A5042151762- Tryptophan and brain disorders
- Diet and metabolism studies
- Nutritional Studies and Diet
- Bipolar Disorder and Treatment
- Bone health and osteoporosis research
- Nutrition and Health in Aging
- Health disparities and outcomes
- Stress Responses and Cortisol
- Hip and Femur Fractures
- Health Systems, Economic Evaluations, Quality of Life
- Consumer Attitudes and Food Labeling
- Sensory Analysis and Statistical Methods
- Obesity, Physical Activity, Diet
- Frailty in Older Adults
- Mental Health Research Topics
- Cardiac Health and Mental Health
- Gut microbiota and health
- Dementia and Cognitive Impairment Research
- Colorectal Cancer Screening and Detection
- Treatment of Major Depression
- Cancer survivorship and care
- Eating Disorders and Behaviors
- Diabetes Management and Education
- Digital Mental Health Interventions
- Mobile Health and mHealth Applications
Barwon Health
2016-2025
Deakin University
2016-2025
Black Dog Institute
2016-2022
University of Eastern Finland
2022
Kuopio University Hospital
2022
Murdoch Children's Research Institute
2022
MRC Biostatistics Unit
2022
ORCID
2021
Ibero American University
2020
The University of Melbourne
2016-2019
In higher income countries, social disadvantage is associated with arthritis prevalence; however, less known about prevalence or determinants in low to middle countries (LMICs). We assessed by age and sex, marital status occupation, as two key parameters of socioeconomic position (SEP), using data from the World Health Organization Study on global AGEing adult health (SAGE).SAGE Wave 1 (2007-10) includes nationally-representative samples older adults (≥50 yrs), plus smaller aged 18-49 yrs.,...
Objective: Conventional antidepressant treatments result in symptom remission 30% of those treated for major depressive disorder, raising the need effective adjunctive therapies. Inflammation has an established role pathophysiology and minocycline been shown to modify immune-inflammatory processes also reduce oxidative stress promote neuronal growth. This double-blind, randomised, placebo-controlled trial examined (200 mg/day, addition treatment as usual) disorder. investigated 200 mg/day...
Objective This study was conducted to estimate prevalence rates and factors associated with depressive symptoms indexed by the Centre for Epidemiological Studies‐Depression (CES‐D‐10) score in a large sample of community‐dwelling healthy older adults from Australia United States. Convergent divergent validity CES‐D‐10 were also examined. Methods A total 19 114 individuals aged greater than or equal 65 years old enrolled primary prevention clinical trial. Depressive classified using 8 10....
OBJECTIVES To investigate the association between depressive symptoms and several medical morbidities, their combination, in a large older population. DESIGN Cross‐sectional study of baseline data from ASPirin Reducing Events Elderly (ASPREE) trial. SETTING Multicentric conducted Australia United States. PARTICIPANTS A total 19,110 adults (mean age = 75 years [standard deviation ±4.5]). MEASUREMENTS Depressive were measured using Center for Epidemiological Studies Depression (CES‐D 10)...
Perturbations of the intestinal microbiota have been associated with mental health disorders, including major depressive disorder (MDD). Therefore, faecal transplantation (FMT) holds promise as a microbiota-modulating treatment for MDD. Yet, to date, there are no published controlled studies evaluating use FMT This study aimed address this gap by feasibility, acceptability, and safety MDD.The was an 8-week, double-blind, 2:1 parallel group, randomized pilot trial (n = 15) enema-delivered 10)...
Abstract Background Longitudinal cohort studies across the lifespan suggest an association between ultra-processed food (UPF) and depression. However, effect of UPF on depression mental health in older adults has not been determined. Therefore, this study investigated depressive symptoms community-dwelling adults. Methods A pragmatic target trial was designed emulated using ASPirin Reducing Events Elderly longitudinal data. Participants were (≥ 70 years) Australia. We specified protocol a...
