sydney
2017-2023
Westmead Hospital
2011-2023
The University of Adelaide
2023
Tan Tock Seng Hospital
2010-2022
Sengkang General Hospital
2022
Center for Rheumatology
2021
ObjectivesMusculoskeletal symptoms are often unrecognised as a prominent feature of COVID-19 infection. This study hypothesised that viral arthralgia is an uncommon but distinct manifestation In addition, it aimed to characterise the other musculoskeletal presentations infection and their prognostic implications.MethodsPatients hospitalised with were divided into two groups: those without symptoms. Those subdivided according four patterns involvement: myalgia, arthralgia, backache...
Hyperammonemia syndrome (HS) from Ureaplasma infection is typically reported in posttransplant recipients, particularly lung transplant. We describe a young woman with activated PI3K delta 2 who presented HS disseminated urealyticum septic arthritis. also performed literature review of Ureaplasma-associated nontransplant patients.
Objective To describe the demographic characteristics, clinical features, functional status and quality of life elderly-onset (EORA) young-onset (YORA) rheumatoid arthritis (RA) patients in an Asian cohort. Methods We studied all RA our prospective disease registry, utilizing baseline data. EORA was defined as onset at 60 years or older. collected data from January 2001 to December 2012. Results There were 1206 cohort, which 178 (14.8%) had EORA, with a mean age 66.7 ± 5.6 years. more males...
Background Antituberculosis (anti-TB) drug allergy often involves multiple concurrently administered drugs which subsequently need to be reinitiated as no better alternatives exist. Objective To describe the results of tailored sequential desensitization-rechallenge (D-R) for anti-TB allergy. Methods Consecutive patients who had undergone D-R between 1 September 1997 and 31 January 2012 were recruited. Following resolution acute reaction, was restarted at 1:6,000 1:3 final daily dose (FDD),...
Studies of flares autoimmune inflammatory rheumatic diseases (AIIRD) after COVID-19 mRNA vaccination are limited by small sample size, short follow up or at risk selection bias.A national retrospective cohort study consecutive AIIRD patients ≥12 years old, across 8 hospitals who received least one dose a vaccine. Patients were included from the date 1st vaccine and censored time flare on clinic visit 3 months entry, whichever came first. Predictors determined Cox proportional hazards...
Abstract Objective To determine prevalence and factors associated with flares post Coronavirus disease 2019 (COVID-19) mRNA vaccination in patients rheumatoid arthritis (RA), psoriatic (PsA) spondyloarthritis (SpA). Methods A retrospective multi-centre study was conducted (January 2021 to February 2022). Data were collected during index visit, defined as first post-vaccine visit which the patient had a physician-defined flare, or if at least 3 months elapsed since vaccine dose, whichever...
All Singaporean males undergo medical screening prior to compulsory military service. A history of possible food allergy may require referral a specialist Allergy clinic ensure that special dietary needs can be taken into account during field training and deployment.To study the pattern among pre-enlistees who were referred work up suspected allergy.Retrospective all registered in Clinical Immunology/Allergy New Case Registry Clinic from 1 August 2015 31 May 2016 for allergy.One hundred...
There is increasing recognition of a clinico-serological correlation between the idiopathic inflammatory myopathies and myositis-specific autoantibodies (MSA). We review use line immunoassay-based myositis panel incorporating both MSA myositis-associated (MAA) in selected population patients.A retrospective analysis patients with assays performed 2013 were reviewed compared against clinical diagnoses.A total 96 patient samples evaluated, indications include 60 suspected (IIM), 24...
Research data are not shared.
The current gold standard for diagnosing interstitial lung disease (ILD) involves an ILD clinic evaluation, followed by discussion in a multidisciplinary meeting (MDM).However, there is paucity of data on the impact MDMs diagnosis and management ILDs Southeast Asia.We studied clinical service at university-affiliated tertiary hospital Singapore.METHODS A single-centre retrospective review was done 97 consecutive patients referred evaluation to from March 2016 August 2017. RESULTSMean age 67...
The antinuclear antibody (ANA) test is a screening for systemic autoimmune rheumatic disease (SARD). We hypothesised that the presence of anti-DFS70 in ANA-positive samples was associated with false-positive ANA and negatively SARD.A retrospective analysis patient received testing from 1 January 2016 to 30 June performed. Patient underwent via indirect immunofluorescence method using enzyme-linked immunosorbent assay.Among total 645 samples, majority (41.7%) were positive at titre 1:80....
Good syndrome (GS) is a primary immunodeficiency (PID) that presents in middle aged to older adults with features of thymoma, hypogammaglobulinemia, CD4 T lymphopenia, inverted CD4/CD8+ ratio, and impaired T-cell mitogen proliferative responses. We present patient, 62-year-old female, who first presented disease manifestation acute hepatitis from B virus (HBV) reactivation, which was subsequently complicated by recurrent hospitalizations for pneumonia concomitant Helicobacter pylori...
Abstract This is a retrospective cohort study of hospitalized adults with coronavirus disease 2019 (COVID-19). Fifty-seven patients received treatment alone, and 35 adjunctive prednisolone. A combination corticosteroids antivirals was associated lower risk clinical progression invasive mechanical ventilation or death in early COVID-19 pneumonia.
INTRODUCTION The coronavirus disease 2019 (COVID-19) pandemic is an unprecedented crisis that has affected healthcare systems worldwide. Starting as a pneumonia of unknown cause in late Wuhan, China, it quickly swept through the world and was declared by World Health Organization on 11 March 2020. Although most institutions have protocols for outbreak epidemic management, many were not prepared to handle such intensity duration. This evidenced rapid depletion shortage resources manpower,...
Abstract Background Reduction in 6-minute walk test distance (6MWD) heart failure (HF) is associated with impaired quality of life and adverse cardiovascular outcomes. Myocardial work (MW) indices are novel non-invasive measures left ventricular (LV) function which characterise myocardial contractile efficiency energy utility. Purpose We aim to assess the predictive capacity MW for functional stable non-ischaemic cardiomyopathy (NICM). Methods prospectively recruited consecutive patients...
Introduction: Subutex® is a sublingual formulation of buprenorphine that used to treat opioid dependency. It may be abused parenterally with disastrous consequences. Clinical Presentation: We present 4 cases parenteral abuse resulting in severe upper limb complications. Treatment: Two vascular complications were treated combinations anticoagulants, vasodilators, brachial plexus bock and iloprostol. One hand abscess required surgical debridement, 1 median nerve injury neurolysis. Outcome: All...