A5015179336- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- HIV Research and Treatment
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- COVID-19 epidemiological studies
- Immunotherapy and Immune Responses
- SARS-CoV-2 detection and testing
- Long-Term Effects of COVID-19
- Immune responses and vaccinations
- Monoclonal and Polyclonal Antibodies Research
- vaccines and immunoinformatics approaches
- HIV/AIDS drug development and treatment
- Influenza Virus Research Studies
- Cytomegalovirus and herpesvirus research
- Herpesvirus Infections and Treatments
- Vaccine Coverage and Hesitancy
- RNA Interference and Gene Delivery
- Reproductive System and Pregnancy
- Viral gastroenteritis research and epidemiology
- Immune Response and Inflammation
- Pregnancy and Medication Impact
- HIV/AIDS Research and Interventions
- Viral-associated cancers and disorders
- Viral Infections and Immunology Research
UNSW Sydney
2016-2025
The George Institute for Global Health
2024
Pelita Harapan University
2012
Immune memory after vaccination Vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has proven highly effective at preventing COVID-19. However, the evolution of viral variants, and waning antibody levels over time, raise questions regarding longevity vaccine-induced immune protection. Goel et al . examined B T lymphocyte responses in individuals who received SARS-CoV-2 messenger RNA vaccines. They performed a 6-month longitudinal study never had infection...
The durability of infection-induced SARS-CoV-2 immunity has major implications for reinfection and vaccine development. Here, we show a comprehensive profile antibody, B cell T dynamics over time in cohort patients who have recovered from mild-moderate COVID-19. Binding neutralising antibody responses, together with individual serum clonotypes, decay the first 4 months post-infection. A similar decline Spike-specific CD4+ circulating follicular helper frequencies occurs. By contrast,...
Human infection challenge permits in-depth, early, and pre-symptomatic characterization of the immune response, enabling identification factors that are important for viral clearance. Here, we performed intranasal inoculation 34 young adult, seronegative volunteers with a pre-Alpha severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strain. Of these participants, 18 (53%) became infected showed an interferon-dominated mediator response divergent kinetics between nasal systemic...
In HIV-1-infected patients, increased numbers of circulating CD8+ T cells are linked to risk morbidity and mortality. Here, we identified a bystander mechanism that promotes CD8 cell activation expansion in untreated patients. Compared with healthy controls, patients have an population proliferating, granzyme B+, circulation. Vβ expression deep sequencing CDR3 revealed HIV-1 infection, cycling memory possess broad repertoire reflects the resting population. This suggests is driven by...
HIV and SIV infection dynamics are commonly investigated by measuring plasma viral loads. However, this total load value represents the sum of many individual events, which difficult to independently track using conventional sequencing approaches. To overcome challenge, we generated a genetically tagged virus stock (SIVmac239M) with 34-base genetic barcode inserted between vpx vpr accessory genes infectious molecular clone SIVmac239. Next-generation identified at least 9,336 barcodes, or...
When nanoparticles interact with human blood, a multitude of plasma components adsorb onto the surface nanoparticles, forming biomolecular corona. Corona composition is known to be influenced by chemical nanoparticles. In contrast, possible effects variations in blood proteome between healthy individuals on formation corona and its subsequent interactions immune cells are unknown. Herein, we prepared examined matrix 11 particles (including organic inorganic three sizes five chemistries)...
ABSTRACT SARS-CoV-2 mRNA vaccines have shown remarkable efficacy, especially in preventing severe illness and hospitalization. However, the emergence of several variants concern reports declining antibody levels raised uncertainty about durability immune memory following vaccination. In this study, we longitudinally profiled both cellular responses naïve recovered individuals from pre-vaccine baseline to 6 months post-mRNA Antibody neutralizing titers decayed peak but remained detectable all...
In this paper, finite element based neural network is developed. The purpose to solve differential equation and inverse problem of equation. Inverse a for parameters equation, assuming that the solution already known beforehand. mainly used approximate physical material. Finite method will be combined with artificial using back propagation algorithm Levenberg-Marquardt training problem. By proposed method, matrix calculation not needed solving both From any given solved first. And validate...
A considerable body of evidence suggests that Fc-dependent functions improve the capacity broadly neutralizing antibodies (BnAbs) to protect against and control HIV-1 infection. This phenomenon, however, has not been formally tested in robust cell-associated macaque simian-human immunodeficiency virus (SHIV) models with newer-generation BnAbs. We studied both WT BnAb PGT121 a LALA mutant (which impaired functions) for their ability pigtail macaques from an i.v. high-dose SHIVSF162P3...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) breakthrough infection of vaccinated individuals is increasingly common with the circulation highly immune evasive and transmissible Omicron variants. Here, we report dynamics durability recalled spike-specific humoral immunity following BA.1 or BA.2 infection, longitudinal sampling up to 8 months after infection. Both infections robustly boosted neutralization activity against infecting strain while expanding breadth BA.4,...
Lipid nanoparticle mRNA vaccines are an exciting but emerging technology used in humans. There is limited understanding of the factors that influence their biodistribution and immunogenicity. Antibodies to poly(ethylene glycol) (PEG), which on surface lipid nanoparticle, detectable humans boosted by human vaccination. We hypothesized PEG-specific antibodies could increase clearance vaccines. To test this, we developed methods quantify both vaccine ionizable frequent serial blood samples from...
Abstract Both previous infection and vaccination have been shown to provide potent protection from COVID-19. However, there are concerns that waning immunity viral variation may lead a loss of over time. Predictive models immune urgently needed identify correlates assist in the future deployment vaccines. To address this, we modelled relationship between vitro neutralisation levels observed SARS-CoV-2 using data seven current vaccines as well convalescent cohorts. Here show level is highly...