A5042034605- Hearing Loss and Rehabilitation
- Noise Effects and Management
- Neuroscience and Music Perception
- Hearing Impairment and Communication
- Neural dynamics and brain function
- Speech and Audio Processing
- Delphi Technique in Research
- Multisensory perception and integration
- Memory and Neural Mechanisms
- Hearing, Cochlea, Tinnitus, Genetics
- Phonetics and Phonology Research
- Health Systems, Economic Evaluations, Quality of Life
- Advanced MRI Techniques and Applications
- Tactile and Sensory Interactions
- Nicotinic Acetylcholine Receptors Study
- Neural Networks and Applications
- Neural and Behavioral Psychology Studies
- Neuroendocrine regulation and behavior
- Neurotransmitter Receptor Influence on Behavior
- Functional Brain Connectivity Studies
- Visual perception and processing mechanisms
- Medical Practices and Rehabilitation
- Primate Behavior and Ecology
- Memory Processes and Influences
- Ultrasound in Clinical Applications
University of York
2010-2023
Weatherford College
2023
Hull York Medical School
2011-2018
Google (United States)
2008-2012
MRC Institute of Hearing Research
1998-2008
Queen's Medical Centre
2002-2008
University of Nottingham
1993-2006
Anna Needs Neuroblastoma Answers
2006
Medical Research Council
1995-2003
Cochlear (Australia)
2002
The use of functional magnetic resonance imaging (fMRI) to explore central auditory function may be compromised by the intense bursts stray acoustic noise produced scanner whenever signal is read out. We present results evaluating one method reduce effect noise: "sparse" temporal sampling. Using this technique, single volumes brain images are acquired at end stimulus and baseline conditions. To optimize detection activation, taken near maxima minima hemodynamic response during experimental...
<h3>Abstract</h3> <b>Objective:</b> To estimate the prevalence of confirmed permanent childhood hearing impairment and its profile across age degree in United Kingdom. <b>Design:</b> Retrospective total ascertainment through sources health education sectors by postal questionnaire. <b>Setting:</b> Hospital based otology audiology departments, community clinics, services for impaired children. <b>Participants:</b> Children born from 1980 to 1995, resident Kingdom 1998, with (hearing level...
Hierarchical processing suggests that spectrally and temporally complex stimuli will evoke more activation than do simple stimuli, particularly in non-primary auditory fields. This hypothesis was tested using two tones, a single frequency tone harmonic tone, were either static or modulated to create four stimuli. We interpret the location of differences by drawing comparisons between fMRI human cytoarchitectonic data, reported same brain space. Harmonic tones produced right Heschl's gyrus...
The objectives of this study were to identify variables that are associated with differences in outcome among hearing-impaired children and control those while assessing the impact cochlear implantation.In a cross-sectional study, parents teachers representative sample invited complete questionnaires about children's auditory performance, spoken communication skills, educational achievements, quality life. Multiple regression was used measure strength association between these outcomes...
This study reports epidemiological data for 17 160 children with permanent bilateral hearing impairment >40 dB in the UK birth cohorts 1980 95 inclusive. Children were uniquely ascertained from notifications professionals health and education. Results indicate a changing aetiological profile over cohort. The percentage of unknown aetiologies those prenatal or postnatal origin have decreased, while syndromal perinatal increased, no change genetic aetiologies. Nearly 30% hearing-impaired...
<h3>Objective</h3> Cochlear implantation in one ear (unilateral implantation) has been the standard treatment for severe-profound childhood deafness. We assessed whether cochlear both ears (bilateral is associated with better listening skills, higher health-related quality of life (health utility) and general (QOL) than unilateral implantation. <h3>Design</h3> Cross-sectional observational study. <h3>Setting</h3> University York. <h3>Participants</h3> Fifty severely-profoundly deaf 56...
Adult users of unilateral Nucleus CI24 cochlear implants with the SPEAK processing strategy were randomised either to receive a second identical implant in contralateral ear immediately, or wait 12 months while they acted as controls for late-emerging benefits first implant. Twenty four subjects, twelve from each group, completed study. Receipt led improvements self-reported abilities spatial hearing, quality and hearing speech, but generally non-significant changes measures life....
Active listening has been reported to elicit a different sensory response from passive and is generally observed as an increase in the magnitude of activation.Sensory activation differences may therefore be masked by effect attention.The present study measured induced static modulated tones, while controlling attention using target-discrimination tasks.The factorial design enabled us determine whether stimulus-induced auditory cortex was independent information-processing demands...
