A5010068086- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Monoclonal and Polyclonal Antibodies Research
- Immunotherapy and Immune Responses
- Immunodeficiency and Autoimmune Disorders
- Animal Ecology and Behavior Studies
- Hepatitis C virus research
- Hematopoietic Stem Cell Transplantation
- CAR-T cell therapy research
- Species Distribution and Climate Change
- Acute Lymphoblastic Leukemia research
- Viral Infections and Immunology Research
- Chronic Lymphocytic Leukemia Research
- SARS-CoV-2 and COVID-19 Research
- Avian ecology and behavior
Garvan Institute of Medical Research
2017-2025
UNSW Sydney
2020-2025
St Vincent's Clinic
2020-2025
Environmental Earth Sciences
2022
Australian National University
2016
Abstract Vaccine-induced immunity depends on the generation of memory B cells (MBC). However, where and how MBCs are reactivated to make neutralising antibodies remain unknown. Here we show that prepositioned in a subcapsular niche lymph nodes where, upon reactivation by antigen, they rapidly proliferate differentiate into antibody-secreting plasma proliferative foci (SPF). This novel structure is enriched for signals provided T follicular helper antigen-presenting sinus macrophages....
The unexplained association between infection and autoimmune disease is strongest for hepatitis C virus-induced cryoglobulinemic vasculitis (HCV-cryovas). To analyze its origins, we traced the evolution of pathogenic rheumatoid factor (RF) autoantibodies in four HCV-cryovas patients by deep single-cell multi-omic analysis, revealing three sources B cell somatic mutation converged to drive accumulation a large disease-causing clone. A method quantifying low-affinity binding revealed recurring...
Abstract Self-tolerance by clonal anergy of B cells is marked an increase in IgD and decrease IgM antigen receptor surface expression, yet the function on anergic obscure. Here we define RNA landscape vivo response, comprising 220 induced sequences including a core set 97. Failure to co-express with decreases overall expression receptors for self-antigen, but paradoxically increases exemplified increased Sdc1 encoding cell marker syndecan-1. expressed its own nevertheless competent induce...
The unexplained association between infection and autoimmune disease is strongest for hepatitis C virus-induced cryoglobulinemic vasculitis (HCV-CV). We traced the evolution of pathogenic rheumatoid factor (RhF) autoantibodies in four HCV-CV patients by deep single cell multi-omic analysis, revealing three sources B somatic mutation converged to drive accumulation a large causing clone. A sensitive method quantifying low affinity binding revealed recurring heavy/light chain combinations...
Abstract PAX5 is the master transcription factor controlling B cell identity. In humans, mutations in account for 30% of acute lymphoblastic leukemia (B-ALL) cases. Investigating causal effects has however been difficult due to premature lethality Pax5 −/− mice. Here we describe a novel mouse strain with STOP mutation (Y351*) that produces truncated protein and reduction function, yet still allows some development occur. A population uncommitted multipotent CD19 + B220 − cells develops bone...
ABSTRACT Live trapping is a common survey technique used to sample small terrestrial mammal populations, but too often traps are disturbed by non-target species, especially birds such as corvids, resulting in considerable waste of time and effort. This study aimed test whether visual cues associated with increased the disturbance rate birds, which renowned for their attraction stimuli. We manipulated trap covering (plastic bag, hessian uncovered traps) conjunction presence absence flagging...