Abstract Background High incidence rates of gastrointestinal tract cancers have been reported in the Caspian region Iran. This study aimed to: 1) describe geographical spatial patterns cancer based on registry data and, 2) determine whether clusters statistical significance exist. Methods The Babol Cancer Registry, which covers two major northern Iranian provinces Mazandaran and Golestan (total population = 4,484,622) was used to identify new cases during 2001 2005. Age-specific were...
BACKGROUND The purpose of this study was to determine the efficacy a clinician referral and exercise program in improving levels quality life for men with prostate cancer. METHODS This multicenter cluster randomized controlled trial Melbourne, Australia comprising 15 clinicians: 8 clinicians were refer eligible participants (n = 54) 12‐week 2 supervised gym sessions 1 home‐based session per week, 7 follow usual care 93). primary outcome self‐reported physical activity; secondary outcomes...
The aim of this project was to detail the costs associated with high prevalence mental disorders (depression, anxiety-related and substance use) in Australia, using community-based, nationally representative survey data.Respondents diagnosed, within preceding 12 months, Confidentialised Unit Record Files 2007 National Survey Mental Health Wellbeing were analysed. use healthcare resources (hospitalisations, consultations medications), productivity loss, income tax loss welfare benefits...
Abstract Background We aimed to examine the relationship between musculoskeletal deterioration and all‐cause mortality in a cohort of women studied prospectively over decade. Methods A 750 aged 50–94 years was followed for decade after femoral neck bone mineral density (BMD) appendicular lean mass (ALM) were measured using dual energy X‐ray absorptiometry, conjunction with comorbidities, health behaviour data, other clinical measures. The outcome identified from Australian National Deaths...
Depression is associated with increased inflammation, which may precede its onset, especially in older people. Some preclinical data suggest potential antidepressant effects of aspirin, supported by limited observational suggesting lower rates depression individuals treated aspirin. There currently appears to be no evidence-based pharmacotherapies for the primary prevention depression.To determine whether low-dose aspirin (100 mg) reduces risk healthy adults.This double-blinded,...
Abstract Background Inflammation contributes to the pathophysiology of major depressive disorder (MDD), and anti-inflammatory strategies might therefore have therapeutic potential. This trial aimed determine whether adjunctive aspirin or rosuvastatin, compared with placebo, reduced symptoms in young people (15–25 years). Methods YoDA-A, Youth Depression Alleviation Anti-inflammatory Agents, was a 12-week triple-blind, randomised, controlled trial. Participants were (aged 15–25 years)...
Objective: Oxidative stress, inflammation and heavy metals have been implicated in the aetiology of autistic disorder. N-acetyl cysteine has shown to modulate these pathways, providing a rationale trial for There are now two published pilot studies suggesting efficacy, particularly symptoms irritability. This study aimed explore if is useful treatment Method: was placebo-controlled, randomised clinical 500 mg/day oral over 6 months, addition as usual, children with Diagnostic Statistical...
<h3>Importance</h3> Previous unblinded clinical trials suggested that the intranasal route of naloxone hydrochloride was inferior to widely used intramuscular for reversal opioid overdose. <h3>Objective</h3> To test whether a dose administered intranasally is as effective same intramuscularly in reversing <h3>Design, Setting, and Participants</h3> A double-blind, double-dummy randomized trial conducted at Uniting Medically Supervised Injecting Centre Sydney, Australia. Clients center were...
Participation in mammographic screening for breast cancer Australia is approximately 54% among the general population, but women from some culturally and linguistically diverse (CALD) backgrounds lower. BreastScreen Victoria apply strategies to increase including reminder letters phone calls; however, these are usually provided English. Using intervention generated Ophelia (OPtimise HEalth LIteracy Access) community co-design process, translated mammography in-language calls were tested...
Low handgrip strength (HGS) is a measure of poor skeletal muscle performance and marker ill health frailty. Muscle quality (MQ) relative to mass. We aimed develop normative data for HGS MQ, report age-related prevalence low determine the relationship with age, anthropometry, body composition women in Australia.