This paper describes systematic methods for measuring and controlling sound levels within a magnetic resonance scanner. The are illustrated by application to the acoustic noise generated 3 T scanner during echoplanar imaging (EPI). Across five measurement sessions, pressure at center of head gradient coil ranged from 122 131 dB SPL [123 132 dB(A)]. For protection against damaging exposure, UK US industrial guidelines stipulate that maximum permitted daily dosage is equivalent 90 dB(A) 8...
Abstract Listeners are able to extract important linguistic information by viewing the talker's face—a process known as “speechreading.” Previous studies of speechreading present small closed sets simple words and their results indicate that visual speech processing engages a wide network brain regions in temporal, frontal, parietal lobes likely underlie multiple stages receptive language system. The study further explored this large group subjects presenting naturally spoken sentences which...
Context: Unilateral cochlear implantation is a costeffective intervention for profound bilateral hearing loss.There worldwide interest in providing implants bilaterally.Objective: To use modeling to estimate the cost of gaining quality-adjusted life-year by both ears profoundly postlingually deafened adults.Design: Economic scenario analysis relating costs estimates gain healthrelated quality life (utility) from unilateral and implantation.Setting: Fourteen hospitals United Kingdom National...
It is a concern for auditory fMRI studies that acoustic noise generated by the scanner produces an response can confound stimulus-induced activation. To establish how to minimize this problem, present study mapped time-course of burst employing single-event method. Recorded bursts were interspersed with clustered-volume acquisitions at range stimulus-to-imaging delays map temporal resolution 1 sec. There strong responses (1.5% signal change) in primary and secondary cortex. In both cortical...
Cochlear implantation is effective at restoring partial hearing to profoundly deaf adults, but not all patients receive equal benefit. The present study evaluated the effectiveness of a computer-based self-administered training package that was designed improve speech perception among adults who had used cochlear implants for more than three years. Eleven were asked complete an hour auditory each day, five days week, period weeks. Two tasks included, one based around discriminating isolated...
The benefits of prior information about who would speak, where they be located, and when speak were measured in a multi-talker spatial-listening task. On each trial, target phrase several masker phrases allocated to 13 loudspeakers 180° arc, overlapping time slots, which started every 800 ms. Speech-reception thresholds (SRTs) as the level relative at listeners reported key words 71% correct. When phases pairs all three cues beneficial (“who” 3.2 dB, “where” 5.1 “when” 0.3 dB). Over range...
Effects of sound level on auditory cortical activation are seen in neuroimaging data. However, factors such as the response to intense ambient scanner noise and bandwidth acoustic stimuli will both confound precise quantification interpretation sound-level effects. The present study used temporally “sparse” imaging reduce effects noise. To achieve control for stimulus bandwidth, three schemes were compared matching across bandwidth: component level, root-mean-square power loudness....
In Brief Objective: To estimate the cost-effectiveness of pediatric cochlear implantation by conducting a cost-utility analysis from societal perspective. Design: cross-sectional survey, parents representative sample hearing-impaired children assessed health utility their child using revised version Health Utilities Index Mark III questionnaire. Linear regression was used to gain in associated with while controlling for eight potentially confounding variables: average (4-frequency, unaided,...
Five experiments were designed to evaluate the effectiveness of “high-variability” lexical training in improving ability normal-hearing subjects perceive noise-vocoded speech that had been spectrally shifted simulate tonotopic misalignment. Two approaches implemented. One approach required recognize isolated words, while other words sentences. Both improved identify Improvements following a single session (lasting 1–2h) auditory ranged between 7 and 12%pts significantly larger than...
Spatial hearing uses both monaural and binaural mechanisms that require sensitive for normal function. Deaf children using either bilateral (BCI) or unilateral (UCI) cochlear implants would thus be expected to have poorer spatial than normally (NH) children. However, the relationship between in these various listener groups has not previously been extensively tested under ecologically valid conditions a homogeneous group of who are UCI users. We predicted NH listeners outperform BCI would,...
Objectives were, first, to estimate the additional number of quality-adjusted life years (QALYs) gained by deaf children from bilateral compared with unilateral implantation (DeltaQ); second, cost healthcare system in United Kingdom for providing (DeltaC); and, third, compare values incremental net benefit (INB), rDeltaQ - DeltaC, criteria used policy makers deciding whether adopt health technologies. In England and Wales, policy-making body must be satisfied that INB is positive a maximum...
In Brief Objectives: Policy-makers have struggled to define the minimum degree of hearing impairment at which children should be offered cochlear implants rather than less invasive alternative acoustic aids. This study compared outcomes for with bilateral and aids, determine a criterion candidacy pediatric implantation. Design: observational measured listening skills who received routine audiological care in United Kingdom. Participants were recruited from hospitals, educational services,...