Allen C. Cheng
A5031956134- Influenza Virus Research Studies
- Antimicrobial Resistance in Staphylococcus
- Burkholderia infections and melioidosis
- Respiratory viral infections research
- Antibiotic Use and Resistance
- Bacterial Identification and Susceptibility Testing
- Pneumonia and Respiratory Infections
- Cardiac Structural Anomalies and Repair
- COVID-19 Clinical Research Studies
- Mechanical Circulatory Support Devices
- SARS-CoV-2 and COVID-19 Research
- Sepsis Diagnosis and Treatment
- Infective Endocarditis Diagnosis and Management
- Vaccine Coverage and Hesitancy
- Nosocomial Infections in ICU
- COVID-19 epidemiological studies
- Streptococcal Infections and Treatments
- Urinary Tract Infections Management
- Head and Neck Cancer Studies
- Antibiotics Pharmacokinetics and Efficacy
- Patient Satisfaction in Healthcare
- Infection Control in Healthcare
- Cardiac Valve Diseases and Treatments
- Antibiotic Resistance in Bacteria
- Clostridium difficile and Clostridium perfringens research
Alfred Health
2016-2025
Monash University
2016-2025
Monash Health
2023-2025
Legacy Emanuel Medical Center
2014-2024
Legacy Good Samaritan Medical Center
2016-2024
Providence Portland Medical Center
2014-2024
Oregon Medical Research Center
2024
New York Proton Center
2024
Monash Medical Centre
2023-2024
Lindsay Unified School District
2024
The efficacy of interleukin-6 receptor antagonists in critically ill patients with coronavirus disease 2019 (Covid-19) is unclear.We evaluated tocilizumab and sarilumab an ongoing international, multifactorial, adaptive platform trial. Adult Covid-19, within 24 hours after starting organ support the intensive care unit (ICU), were randomly assigned to receive (8 mg per kilogram body weight), (400 mg), or standard (control). primary outcome was respiratory cardiovascular support-free days, on...
Thrombosis and inflammation may contribute to morbidity mortality among patients with coronavirus disease 2019 (Covid-19). We hypothesized that therapeutic-dose anticoagulation would improve outcomes in critically ill Covid-19.
<h3>Importance</h3> Evidence regarding corticosteroid use for severe coronavirus disease 2019 (COVID-19) is limited. <h3>Objective</h3> To determine whether hydrocortisone improves outcome patients with COVID-19. <h3>Design, Setting, and Participants</h3> An ongoing adaptive platform trial testing multiple interventions within therapeutic domains, example, antiviral agents, corticosteroids, or immunoglobulin. Between March 9 June 17, 2020, 614 adult suspected confirmed COVID-19 were enrolled...
Over 20 years, from October 1989, the Darwin prospective melioidosis study has documented 540 cases tropical Australia, providing new insights into epidemiology and clinical spectrum.The principal presentation was pneumonia in 278 (51%), genitourinary infection 76 (14%), skin 68 (13%), bacteremia without evident focus 59 (11%), septic arthritis/osteomyelitis (4%) neurological 14 (3%). 298 (55%) were bacteremic 116 (21%) developed shock (58 fatal). Internal organ abscesses secondary foci...
Background: Complications of Staphylococcus aureus bacteremia (SAB) are often difficult to identify.The ability accurately predict the likelihood these complications would impact patient management.This investigation sought define readily available clinical characteristics that could help identify patients at risk for complicated SAB.Methods: A prospective, observational cohort study was conducted from September 1994 through December 1999.Patients were followed up 12 weeks after initial...
BackgroundThe Global Point Prevalence Survey (Global-PPS) established an international network of hospitals to measure antimicrobial prescribing and resistance worldwide. We aimed assess in hospital inpatients.MethodsWe used a standardised surveillance method collect detailed data about from worldwide, which were grouped by UN region. The internet-based survey included all inpatients (adults, children, neonates) receiving who on the ward at 0800 h one specific day between January September,...
Thrombosis and inflammation may contribute to the risk of death complications among patients with coronavirus disease 2019 (Covid-19). We hypothesized that therapeutic-dose anticoagulation improve outcomes in noncritically ill who are hospitalized Covid-19.In this open-label, adaptive, multiplatform, controlled trial, we randomly assigned were Covid-19 not critically (which was defined as an absence critical care-level organ support at enrollment) receive pragmatically regimens either...
