A5021788353- HIV/AIDS Research and Interventions
- HIV, Drug Use, Sexual Risk
- HIV Research and Treatment
- Sex work and related issues
- HIV/AIDS drug development and treatment
- HIV-related health complications and treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Adolescent Sexual and Reproductive Health
- COVID-19 Clinical Research Studies
- Tuberculosis Research and Epidemiology
- COVID-19 epidemiological studies
- COVID-19 and Mental Health
- LGBTQ Health, Identity, and Policy
- Hepatitis C virus research
- SARS-CoV-2 and COVID-19 Research
- COVID-19 and healthcare impacts
- Poverty, Education, and Child Welfare
- Bacillus and Francisella bacterial research
- Infection Control and Ventilation
- Poxvirus research and outbreaks
- Syphilis Diagnosis and Treatment
- Vaccine Coverage and Hesitancy
- Parvovirus B19 Infection Studies
- Cytomegalovirus and herpesvirus research
- Mosquito-borne diseases and control
National Centre for Infectious Diseases
2018-2025
Tan Tock Seng Hospital
2016-2025
National University of Singapore
2019-2025
National University Health System
2021-2022
Nanyang Technological University
2016-2021
Abstract Understanding the particle size distribution in air and patterns of environmental contamination SARS-CoV-2 is essential for infection prevention policies. Here we screen surface samples from hospital rooms COVID-19 patients RNA. Environmental sampling conducted three airborne isolation (AIIRs) ICU 27 AIIRs general ward. 245 are collected. 56.7% have at least one contaminated. High touch shown ten (66.7%) out 15 first week illness, (20%) beyond illness ( p = 0.01, χ 2 test). Air...
BackgroundRapid identification of COVID-19 cases, which is crucial to outbreak containment efforts, challenging due the lack pathognomonic symptoms and in settings with limited capacity for specialized nucleic acid–based reverse transcription polymerase chain reaction (PCR) testing.
Key knowledge gaps remain in the understanding of viral dynamics and immune response Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection.We evaluated these characteristics established their association with clinical severity a prospective observational cohort study 100 patients PCR-confirmed SARS-CoV-2 infection (mean age, 46 years; 56% male; 38% comorbidities). samples (n = 74) were collected for culture, serum measurement IgM/IgG levels 30), plasma inflammatory cytokines...
This study aimed to explore changes in psychological responses (perceived stress, traumatic stigma, coping) over time residents, as well their predictors. The level of perceived and coping were assessed using the Perceived Stress Scale, Impact Event-Revised, Healthcare Workers Stigma Brief Coping Orientation Problems Experienced (COPE) Inventory, respectively. We collected from 274 residents at baseline 221 3 months follow-up (timepoint 2) National Group (NHG) residency programs Singapore....
Although pre-exposure prophylaxis (PrEP) has been available in Singapore since 2016, its uptake among gay, bisexual and other men-who-have-sex-with-men (GBMSM) is low. The iPARTY study was established to evaluate the acceptability feasibility of PrEP a teleconsultation service for young GBMSM aged 18 29 years. A total 53 were enrolled study. They had 5 in-person consultations teleconsultations, at 12-week intervals. Laboratory tests quarterly baseline surveys performed assess adherence,...
Sexualised substance use, or 'chemsex' has been shown to be a major factor driving the syndemic of HIV/AIDS in communities gay, bisexual, and other men who have sex with (GBMSM) around world. However, there is paucity research on chemsex among GBMSM Singapore due punitive drug laws criminalisation sexual behaviour between men. This qualitative descriptive study first explore perceptions towards, motivators engaging in, barriers addressing harms associated Singapore. We conducted 30...
Monkeypox (mpox) was declared as a global health emergency by the WHO, with most reported cases disproportionately involving gay, bisexual and other men who have sex (GBMSM). This study explored willingness of Singaporean GBMSM to receive mpox vaccines engage in changes sexual behaviour, analysed factors influencing both decisions.
Gay, bisexual and queer men in Singapore are disproportionately represented prevalent HIV infections, relative to the general population. While anticipated stigma has been found be a barrier HIV/STI testing among gay, men, little effort made contextualise such within broader sociocultural milieu. We conducted 35 in-depth interviews with purposively recruited sample of focus on topics as sexual identity development, formative experiences experience. Interviews were analysed through thematic...
