A5078046333- Primary Care and Health Outcomes
- Cardiac Arrest and Resuscitation
- Health Systems, Economic Evaluations, Quality of Life
- Chronic Disease Management Strategies
- Healthcare Policy and Management
- Medication Adherence and Compliance
- Blood Pressure and Hypertension Studies
- Trauma and Emergency Care Studies
- Pharmaceutical Practices and Patient Outcomes
- Emergency and Acute Care Studies
- Cardiac Health and Mental Health
- Patient Satisfaction in Healthcare
- Antibiotic Use and Resistance
- Urinary Tract Infections Management
- Medical Malpractice and Liability Issues
- Innovations in Medical Education
- Healthcare Systems and Technology
- Health disparities and outcomes
- Physical Activity and Health
- Patient Safety and Medication Errors
- Mobile Health and mHealth Applications
- Diversity and Career in Medicine
- Health Promotion and Cardiovascular Prevention
- Disaster Response and Management
- Global Health Workforce Issues
Ollscoil na Gaillimhe – University of Galway
2016-2025
Trials Methodology Research Network
2017-2025
Harvard University
2013-2025
Center for Systems Biology
2025
Health Research Board
2009-2024
University College Dublin
1992-2024
University College Cork
2006-2024
University of South Australia
2024
Beaumont Hospital
2024
Trinity College Dublin
2003-2023
Edoxaban is a direct oral factor Xa inhibitor with proven antithrombotic effects. The long-term efficacy and safety of edoxaban as compared warfarin in patients atrial fibrillation not known.We conducted randomized, double-blind, double-dummy trial comparing two once-daily regimens 21,105 moderate-to-high-risk (median follow-up, 2.8 years). primary end point was stroke or systemic embolism. Each regimen tested for noninferiority to during the treatment period. principal major bleeding.The...
Introduction. Multimorbidity is common among the heterogeneous primary care population, but little data exist on its association with health utilization or cost. Objective. The aim of this observational study was to examine prevalence and associated cost patients multimorbidity. Methods. All >50 years age were eligible for which took place in three practices West Ireland. Chronic medical conditions secondary identified through patient record review. Results. In a sample 3309 community,...
<h3>Background</h3> Physical inactivity is a major, potentially modifiable, risk factor for cardiovascular disease, cancer, and other chronic diseases. Effective, simple, generalisable interventions that will increase physical activity in populations are needed. <h3>Aim</h3> To evaluate the effectiveness of smartphone application (app) to primary care. <h3>Design setting</h3> An 8-week, open-label, randomised controlled trial rural, care west Ireland. <h3>Method</h3> Android users >16...
Abstract Background The benefits of Peer Assisted Learning (PAL) are well established with positive effects on examination scores, student satisfaction and personal professional development reported. PAL is increasingly utilised as a resource within medical education where the restrictions resources have forced teachers to look at creating new educational environments which can be delivered lower cost. This study sought evaluate processes work emphasis research date has largely been...
The aims of the PRIME study (Prevalence, Impact and Cost Chronic Pain) were 3-fold: (1) to determine point prevalence chronic pain in Ireland; (2) compare psychological physical health profiles those with without pain; (3) explore a predictive model pain-related disability. A postal survey 3136 people was conducted representative community-based sample adults. Measures obtained for sociodemographic variables, well-being, depressive symptoms, presence pain, severity, disability, illness...
A prospective cohort study was set up to investigate a possible association between antibiotic prescribing and resistance of E. coli urinary tract infection in the community. Participation patients with obtained through an opt-out methodology. This short paper reports on acceptability recruitment approach. Participating practices (22) were requested send urine sample from all presenting symptoms infection. Upon receipt laboratory, letter explaining study, form freepost envelope sent adult...
Background Appropriate understanding of health information by patients with cardiovascular disease (CVD) is fundamental for better management risk factors and improved morbidity, which can also benefit their quality life. Objectives To assess the relationship between literacy health-related life (HRQoL) in ischaemic heart (IHD), to investigate role sociodemographic clinical variables as possible confounders. Methods Cross-sectional study IHD recruited from a stratified sample general...
Abstract Background The optimal approach to the diagnosis of atrial fibrillation in primary care is unclear. Aim To determine if external loop recorder (ELR) screening improves detection community dwelling adults with a CHA2DS2-VASc score greater than two. Design Randomised cross-over clinical trial. Methods Community ≥55 years two, who were deemed suitable for and oral anticoagulation by their general practitioner randomly assigned immediate or delayed ELR monitoring. intervention period...
The physiological role of the platelet-secreted protein thrombospondin (TSP) is poorly understood, although it has been postulated to be involved in platelet aggregation and cellular adhesion. In this report, TSP isolated from human platelets was found promote, vitro, cell-substratum adhesion a variety cells, including platelets, melanoma muscle endothelial fibroblasts, epithelial cells. adhesion-promoting activity species independent, specific, not due contamination by fibronectin,...
<h3>Abstract</h3> <b>Objective</b>: To see whether care provided by general practitioners to non-emergency patients in an accident and emergency department differs significantly from usual staff terms of process, outcome, comparative cost. <b>Design</b>: A randomised controlled trial. <b>Setting</b>: busy inner city hospital9s which employed three local on a sessional basis. <b>Patients</b>: All new attenders categorised the triage system as "semiurgent" or "delay acceptable." 66% all were...
Blood-brain barrier (BBB) regulation involves the coordinated interaction of intercellular adherens and tight junctions in response to stimuli. One such stimulus, shear stress, has been shown upregulate brain microvascular endothelial cell (BMvEC) function, although our knowledge signaling mechanisms involved is limited. In this article, we examined hypothesis that VE-cadherin can transmit signals junction occludin with consequences for pTyr-occludin function. initial studies, chronic...
<b>Objective</b> To test the effectiveness of a complex intervention designed, within theoretical framework, to improve outcomes for patients with coronary heart disease. <b>Design</b> Cluster randomised controlled multicentre trial. <b>Setting</b> General practices in Northern Ireland and Republic Ireland, regions different healthcare systems. <b>Participants</b> 903 established disease registered one 48 practices. <b>Intervention</b> Tailored care plans (practice based training prescribing...
Sexual problems are common among people with coronary heart disease and can adversely affect patients' quality of life. GPs ideally placed to deal these problems. Research suggests that reluctant address sexual but little is known about what currently takes place in practice. The aim this study was examine GPs' self-reported behaviour attitudes discussing disease. Design: A cross-sectional survey which administered 230 postal questionnaires a nationally representative, stratified random...