A5045118651- SARS-CoV-2 and COVID-19 Research
- Balance, Gait, and Falls Prevention
- COVID-19 epidemiological studies
- COVID-19 and Mental Health
- Water Governance and Infrastructure
- Cerebral Palsy and Movement Disorders
- Vaccine Coverage and Hesitancy
- Health Policy Implementation Science
- Migration, Ethnicity, and Economy
- Cold Atom Physics and Bose-Einstein Condensates
- Antibiotic Use and Resistance
- Schizophrenia research and treatment
- Socioeconomic Development in Asia
- Antibiotic Resistance in Bacteria
- Mycobacterium research and diagnosis
- Diabetic Foot Ulcer Assessment and Management
- Urban Planning and Governance
- Salivary Gland Disorders and Functions
- Mechanical and Optical Resonators
- SARS-CoV-2 detection and testing
- Geographies of human-animal interactions
- Electronic and Structural Properties of Oxides
- Islamic Finance and Banking Studies
- Topological Materials and Phenomena
- Delphi Technique in Research
Duke-NUS Medical School
2023-2025
National Centre for Infectious Diseases
2020-2025
Tan Tock Seng Hospital
2020-2024
National University of Singapore
2017-2023
Yale University
2018-2022
Singapore Eye Research Institute
2017
Singapore College of Traditional Chinese Medicine
2017
BackgroundRapid identification of COVID-19 cases, which is crucial to outbreak containment efforts, challenging due the lack pathognomonic symptoms and in settings with limited capacity for specialized nucleic acid–based reverse transcription polymerase chain reaction (PCR) testing.
Impact of the Delta variant and vaccination on SARS-CoV-2 transmission remains unclear. In Singapore, quarantine all close contacts, including entry exit PCR testing, provided opportunity to determine risk infection by compared other variants, vaccine efficacy against acquisition, symptomatic or severe COVID-19, factors associated with acquisition disease.
Assessing booster effectiveness of COVID-19 mRNA vaccine and inactivated SARS-CoV-2 over longer time intervals in response to any further variants is crucial determining optimal vaccination strategies.To determine levels protection against severe confirmed infection by types combinations boosters Singapore during the Omicron wave.This cohort study included residents aged 30 years or more vaccinated with either at least 2 doses vaccines (ie, Pfizer-BioNTech BNT162b2 Moderna mRNA-1273)...
Abstract Background Much remains unknown about the different genomic characteristics of transmission comparing Carbapenem-Resistant Enterobacterales (CREs), A. baumannii (CRAB) and P. aeruginosa (CRPA). In this study, we examine dynamics Carbapenemase-producing Organisms (CPOs) isolated in a single hospital from 2010 to 2022.Table 1.Genomic characterization CPOs detected between 2022 Methods All Carbapenemase-Producing (CPE) (n=160) identified 2015 all CRE (n=2,573), carbapenem-resistant...
Abstract Introduction Implementing falls prevention programmes in the community presents numerous challenges. We sought to understand dynamics between determinants influencing implementation develop a common conceptual model describing complexities of implementing Singapore. Methods A full-day group building workshop with series structured activities was organised 31 multidisciplinary stakeholders. Stakeholders who attended include healthcare professionals different specialities (i.e....
Abstract Infrastructure is often thought of in big material terms: dams, buildings, roads, and so on. This study, instead, draws on literatures anthropology the social sciences to analyse infrastructures relation society environment, cast current conceptions infrastructure a new light. Situating analysis context President Biden’s recent bill, paper expands what meant by included discussions infrastructure. The study examines it means for different kinds function (and whom) or not, considers...
In Singapore, quarantine of all close contacts with entry and exit polymerase chain reaction testing enabled evaluation the impact severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination pediatric age on transmission Delta variant.This retrospective cohort study included household between 1 March 2021 31 August 2021.Among 8470 variant-exposed linked to 2583 indices, full-vaccination index BNT162b2 or mRNA-1273 was associated reduction in acquisition by (adjusted odds ratio...
Ethionamide (ETH) is part of the drug arsenal available to treat multi-drug resistant tuberculosis. The current paradigm this pro-drug activation involves mycobacterial enzyme EthA and transcriptional repressor, EthR. However, several lines evidence suggest involvement additional players. ethA/R locus was deleted in Mycobacterium bovis BCG three tuberculosis (MTB) strains. While complete resistance ETH observed with KO, susceptibility dose-dependent killing were retained KO MTB mutants,...
As sustainability gains popularity in public discourse, scholars have noted its diverse uses, multiple meanings, and contradictory outcomes. This paper explores how the current proliferation of concept stems part from varied normative appeals, which turn motivate, legitimate, unsettle mobilizations. calls for an extension moral horizons beyond immediate here now, this redrawing boundaries has simultaneously produced new externalities as well enduring anxieties responses within these bounds...
<title>Abstract</title> <italic><bold>Background</bold></italic> Adults with schizophrenia experience a range of neurocognitive problems that affect their daily functioning. Evidence for the efficacy cognitive remediation in has been established, but its implementation under-resourced community-based settings is less well-studied. In recent years, interventions have also focused on strategy-learning approach favor drill-and-practice. Moreover, there an increasing recognition to address...
Due to an aging population, the rising prevalence and incidence of hip fractures associated health economic burden present a challenge healthcare systems worldwide. Studies have shown that complex interplay physiological, psychological, social factors often affects recovery trajectories older adults with fractures, complicating process.This research aims actively engage stakeholders (including doctors, physiotherapists, fracture patients, caregivers) using modeling methodology Group Model...
Falls among older adults are a significant health problem globally. Studies of multicomponent fall prevention programs in randomized controlled trials demonstrate effectiveness reducing falls; however, the translation research into community remains challenging. Although there is an increasing interest to understand factors contributing implementation barriers, dynamic relationships between less well examined. Furthermore, evidence on barriers from Asia lacking as most these studies...
The anthropology of infrastructure has emerged as a vibrant area inquiry, recent ethnographies roads, electricity networks, canals, oil pipelines, and water supply systems have provided ...
The spread of Carbapenemase-producing Organisms (CPO) remains a major threat globally. Within clinical settings, the existing method determining gene load involves traditional culture to determine bacterial and polymerase-chain-reaction-based Xpert Carba-R Assay carbapenemase type. However, there is need for fast accurate quantifying CPO colonisation study risk persistent carriage.
Falls and fall-related injuries among older adults in Singapore are a serious health problem that require early intervention. In previous research, exercise interventions have been effective improving functional outcomes reducing falls for broad group of adults. However, results from multi-domain, multi-component prevention programs high fall risk the community remain equivocal. One reason these is there significant heterogeneity factors amongst which makes tailoring multicomponent complex....