Abstract Background Prolonged fever is associated with adverse outcomes in dengue viral infection. Similar patterns are observed COVID-19 unclear significance. Methods We conducted a hospital-based case–control study of patients admitted for prolonged (fever >7 days) and saddleback (recurrence fever, lasting <24 hours, after defervescence beyond day 7 illness). Fever was defined as temperature ≥38.0°C. Cytokines were determined multiplex microbead-based immunoassay subgroup...
Background Telehealth adoption for HIV care continuum accelerated during the COVID-19 pandemic. This study explored telehealth usage, motivators and barriers to adoption, implementation challenges pandemic among people living with HIV, individuals at risk community-based organisations (CBOs) in Asia. Methods cross-sectional was conducted June December 2022 using an online quantitative survey (n = 787) 744), semi-structured qualitative interviews CBOs across nine countries/territories...
Community-based participatory research (CBPR) is quickly becoming an ethical standard for research, ensuring that the processes align with values of beneficiaries and contributes to broader social justice goals. This paper reflects on a qualitative study HIV/STI risks in sex work industry Singapore aimed adopt CBPR approach. The project was conducted partnership local workers’ rights group, Project X, recruited community members be part team. data collection phase lasted approximately 6...
The performance of real-time reverse transcription polymerase chain reaction (rRT-PCR) for SARS-CoV-2 varies with sampling site(s), illness stage, and infection site.Unilateral nasopharyngeal, nasal midturbinate, throat swabs, saliva were simultaneously sampled rRT-PCR from suspected or confirmed cases COVID-19. True positives defined as patients at least 1 detected by any site on the evaluation day time point thereafter, until discharge. Diagnostic was assessed extrapolated combinations.We...
Abstract We aim to describe a case series of critically and non-critically ill COVID-19 patients in Singapore. This was multicentered prospective study with clinical laboratory details. Details for fifty uncomplicated ten who required mechanical ventilation were collected. compared features between the groups, assessed predictors intubation, described ventilatory management ICU patients. Ventilated significantly older, reported more dyspnea, had elevated C-reactive protein lactate...
Purpose International studies document that lesbian, gay, bisexual, transgender, queer and intersex (LGBTQI+) patients face significant health disparities. Studies exploring the attitudes, knowledge, preparedness comfort levels of healthcare students towards LGBTQI+ have been conducted in United States, Kingdom Malaysia. This study aims to investigate stigma for Singapore, possible upstream factors within medical education.Methods mixed-methods adopts a convergent parallel design. The Health...
Objectives Voluntary HIV testing rates are still low in several Asian countries including Singapore. self-testing (HIVST) has the potential to increase testing, leading earlier diagnosis and better prognosis. However, views of at-risk individuals, especially heterosexual men (HSM), who not coming forward for poorly understood. In this study, we examined barriers facilitators delivery preferences HIVST order implement an effective intervention Methods From May 2017 June 2018, 48 in-depth...
Co-infection of hepatitis B virus (HBV) and C (HCV) with human immunodeficiency (HIV) is associated increased risk hepatic complications mortality. A retrospective study to estimate the proportion HBV HCV co-infections in Singapore was conducted using a clinical database. We included 3065 patients who were seen under Clinical HIV Programme at largest referral centre for care between 2006 2017 tested both HCV. Factors HIV-HBV HIV-HCV determined logistic regressions. The majority (86.3%)...
We investigated the temporal trends of short-term mortality (death within 1 year diagnosis) and cause-specific deaths in human immunodeficiency virus (HIV)-infected persons by stage HIV infection at diagnosis. also assessed impact late diagnosis (LD) on mortality.Epidemiological records HIV-infected Singapore residents from National Registry were linked to death Births Deaths for observational analyses. Newly-diagnosed cases with available cluster differentiation 4 count time a 5-year period...
Objectives Gay, bisexual and other men who have sex with (GBMSM) in Singapore may fear disclosing their sexual orientation to others due negative societal attitudes, the law that criminalises relations between men, which may, turn, impede access HIV/sexually transmitted infection (STI)-related health services. This study attempts determine how selective disclosure varying social groups, extent of disclosure, serve impact HIV/STI testing patterns among GBMSM. Methods In this observational...