A5087347737- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- vaccines and immunoinformatics approaches
- Monoclonal and Polyclonal Antibodies Research
- Peptidase Inhibition and Analysis
- Advanced Proteomics Techniques and Applications
- Drug-Induced Adverse Reactions
- Cytomegalovirus and herpesvirus research
- Diabetes and associated disorders
- CAR-T cell therapy research
- Protein Degradation and Inhibitors
- Influenza Virus Research Studies
- Nicotinic Acetylcholine Receptors Study
- Mass Spectrometry Techniques and Applications
- Biotin and Related Studies
- Chemical Synthesis and Analysis
- Analytical Chemistry and Chromatography
- HIV Research and Treatment
- Urticaria and Related Conditions
- Receptor Mechanisms and Signaling
- Pancreatic function and diabetes
- Cancer Immunotherapy and Biomarkers
- Virus-based gene therapy research
- Glycosylation and Glycoproteins Research
Monash University
2016-2025
Australian Regenerative Medicine Institute
2016-2025
Discovery Institute
2016-2025
The University of Melbourne
2008-2024
Peter Doherty Institute
2024
Guy's and St Thomas' NHS Foundation Trust
2024
Institute of Infection and Immunity
2024
University of Oxford
2020
Jenner Institute
2020
Biotechnology Institute
2005-2012
Susceptibility to a clinically significant drug hypersensitivity syndrome associated with abacavir use seems have strong genetic component. We previously shown that the presence of HLA-B * 5701 strongly predicts and identified potential susceptibility locus within 300-kb region between MEGT1 C4A6 loci in central MHC. now report results fine recombinant mapping an expanded patient population 248 consecutive, fully ascertained, abacavir-exposed individuals Western Australian HIV Cohort Study,...
Rheumatoid arthritis (RA) is strongly associated with the human leukocyte antigen (HLA)-DRB1 locus that possesses shared susceptibility epitope (SE) and citrullination of self-antigens. We show how citrullinated aggrecan vimentin epitopes bind to HLA-DRB1*04:01/04. Citrulline was accommodated within electropositive P4 pocket HLA-DRB1*04:01/04, whereas electronegative RA-resistant HLA-DRB1*04:02 allomorph interacted arginine or citrulline-containing epitopes. Peptide elution studies revealed...
In animals, immunomodulatory dendritic cells (DCs) exposed to autoantigen can suppress experimental arthritis in an antigen-specific manner. rheumatoid (RA), disease-specific anti-citrullinated peptide autoantibodies (ACPA or anti-CCP) are found the serum of about 70% RA patients and strongly associated with HLA-DRB1 risk alleles. This study aimed explore safety biological clinical effects autologous DCs modified a nuclear factor κB (NF-κB) inhibitor four citrullinated antigens, designated...
Abstract The role of microglia cells in Alzheimer’s disease (AD) is well recognized, however their molecular and functional diversity remain unclear. Here, we isolated amyloid plaque-containing (using labelling with methoxy-XO4, XO4 + ) non-containing (XO4 − from an AD mouse model. Transcriptomics analysis identified different transcriptional trajectories ageing mice. microglial transcriptomes demonstrated dysregulated expression genes associated late onset AD. We further showed that the...
More than 100 species of venomous cone snails (genus Conus) are highly effective predators fish. The vast majority venom components identified and functionally characterized to date neurotoxins specifically targeted receptors, ion channels, transporters in the nervous system prey, predators, or competitors. Here we describe a component targeting energy metabolism, radically different mechanism. Two fish-hunting snails, Conus geographus tulipa, have evolved specialized insulins that expressed...
The autoimmune process that destroys the insulin-producing pancreatic beta cells in type 1 diabetes (T1D) is targeted at insulin and its precursor, proinsulin. T recognize proximal A-chain of human were identified recently lymph nodes subjects who had T1D. To investigate specificity proinsulin-specific T1D, we isolated CD4(+) cell clones to proinsulin from blood a donor recognized naturally processed, HLA DR4-restricted epitope within first 13 amino acids (A1-13) insulin. recognition was...
Type 1 diabetes (T1D) is characterized by immune responses against several autoantigens expressed in pancreatic β cells. T cells specific for proinsulin and islet-specific glucose-6-phosphatase catalytic subunit–related protein (IGRP) can induce T1D NOD mice. However, whether to multiple are caused spreading from one another or they develop independently of each other unknown. As cytotoxic IGRP were not detected transgenic mice tolerant proinsulin, we determined that necessary IGRP-specific...
HLA-B*4402 and B*4403 are naturally occurring MHC class I alleles that both found at a high frequency in all human populations, yet they only differ by one residue on the alpha2 helix (B*4402 Asp156-->B*4403 Leu156). CTLs discriminate between B*4403, these allotypes stimulate strong mutual allogeneic responses reflecting their known barrier to hemopoeitic stem cell transplantation. Although share >95% of peptide repertoire, presents more unique peptides than B*4402, consistent with stronger...