These guidelines are intended for use by healthcare professionals who care children and adults with suspected or confirmed infectious diarrhea. They not to replace physician judgement regarding specific patients clinical public health situations. This document does provide detailed recommendations on infection prevention control aspects related
Abstract These guidelines are intended for use by healthcare professionals who care children and adults with suspected or confirmed infectious diarrhea. They not to replace physician judgement regarding specific patients clinical public health situations. This document does provide detailed recommendations on infection prevention control aspects related
There is broad interest in improved methods to generate robust evidence regarding best practice, especially settings where patient conditions are heterogenous and require multiple concomitant therapies. Here, we present the rationale design of a large, international trial that combines features adaptive platform trials with pragmatic point-of-care determine treatment strategies for patients admitted an intensive care unit severe community-acquired pneumonia. The uses novel design, entitled...
While Southeast Asia and northern Australia are well recognized as the major endemic regions for melioidosis, recent reports have expanded zone. Severe weather events environmental disasters such 2004 Asian tsunami unmasked locations of sporadic cases reconfirmed endemicity in Indonesia. The region now includes majority Indian subcontinent, southern China, Hong Kong Taiwan. Sporadic occurred Brazil elsewhere Americas island communities New Caledonia, Pacific Ocean, Mauritius Ocean. Some...
Abstract SARS-Cov-2 (severe acute respiratory disease coronavirus 2), which causes Coronavirus Disease 2019 (COVID19) was first detected in China late and has since then caused a global pandemic. While molecular assays to directly detect the viral genetic material are available for diagnosis of infection, we currently lack serological suitable specifically SARS-CoV-2 antibodies. Here describe enzyme-linked immunosorbent (ELISA) that developed using recombinant antigens derived from spike...
Abstract Introduction Mortality of patients on extracorporeal membrane oxygenation (ECMO) remains high. The objectives this study were to assess the factors associated with outcome undergoing ECMO in a large referral centre and compare veno-arterial (VA ECMO) veno-venous (VV ECMO). Methods We reviewed prospectively obtained database patients' medical records between January 2005 June 2011. Demographic characteristics, illness severity at admission, indication, organ failure scores before...
The coronavirus disease pandemic was declared in March 2020, as the southern hemisphere’s winter approached. Australia expected co-circulation of severe acute respiratory syndrome 2, influenza and other seasonal viruses. However, notifications were 7,029 (March–September) compared with an average 149,832 for same period 2015–2019*, despite substantial testing. Restrictions on movement within into may have temporarily eliminated influenza. Other pathogens also showed remarkably changed activity 2020.
Prosthetic joint infections remain a major complication of arthroplasty. At present, local and international guidelines recommend cefazolin as surgical antibiotic prophylaxis at the time This retrospective cohort study conducted across 10 hospitals over 3-year period (January 2006 to December 2008) investigated epidemiology microbiological etiology prosthetic infections. There were 163 cases infection identified. From review culture results, methicillin-resistant Staphylococcus aureus (MRSA)...
Fluoroquinolone antimicrobial drugs are highly bioavailable, broad-spectrum agents with activity against gram-negative pathogens, especially those resistant to other classes of drugs. Australia has restricted the use quinolones in humans through its national pharmaceutical subsidy scheme; and, regulation, not permitted food-producing animals. As a consequence, resistance fluoroquinolones community been slow emerge and remained at low levels key such as Escherichia coli. In contrast policies...
<h3>Importance</h3> Methicillin-resistant<i>Staphylococcus aureus</i>(MRSA) bacteremia is associated with mortality of more than 20%. Combining standard therapy a β-lactam antibiotic has been reduced mortality, although adequately powered randomized clinical trials this intervention have not conducted. <h3>Objective</h3> To determine whether combining an antistaphylococcal effective alone in patients MRSA bacteremia. <h3>Design, Setting, and Participants</h3> Open-label, trial conducted at...
Significance As the recall of CD8 + T cell memory promotes rapid recovery in, for example, influenza, we investigated circulating SARS-CoV-2−specific cells from COVID-19 patients. For two HLA-A*02:01 epitopes, found that, while ex vivo frequencies responding were approximately fivefold higher than pre−COVID-19 samples, they ∼10-fold lower influenza or EBV-specific cells. Additionally, recovered convalescent patients had an atypically high prevalence stem memory, central and naïve phenotypes....
Background: The Kingdom of Saudi Arabia has experienced a prolonged outbreak Middle East Respiratory Syndrome (MERS) coronavirus since 2012. Healthcare workers (HCWs) form significant risk group for infection. Objectives: aim this survey was to assess the knowledge, attitudes, infection control practices and educational needs HCWs in MERS other emerging infectious diseases. Methods: 1500 from Ministry Health were invited fill questionnaire developed cover objectives 9 September 2015 8...