A5033818609- Blood Pressure and Hypertension Studies
- Health Systems, Economic Evaluations, Quality of Life
- Primary Care and Health Outcomes
- Health disparities and outcomes
- Chronic Disease Management Strategies
- Influenza Virus Research Studies
- Sleep and related disorders
- Respiratory viral infections research
- Cardiac Health and Mental Health
- Obstructive Sleep Apnea Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Mobile Health and mHealth Applications
- Health Promotion and Cardiovascular Prevention
- Obesity and Health Practices
- Frailty in Older Adults
- Health Literacy and Information Accessibility
- Data-Driven Disease Surveillance
- Dementia and Cognitive Impairment Research
- Lipoproteins and Cardiovascular Health
- Vaccine Coverage and Hesitancy
- Obesity, Physical Activity, Diet
- Eating Disorders and Behaviors
- Clinical practice guidelines implementation
- Musculoskeletal pain and rehabilitation
- Pharmaceutical Practices and Patient Outcomes
The University of Adelaide
2016-2025
Adelaide Institute for Sleep Health
2020-2024
National Health and Medical Research Council
2016-2024
Flinders University
2020-2024
SleepMed
2024
SA Health
2023-2024
Health Net
2023-2024
Princess Alexandra Hospital
2024
The University of Queensland
2024
IS practice
2023
Aspirin is a well-established therapy for the secondary prevention of cardiovascular events. However, its role in primary disease unclear, especially older persons, who have an increased risk.
In the primary analysis of Aspirin in Reducing Events Elderly (ASPREE) trial, now published Journal, we report that daily use aspirin did not provide a benefit with regard to end point disability-free survival among older adults. A numerically higher rate secondary death from any cause was observed than placebo.
Information on the use of aspirin to increase healthy independent life span in older persons is limited. Whether 5 years daily low-dose therapy would extend disability-free seniors unclear.From 2010 through 2014, we enrolled community-dwelling Australia and United States who were 70 age or (or ≥65 among blacks Hispanics States) did not have cardiovascular disease, dementia, physical disability. Participants randomly assigned receive 100 mg per day enteric-coated placebo orally. The primary...
Abstract Background Little is known about the epidemiology and health related quality of life (HRQoL) new DSM-5 diagnoses, Binge Eating Disorder (BED) Avoidant/Restrictive Food Intake (ARFID) in Australian population. We aimed to investigate prevalance burden these disorders. Methods conducted two sequential population-based surveys including individuals aged over 15 years who were interviewed 2014 ( n = 2732) 2015 =3005). Demographic information diagnostic features eating disorders asked...
The coronavirus disease pandemic was declared in March 2020, as the southern hemisphere’s winter approached. Australia expected co-circulation of severe acute respiratory syndrome 2, influenza and other seasonal viruses. However, notifications were 7,029 (March–September) compared with an average 149,832 for same period 2015–2019*, despite substantial testing. Restrictions on movement within into may have temporarily eliminated influenza. Other pathogens also showed remarkably changed activity 2020.
There are no primary prevention trials of aspirin with relevant geriatric outcomes in elderly people. ASPirin Reducing Events the Elderly (ASPREE) is a placebo-controlled trial low-dose that will determine whether 5 years daily 100-mg enteric-coated extends disability-free and dementia-free life healthy population these benefits outweigh risks. Set care, this randomized double-blind has composite endpoint death, incident dementia or persistent physical disability. Participants aged 70+...
Hypertension affects about 30% of adults worldwide. Garlic has blood pressure-lowering properties and the mechanism action is biologically plausible. Our trial assessed effect, dose–response, tolerability acceptability different doses aged garlic extract as an adjunct treatment to existing antihypertensive medication in patients with uncontrolled hypertension. A total 79 general practice systolic hypertension participated a double-blind randomised placebo-controlled dose–response 12 weeks....
Background Thoughts about death and self-harm in old age have been commonly associated with the presence of depression, but other risk factors may also be important. Aims To determine independent association between suicidal ideation later life demographic, lifestyle, socioeconomic, psychiatric medical factors. Method A cross-sectional study was conducted a community-derived sample 21290 adults aged 60-101 years enrolled from Australian primary care practices. We considered that participants...
In Brief Objective: The aim of this pilot study was to assess any trends related the timing initiation, and duration, hormone therapy (HT) use on cognitive function facilitate design power calculations for a future large cohort entitled Research into Memory, Brain Estrogen Replacement (REMEMBER). Design: A total 428 women aged older than 60 years were recruited from computer-generated random selection Adelaide households. Demographic lifestyle characteristics, HT history recorded confirmed....
This study aimed to determine: (1) the prevalence of depression, anxiety, and depression associated with anxiety (DA); (2) risk factor profile DA; (3) course DA over 24 months.Two-year longitudinal 20,036 adults aged 60+ years. We used Patient Health Questionnaire Hospital Anxiety Depression Scale subscale establish presence standard procedures collect demographic, lifestyle, psychosocial, clinical data.The was 4.7%, 1.4%, 1.8%. About 57% cases showed evidence comorbid while only 28% those...
Data resource basics MedicineInsight programmeMedicineInsight is a large-scale primary care database of longitudinal de-identified electronic health records (EHRs) in Australia.The programme collates routinely collected EHR data from clinical information systems (CISs) consenting general practices which have agreed to provide on an ongoing basis.MedicineInsight was established by NPS MedicineWise 2011, with core funding the Australian Government Department Health, support quality improvement...
In 2017, influenza seasonal activity was high in the southern hemisphere. We present interim vaccine effectiveness (VE) estimates from Australia. Adjusted VE low overall at 33% (95% confidence interval (CI): 17 to 46), 50% CI: 8 74) for A(H1)pdm09, 10% -16 31) A(H3) and 57% 41 69) B. For A(H3), poorer those vaccinated current prior seasons.
Background Appropriate understanding of health information by patients with cardiovascular disease (CVD) is fundamental for better management risk factors and improved morbidity, which can also benefit their quality life. Objectives To assess the relationship between literacy health-related life (HRQoL) in ischaemic heart (IHD), to investigate role sociodemographic clinical variables as possible confounders. Methods Cross-sectional study IHD recruited from a stratified sample general...
Abstract Background Poor social health is associated with increased risk of cardiovascular disease (CVD). Recent research suggests that different domains should be considered separately as the implications for and possible interventions may differ. Aim To assess isolation, low support loneliness predictors CVD. Methods Secondary analysis 11,486 community-dwelling, Australians, aged 70 years over, free CVD, dementia, or significant physical disability, from ASPirin in Reducing Events Elderly...
Objectives: To assess whether social isolation, support, and loneliness are independently associated with health-related quality of life (HRQoL).Method: Retrospective analysis including 10,517 women aged 70-75 years from the Australian Longitudinal Study on Women's Health (ALSWH). Social support (Duke Support Index), (single item) were investigated for their association standardised HRQoL (physical [PCS] mental [MCS] components SF-36® questionnaire). Analyses adjusted sociodemographic...
Abstract Introduction The 2023 Australian guideline for assessing and managing cardiovascular disease risk provides updated evidence‐based recommendations the clinical assessment management of (CVD) primary prevention. It includes new CVD calculator (Aus Risk Calculator), based on an equation developed from a large New Zealand cohort study, customised recalibrated population. replaces 2012 that recommended using Framingham equation. Main recommends in people without known CVD: all aged 45–79...