A5034068217- Respiratory Support and Mechanisms
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Intensive Care Unit Cognitive Disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Airway Management and Intubation Techniques
- Asthma and respiratory diseases
- Tracheal and airway disorders
- Cardiac Arrest and Resuscitation
- Thermal Regulation in Medicine
- COVID-19 and Mental Health
- Antifungal resistance and susceptibility
- Nosocomial Infections in ICU
- Family and Patient Care in Intensive Care Units
- Cystic Fibrosis Research Advances
- Mycobacterium research and diagnosis
- Salivary Gland Tumors Diagnosis and Treatment
- Inhalation and Respiratory Drug Delivery
- Pneumonia and Respiratory Infections
- Respiratory viral infections research
- Sepsis Diagnosis and Treatment
- Healthcare professionals’ stress and burnout
- Tuberculosis Research and Epidemiology
- Nasal Surgery and Airway Studies
Tan Tock Seng Hospital
2015-2025
Nanyang Technological University
2025
National Centre for Infectious Diseases
2021
Mount Elizabeth Hospital
2020
This study aimed to explore changes in psychological responses (perceived stress, traumatic stigma, coping) over time residents, as well their predictors. The level of perceived and coping were assessed using the Perceived Stress Scale, Impact Event-Revised, Healthcare Workers Stigma Brief Coping Orientation Problems Experienced (COPE) Inventory, respectively. We collected from 274 residents at baseline 221 3 months follow-up (timepoint 2) National Group (NHG) residency programs Singapore....
Non-tuberculous mycobacteria (NTM) infection is an increasing problem worldwide. The epidemiology of NTM in most Asian countries unknown. This study investigated the epidemiology, and clinical profile inpatients whom was isolated from various anatomical sites a Singaporean population attending major tertiary referral centre. Demographic profile, data, characteristics patients hospitalized with isolates at hospital over two-year period were prospectively assessed (2011–2012). Data collected...
Abstract Surveillance of nosocomial infections, like catheter-associated urinary tract infection (CAUTI), central line-associated bloodstream infection, possible ventilator-associated pneumonia and secondary infections were observed to study the impact COVID-19 outbreak in ICUs from Tan Tock Seng Hospital National Centre for Infectious Diseases, Singapore between February June 2020. Higher rates patients, although it was not statistically significant. Moreover, patients seem be more...
Hyperammonemia syndrome (HS) from Ureaplasma infection is typically reported in posttransplant recipients, particularly lung transplant. We describe a young woman with activated PI3K delta 2 who presented HS disseminated urealyticum septic arthritis. also performed literature review of Ureaplasma-associated nontransplant patients.
Since the outbreak of 2019 novel coronavirus (COVID-19), role physiotherapy for patients with COVID-19 infection has been highlighted by various international guidelines. Despite that, clinical information regarding rehabilitation remains limited. In this case series, we provide a insight into management in infected Singapore. The main findings are: (1) Respiratory interventions were not indicated majority series; (2) During rehabilitation, exertional or position-related desaturation is...
Abstract We aim to describe a case series of critically and non-critically ill COVID-19 patients in Singapore. This was multicentered prospective study with clinical laboratory details. Details for fifty uncomplicated ten who required mechanical ventilation were collected. compared features between the groups, assessed predictors intubation, described ventilatory management ICU patients. Ventilated significantly older, reported more dyspnea, had elevated C-reactive protein lactate...
Abstract Background An elevated blood eosinophil count when asthma is stable predicts exacerbations and therapeutic response to corticosteroids or biologics targeting eosinophils. Few studies have examined the prognostic value of eosinophils measured at exacerbation. Aim To elucidate relationship between a spot count–measured onset life‐threatening exacerbation–with indices exacerbation severity risk subsequent exacerbations. Methods Real‐world, retrospective review all cases admitted 4...
Abstract Background Proper inhaler device usage is paramount for control of underlying obstructive airway disease. Hence, education to healthcare professionals who will eventually educate patients need be done effectively. We developed an application mobile devices on six medical devices, the metered-dose (MDI), Turbuhaler, Accuhaler, Breezhaler, Ellipta and Respimat, studied if there were any difference between manufacturer’s instructions technique. The aim this study see via a phone app...
