A5015181811- Phagocytosis and Immune Regulation
- Immune cells in cancer
- Immune Cell Function and Interaction
- Chronic Lymphocytic Leukemia Research
- Erythrocyte Function and Pathophysiology
- Monoclonal and Polyclonal Antibodies Research
- Adenosine and Purinergic Signaling
- Cell death mechanisms and regulation
- T-cell and B-cell Immunology
- Neuroinflammation and Neurodegeneration Mechanisms
- Immunotherapy and Immune Responses
- Immunodeficiency and Autoimmune Disorders
- Health disparities and outcomes
- Viral-associated cancers and disorders
- Immune Response and Inflammation
- vaccines and immunoinformatics approaches
- Advanced MRI Techniques and Applications
- Complement system in diseases
- Functional Brain Connectivity Studies
- Statistical Methods and Bayesian Inference
- IL-33, ST2, and ILC Pathways
- COVID-19 Impact on Reproduction
- Cell Adhesion Molecules Research
- Pneumonia and Respiratory Infections
- Advanced Causal Inference Techniques
University of Virginia
2006-2024
University of Michigan
2000-2023
Carter Center
2006-2023
University of Rochester
2014-2022
Michigan United
2022
Royal Prince Alfred Hospital
2016-2021
Chris O’Brien Lifehouse
2016-2021
The University of Sydney
2016-2021
University of Rochester Medical Center
2011-2020
RELX Group (United States)
2012
The use of functional magnetic resonance imaging (fMRI) to explore central auditory function may be compromised by the intense bursts stray acoustic noise produced scanner whenever signal is read out. We present results evaluating one method reduce effect noise: "sparse" temporal sampling. Using this technique, single volumes brain images are acquired at end stimulus and baseline conditions. To optimize detection activation, taken near maxima minima hemodynamic response during experimental...
Rationale: Macrophages change their phenotype and biological functions depending on the microenvironment. In atherosclerosis, oxidative tissue damage accompanies chronic inflammation; however, macrophage phenotypic changes in response to oxidatively modified molecules are not known. Objective: To examine oxidized phospholipids that present atherosclerotic lesions. Methods Results: We show phospholipid-treated murine macrophages develop into a novel (Mox) is strikingly different from...
In longitudinal studies of developmental and disease processes, participants are followed prospectively with intermediate milestones identified as they occur. Frequently, enroll over a range ages including at which some participants’ have already passed. Ages that occur prior to study entry left censored if individuals enrolled in the or truncated not. The authors examined bias incurred by ignoring these issues when estimating distribution age time between 2 milestones. Methods account for...
The bone marrow microenvironment contributes to the regulation of hematopoietic stem cell (HSC) function, though its role in age-associated lineage skewing is poorly understood. Here we show that dysfunction aged macrophages (Mφs) directs HSC platelet bias. Mφs from mice and humans exhibited an activated phenotype, with increased expression inflammatory signals. Aged also displayed decreased phagocytic function. Senescent neutrophils, typically cleared by Mφs, were markedly mice, consistent...
Gain-of-function (GOF) mutations in PIK3CD, encoding the p110δ subunit of phosphatidylinositide 3-kinase (PI3K), cause a primary immunodeficiency. Affected individuals display impaired humoral immune responses following infection or immunization. To establish mechanisms underlying these defects, we studied large cohort patients with PIK3CD GOF and established novel mouse model using CRISPR/Cas9-mediated gene editing to introduce common pathogenic mutation Pik3cd. In both species, hyperactive...
Naive CD4+ T cells differentiate into specific effector subsets—Th1, Th2, Th17, and follicular helper (Tfh)—that provide immunity against pathogen infection. The signaling pathways involved in generating these are partially known. However, the effects of mutations underlying human primary immunodeficiencies on processes, how they compromise immune responses, remain unresolved. By studying individuals with key pathways, we identified nonredundant regulating cell differentiation vitro....
Abstract CD20 monoclonal antibodies (CD20 mAb) induce cellular cytotoxicity, which is traditionally measured by antibody-dependent cytotoxicity (ADCC) assays. However, data suggest that phagocytosis (ADCP) the primary cytotoxic mechanism. We directly compared in vitro ADCP versus ADCC using human cells. After establishing primacy of ADCP, we examined next-generation mAbs, including clinically relevant drug combinations for their effects on ADCP. and induction rituximab, ofatumumab,...
Abstract Background Neuroinflammation is thought to contribute the pathogenesis of Alzheimer’s disease (AD), yet numerous studies have demonstrated a beneficial role for neuroinflammation in amyloid plaque clearance. We previously shown that sustained expression IL-1β hippocampus APP/PS1 mice decreases burden independent recruited CCR2 + myeloid cells, suggesting resident microglia as main phagocytic effectors IL-1β-induced To date, however, mechanisms clearance remain poorly understood....
Alzheimer's disease is the leading cause of dementia worldwide. TAM receptor tyrosine kinases (Tyro3, Axl, MerTK) are known for their role in engagement phagocytosis and modulation inflammation, recent evidence suggests a complex relationship between Mer, microglial amyloid plaques AD. Gas6, primary CNS ligand, reduces neuroinflammation improves outcomes murine models disease. Therefore, we hypothesized that AAV-mediated overexpression Gas6 would alleviate plaque pathology, reduce...
Active listening has been reported to elicit a different sensory response from passive and is generally observed as an increase in the magnitude of activation.Sensory activation differences may therefore be masked by effect attention.The present study measured induced static modulated tones, while controlling attention using target-discrimination tasks.The factorial design enabled us determine whether stimulus-induced auditory cortex was independent information-processing demands...