A5054368962- Frailty in Older Adults
- Dementia and Cognitive Impairment Research
- Health Systems, Economic Evaluations, Quality of Life
- Blood Pressure and Hypertension Studies
- Antiplatelet Therapy and Cardiovascular Diseases
- Nutrition and Health in Aging
- Lipoproteins and Cardiovascular Health
- Health disparities and outcomes
- Heart Rate Variability and Autonomic Control
- Heart Failure Treatment and Management
- Inflammatory mediators and NSAID effects
- Cardiac Health and Mental Health
- Nutritional Studies and Diet
- Genetic Associations and Epidemiology
- Pharmaceutical Practices and Patient Outcomes
- Epigenetics and DNA Methylation
- Neuroendocrine regulation and behavior
- Chronic Disease Management Strategies
- Electrolyte and hormonal disorders
- Health, Environment, Cognitive Aging
- Eicosanoids and Hypertension Pharmacology
- Liver Disease Diagnosis and Treatment
- Hormonal Regulation and Hypertension
- Diet and metabolism studies
- Stress Responses and Cortisol
Monash University
2016-2025
Harvard University
2024
University of Iowa
2020-2024
University of Tasmania
2020-2024
Massachusetts General Hospital
2024
Alfred Health
1988-2023
Hennepin Healthcare Research Institute
2020-2023
Berman Center for Outcomes and Clinical Research
2020-2023
Curtin University
2020-2023
Rush University Medical Center
2020-2023
Aspirin is a well-established therapy for the secondary prevention of cardiovascular events. However, its role in primary disease unclear, especially older persons, who have an increased risk.
In the primary analysis of Aspirin in Reducing Events Elderly (ASPREE) trial, now published Journal, we report that daily use aspirin did not provide a benefit with regard to end point disability-free survival among older adults. A numerically higher rate secondary death from any cause was observed than placebo.
Information on the use of aspirin to increase healthy independent life span in older persons is limited. Whether 5 years daily low-dose therapy would extend disability-free seniors unclear.From 2010 through 2014, we enrolled community-dwelling Australia and United States who were 70 age or (or ≥65 among blacks Hispanics States) did not have cardiovascular disease, dementia, physical disability. Participants randomly assigned receive 100 mg per day enteric-coated placebo orally. The primary...
There are no primary prevention trials of aspirin with relevant geriatric outcomes in elderly people. ASPirin Reducing Events the Elderly (ASPREE) is a placebo-controlled trial low-dose that will determine whether 5 years daily 100-mg enteric-coated extends disability-free and dementia-free life healthy population these benefits outweigh risks. Set care, this randomized double-blind has composite endpoint death, incident dementia or persistent physical disability. Participants aged 70+...
To determine the effect of low-dose aspirin vs placebo on incident all-cause dementia, Alzheimer disease (AD), mild cognitive impairment (MCI), and decline in older individuals.
<h3>Importance</h3> Dual decline in gait speed and cognition has been found to be associated with increased dementia risk previous studies. However, it is unclear if risks are conferred by a domain-specific gait. <h3>Objective</h3> To examine associations between dual (ie, global, memory, processing speed, verbal fluency) of dementia. <h3>Design, Setting, Participants</h3> This cohort study used data from older adults Australia the US who participated randomized clinical trial testing...
Abstract Background ASPirin in Reducing Events the Elderly, a randomized, double-blind, placebo-controlled trial of daily low-dose aspirin (100 mg) older adults, showed an increase all-cause mortality, primarily due to cancer. In contrast, prior randomized controlled trials, mainly involving younger individuals, demonstrated delayed cancer benefit with aspirin. We now report detailed analysis incidence and mortality. Methods 19 114 Australian US community-dwelling participants aged 70 years...
Objective There is a lack of robust data on significant gastrointestinal bleeding in older people using aspirin. We calculated the incidence, risk factors and absolute from large randomised, controlled trial. Design Data were extracted an aspirin versus placebo primary prevention trial conducted throughout 2010–2017 (‘ASPirin Reducing Events Elderly (ASPREE)’, n=19 114) community-dwelling persons aged ≥70 years. Clinical characteristics collected at baseline annually. The endpoint was major...
Abstract Background Poor social health is associated with increased risk of cardiovascular disease (CVD). Recent research suggests that different domains should be considered separately as the implications for and possible interventions may differ. Aim To assess isolation, low support loneliness predictors CVD. Methods Secondary analysis 11,486 community-dwelling, Australians, aged 70 years over, free CVD, dementia, or significant physical disability, from ASPirin in Reducing Events Elderly...
Objective This study was conducted to estimate prevalence rates and factors associated with depressive symptoms indexed by the Centre for Epidemiological Studies‐Depression (CES‐D‐10) score in a large sample of community‐dwelling healthy older adults from Australia United States. Convergent divergent validity CES‐D‐10 were also examined. Methods A total 19 114 individuals aged greater than or equal 65 years old enrolled primary prevention clinical trial. Depressive classified using 8 10....
OBJECTIVES To investigate the association between depressive symptoms and several medical morbidities, their combination, in a large older population. DESIGN Cross‐sectional study of baseline data from ASPirin Reducing Events Elderly (ASPREE) trial. SETTING Multicentric conducted Australia United States. PARTICIPANTS A total 19,110 adults (mean age = 75 years [standard deviation ±4.5]). MEASUREMENTS Depressive were measured using Center for Epidemiological Studies Depression (CES‐D 10)...
Poor social health is prevalent in older adults and may be associated with worse cognition, increased dementia risk. The aim of this study was to determine whether isolation, support loneliness are independently cognitive function incident over 5 years adults, investigate potential gender differences.
Importance The association between weight change and subsequent cause-specific mortality among older adults is not well described. significance of changes in waist circumference (WC) has also been compared with for this purpose. Objective To examine the associations body WC all-cause mortality. Design, Setting, Participants This cohort study a post hoc analysis data from Aspirin Reducing Events Elderly (ASPREE) randomized clinical trial, which recruited participants March 1, 2010, December...
Abstract Females live longer than males, and there are sex disparities in physical health disease incidence. However, differences biological aging have not been consistently reported may differ depending on the measure used. This study aimed to determine correlations between epigenetic age acceleration (AA), other markers of aging, separately males females. We additionally explored extent which these AA measures differed according socioeconomic characteristics, clinical markers, diseases....
Importance Low-dose aspirin has been widely used for primary and secondary prevention of stroke. The balance between potential reduction ischemic stroke events increased intracranial bleeding not established in older individuals. Objective To establish the risks among healthy people receiving daily low-dose aspirin. Design, Setting, Participants This analysis Aspirin Reducing Events Elderly (ASPREE) randomized, double-blind, placebo-controlled trial was conducted community-dwelling living...
Egg consumption in adults has been linked with a modestly increased risk of all-cause and CVD mortality. However, evidence on aged 65 y+ is limited. The objective this study was to investigate the association between egg intake mortality community-dwelling older adults. In prospective cohort study, 8756 70+ years, participants ASPirin Reducing Events Elderly (ASPREE) Longitudinal Study Older Persons, self-reported frequency their total intake: never/infrequently (rarely/never, 1-2...
Lipid metabolism in older adults is affected by various factors including biological aging, functional decline, reduced physiologic reserve, and nutrient intake. The dysregulation of lipid could adversely affect brain health. This study investigated the association between year-to-year intraindividual variability subsequent risk cognitive decline dementia community-dwelling adults. ASPirin Reducing Events Elderly (ASPREE) was a randomized trial aspirin, involving 19,114 participants aged 65...