To improve the nutritional care and resource allocation of critically ill patients with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), we described their characteristics, treatment modalities clinical outcomes, compared nutrition interventions against American Society for Parenteral Enteral Nutrition (ASPEN) recommendations.This was a retrospective observational study conducted in 5 tertiary hospitals Singapore. Characteristics, modalities, outcomes SARS-CoV-2 who received...
There is paucity of data on the occurrence cardiovascular events (CVEs) in critically ill patients with sepsis. We aimed to describe incidence, risk factors and impact mortality CVEs these patients.This was a retrospective cohort study admitted medical intensive care unit (ICU) between July 2015 October 2016. The primary outcome intra-hospital CVEs, while secondary outcomes were in-hospital mortality, ICU hospital length stay.Patients sepsis (n=662) had significantly more compared those...
ABSTRACT Introduction: Acute respiratory distress syndrome (ARDS) in COVID-19 is associated with a high mortality rate, though outcomes of the different lung compliance phenotypes are unclear. We aimed to measure and examine other factors patients ARDS. Methods: Adult ARDS who required invasive mechanical ventilation at 8 hospitals Singapore were prospectively enrolled. Factors both differences between (<40mL/cm H2O) low analysed. Results: A total 102 analysed; 15 (14.7%) did not survive....
Background: Intensive care unit (ICU) stays are 2.5 times more costly than other hospital stays, and 93.3% of ICU use is for respiratory disease with ventilator support. The aim this study was to assess the role bronchoscopy on discontinuation mechanical ventilation, prompt discharge from in our institution. Methods: Retrospective review medical records patients referred bronchoscopic intervention acute failure malignant or benign central airway diseases requiring admission. Results: Twelve...
Background: COVID-19 (Coronavirus Disease 2019) is a global cause of morbidity and mortality currently. We aim to describe the acute functional outcomes critically ill coronavirus disease 2019 (COVID-19) patients after transferring out intensive care unit (ICU). Methods: 51 consecutive at national designated center for were included in this exploratory, retrospective observational cohort study from January 1 May 31, 2020. Demographic clinical data collected analyzed. Functional measured...
Prone positioning is an established treatment modality in acute respiratory distress syndrome (ARDS) and has been employed the management of ARDS severe 2019 novel coronavirus disease (COVID-19) intensive care unit (ICU) with varying clinical physiological responses. 1,2To date, Singapore seen 44,122 COVID-19 patients, majority inpatients managed at National Centre Infectious Diseases (NCID).NCID ICU 36 mechanically intubated patients thus far.We retrospectively examine first 20 NCID...
Background Delaying intubation in patients who fail high-flow nasal cannula (HFNC) may result increased mortality. The ROX index has been validated to predict HFNC failure among pneumonia with acute hypoxemic respiratory (AHRF), but little information is available for non-pneumonia causes. In this study, we validate the AHRF due both or causes, focusing on early prediction. Methods This was a retrospective observational study eight Singapore intensive care units from 1 January 2015 30...
<b>Introduction:</b> Asthma mortality in Singapore is high despite moderate asthma prevalence and having a modern, well-resourced healthcare system. <b>Aim:</b> To perform national audit of severe life-threatening (SLTA) identify gaps care. <b>Methods:</b> Review SLTA cases 4 public hospitals between 2011-2015. was defined as exacerbation requiring mechanical ventilation or intensive care unit/high dependency admission. "Adverse outcomes" (AO) death, hypoxic ischemic encephalopathy...
Lung herniation is a rare condition which has only been mainly published as case reports in the literature. Although its description around since 1845, not much still known about it. More often seen after trauma or surgical complication post thoracic surgery, it's management usually depends on etiology and varies between individuals. We report of lung positive pressure ventilation from previous thoracotomy site. To our knowledge, this first where was precipitated by mechanical ventilation.
Abstract Background Community-acquired respiratory infections are a leading cause of illness and death globally. The aetiologies community-acquired pneumonia remain poorly defined. RESPIRO study is an ongoing prospective observational cohort aimed at developing pragmatic logistical analytic platforms to accurately identify the causes moderate-to-severe in adults understand factors influencing disease caused by individual pathogens. currently underway Singapore has plans for expansion into...