A5062400435- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Eosinophilic Esophagitis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- IL-33, ST2, and ILC Pathways
- Pediatric health and respiratory diseases
- Emergency and Acute Care Studies
- Tracheal and airway disorders
- Respiratory viral infections research
- Sepsis Diagnosis and Treatment
- Pneumonia and Respiratory Infections
- Eosinophilic Disorders and Syndromes
- Chronic Disease Management Strategies
- Cystic Fibrosis Research Advances
- Neonatal Respiratory Health Research
- Allergic Rhinitis and Sensitization
- Public Health and Nutrition
- Urticaria and Related Conditions
- Atomic and Subatomic Physics Research
- Inhalation and Respiratory Drug Delivery
- Phonocardiography and Auscultation Techniques
- Global Health Care Issues
- Liver Disease Diagnosis and Treatment
- Pharmaceutical studies and practices
- COVID-19 and healthcare impacts
National University Hospital
2013-2024
National University Health System
2014-2024
National University of Singapore
2013-2024
Eastern Health
2022
Singapore Immunology Network
2022
Pulmonary Associates
2021
University of Indonesia
2021
St. Joseph’s Healthcare Hamilton
2017-2021
Tan Tock Seng Hospital
2021
Marymount University
2019
Abstract Introduction Culture-negative sepsis is a common but relatively understudied condition. The aim of this study was to compare the characteristics and outcomes culture-negative versus culture-positive severe sepsis. Methods This prospective observational cohort 1001 patients who were admitted medical intensive care unit (ICU) university hospital from 2004 2009 with Patients documented fungal, viral, parasitic infections excluded. Results There 415 (41.5%) 586 (58.5%). Gram-positive...
Inflammation and smooth muscle dysfunction are integral components of severe asthma that contribute to luminal obstruction causing airflow limitation, ventilation heterogeneity, symptoms. This is important for guiding treatment decisions directed at the inflammatory (e.g., anti-T-helper cell type 2 monoclonal antibodies) noninflammatory, muscle-mediated bronchial thermoplasty) asthma.To investigate contribution eosinophilic bronchitis magnetic resonance imaging (MRI) heterogeneity in...
The effect of employing severity scores to identify severe community-acquired pneumonia (SCAP) cases for early aggressive resuscitation is unknown. Optimising pre-intensive care unit (ICU) may improve outcomes in patients at risk SCAP. We conducted a before-and-after study classified into control and intervention groups (January 2004 December 2007 January 2008 2010, respectively). Our was two-pronged, using the Infectious Diseases Society America (IDSA)/American Thoracic (ATS) minor criteria...
Anti-interleukin (IL)-5 monoclonal antibodies as an eosinophil-depleting strategy is well established, with Mepolizumab being the first biologic approved adjunct treatment for severe eosinophilic asthma. A 62-year old woman diagnosed asthma showed poor response to therapy (100 mg subcutaneous dose/monthly) and subsequent worsening of symptoms. The was monitored using both blood sputum eosinophil counts. latter superior in assessing deterioration symptoms, suggesting that normal count may not...
Local airway autoimmune responses may contribute to steroid dependence and persistent eosinophilia in severe asthma. Auto-IgG antibodies directed against granule proteins such as eosinophil peroxidase (EPX), macrophage scavenger receptor with collagenous structure (MARCO) nuclear/extranuclear antigens (antinuclear (ANAs)) have been reported. Our objective was describe the prevalence clinical characteristics of asthmatic patients autoreactivity, assess if this could be predicted from history...
Severe asthma is a difficult-to-treat chronic airway inflammatory disease requiring systemic corticosteroids to achieve control. It has recently been shown that drugs targeting immunometabolism have elicited anti-inflammatory effects. The purpose of this study was investigate potential immunometabolic modulatory actions dexamethasone (Dex) in an Aspergillus fumigatus (Af)-induced severe model. Mice were repeatedly exposed the Af aeroallergen before treatment with Dex. Simultaneous...
Background: Pathogens are often not identified in severe community-acquired pneumonia (CAP), and the few studies using polymerase chain reaction (PCR) techniques for virus detection from temperate countries. Objective: This study assesses if PCR amplification improves bacteria detection, viral infection contributes to mortality CAP a tropical setting, where respiratory pathogens have less well-defined seasonality. Methods: In this cohort of patients with an intensive care unit, endotracheal...
The human nasal epithelium is the primary site of exposure to influenza virus, initiator host responses and resultant pathologies. Influenza virus may cause serious respiratory infection resulting in major complications, as well severe impairment airways. Here, we elucidated global transcriptomic changes during H3N2 epithelial cells from multiple individuals. Using RNA sequencing, characterized differentially-expressed genes pathways associated with occurring at following infection. We used...
Abstract Background An elevated blood eosinophil count when asthma is stable predicts exacerbations and therapeutic response to corticosteroids or biologics targeting eosinophils. Few studies have examined the prognostic value of eosinophils measured at exacerbation. Aim To elucidate relationship between a spot count–measured onset life‐threatening exacerbation–with indices exacerbation severity risk subsequent exacerbations. Methods Real‐world, retrospective review all cases admitted 4...
Patient-specific localisation of ventilation defects using hyperpolarised gas magnetic resonance imaging (MRI) introduces the possibility regionally targeted bronchial thermoplasty (BT) for treatment severe asthma. We aimed to demonstrate that BT guided by MRI reduces number radiofrequency activations while resulting in improved asthma quality-of-life and control scores are non-inferior standard BT. In a 1-year pilot randomised controlled trial, 14 patients with who were clinically eligible...
The extent of short-acting Beta-2-agonist (β2-agonist) (SABA) use across Asian countries is not well documented. As part the SABA IN Asthma (SABINA) III study, we assessed prescriptions and clinical outcomes in patients with asthma from Asia.This cross-sectional study recruited (aged ≥12 years) 8 countries. Data on disease characteristics treatments were collected using electronic case report forms. Patients classified by practice type (primary or specialist care) investigator-defined...
Management guidelines emphasise the importance of prompt therapeutic intervention for sepsis as well stroke, both which are common causes death. Unfortunately, a rate-limiting step may be delayed presentation to emergency department by patients themselves. The aim this study was assess public awareness and stroke in Singapore.This population-based, structured telephone survey adults Singapore.There were 1067 completed surveys (response rate 50.3%). population mostly comparable with actual...
Background: Aberrant epithelial remodeling and/or abnormalities in mucociliary apparatus airway epithelium contribute to infection and inflammation. It is uncertain if these changes occur both large small airways non-cystic fibrosis bronchiectasis (non-CF bronchiectasis). In this study, we aim investigate the histopathology inflammatory profile of bronchi bronchioles bronchiectasis. Methods: Excised lung tissue sections from 52 patients with non-CF were stained specific cellular markers...
Dear Sir, A 33-year-old Chinese man with no known past medical history or previous medications presented a 7-day of unrelenting fever. He worked as driver occupational exposure to rodents in the warehouse his workplace. also had prominent generalised myalgia and poor appetite. There were respiratory symptoms, altered mentation, rash, conjunctival suffusion change output colour urine. was febrile (39.4°C), normal blood pressure 123/65 mmHg, heart rate 108 beats/min saturating 96% on room air....
Objectives To evaluate asthma characteristics and treatment patterns, including short-acting β 2 -agonist (SABA) prescriptions, in primary specialist care the Singapore cohort of SABA use IN Asthma (SABINA III) study. Design Cross-sectional, observational Setting Multicentre study conducted at five sites across Singapore. Methods In patients with (aged ≥12 years), data on demographics, disease prescriptions were collected using electronic case report forms. Patients classified by...