A5020976081- Cardiovascular and exercise physiology
- Heart Rate Variability and Autonomic Control
- Blood Pressure and Hypertension Studies
- Health Systems, Economic Evaluations, Quality of Life
- Gestational Diabetes Research and Management
- Non-Invasive Vital Sign Monitoring
- Cardiac Health and Mental Health
- Nutritional Studies and Diet
- Multiple Sclerosis Research Studies
- Cardiovascular Effects of Exercise
- Pregnancy and preeclampsia studies
- Chronic Disease Management Strategies
- COVID-19 epidemiological studies
- High Altitude and Hypoxia
- Statistical Methods and Bayesian Inference
- Delphi Technique in Research
- Sodium Intake and Health
- Statistical Methods and Inference
- Respiratory Support and Mechanisms
- Gastric Cancer Management and Outcomes
- Esophageal Cancer Research and Treatment
- Advanced Causal Inference Techniques
- Spine and Intervertebral Disc Pathology
- Cardiovascular Syncope and Autonomic Disorders
- Management of metastatic bone disease
Universitat de Barcelona
2025
University Hospital Galway
2021-2024
Ollscoil na Gaillimhe – University of Galway
2015-2024
Health Research Board
2018-2024
Wayne State University
2014-2023
Weatherford College
2023
Letterkenny University Hospital
2023
Sahlgrenska University Hospital
2023
University of Gothenburg
2023
Michigan United
2015-2023
<h3>Background</h3> Physical inactivity is a major, potentially modifiable, risk factor for cardiovascular disease, cancer, and other chronic diseases. Effective, simple, generalisable interventions that will increase physical activity in populations are needed. <h3>Aim</h3> To evaluate the effectiveness of smartphone application (app) to primary care. <h3>Design setting</h3> An 8-week, open-label, randomised controlled trial rural, care west Ireland. <h3>Method</h3> Android users >16...
4004 Background: The optimum combination curative approach to locally advanced adenocarcinoma of the esophagus and esophago-gastric junction (AEG) is unknown. A key question whether neoadjuvant multimodal therapy, specifically CROSS (carboplatin/paclitaxel, 41.4Gy radiation therapy), superior peri-operative chemotherapeutic regimens including modified MAGIC (epirubicin, cisplatin (oxaliplatin), 5-FU (capecitabine)) more latterly FLOT (docetaxel, 5-FU, leucovorin, oxaliplatin). Neo-AEGIS was...
The optimum curative approach to adenocarcinoma of the oesophagus and oesophagogastric junction is unknown. We aimed compare trimodality therapy (preoperative radiotherapy with carboplatin plus paclitaxel [CROSS regimen]) contemporaneous perioperative chemotherapy regimens (epirubicin cisplatin or oxaliplatin fluorouracil capecitabine [a modified MAGIC regimen] before 2018 fluorouracil, leucovorin, oxaliplatin, docetaxel [FLOT] subsequently).
Importance Gestational diabetes is a common complication of pregnancy and the optimal management uncertain. Objective To test whether early initiation metformin reduces insulin or improves fasting hyperglycemia at gestation weeks 32 38. Design, Setting, Participants Double-blind, placebo-controlled trial conducted in 2 centers Ireland (one tertiary hospital one smaller regional hospital). were enrolled from June 2017 through September 2022 followed up until 12 weeks’ postpartum. comprised...
Translational Statistics proposes to promote the use of within research and improve communication statistical findings in an accurate accessible manner diverse audiences. When models become more complex, it becomes harder evaluate role explanatory variables on response. For example, interpretation effect predictors regression where interactions or smoothing splines are included can be challenging. Informative graphical representations play a critical translational role; static nomograms one...
Symptoms of sleep disturbance are common and may represent important modifiable risk factors stroke. We evaluated the association between a spectrum symptoms acute stroke in an international setting.The INTERSTROKE study is case-control patients presenting with first controls matched by age (±5 years) sex. Sleep previous month were assessed through questionnaire. Conditional logistic regression estimated stroke, expressed as odds ratios (ORs) 95% CIs. The primary model adjusted for age,...
Quantifying the proportion of dementia attributable to highly prevalent modifiable risk factors, such as hypertension, is important in informing effective prevention strategies. We aim quantify population fraction (PAF) hypertension for (the cases that would not occur if was eliminated) at global, regional, and national levels.In this study, we searched international governmental websites data reporting (according 10-year age categories) prevalence. MEDLINE studies from diagnosis database...
Abstract Background The optimal approach to the diagnosis of atrial fibrillation in primary care is unclear. Aim To determine if external loop recorder (ELR) screening improves detection community dwelling adults with a CHA2DS2-VASc score greater than two. Design Randomised cross-over clinical trial. Methods Community ≥55 years two, who were deemed suitable for and oral anticoagulation by their general practitioner randomly assigned immediate or delayed ELR monitoring. intervention period...
295 Background: The optimum combination curative approach to locally advanced adenocarcinoma of the esophagus and esophago-gastric junction (AEG) remains controversial, specifically whether multimodal therapy or perioperative chemotherapy is superior. Neo-AEGIS was designed as first randomized clinical trial (RCT) directly compare CROSS regimen (carboplatin/paclitaxel, 41.4Gy radiation therapy) with a modified MAGIC (epirubicin, cisplatin (oxaliplatin), 5-FU (capecitabine)) (pre-2018) more...
This is the first study to examine risk factors for diabetic foot ulceration in Irish general practice.To determine prevalence of established a community-based cohort, and explore potential estimated glomerular filtration rate (eGFR) act as novel factor.A prospective observational study.Patients with diabetes attending 12 (of 17) invited practices were screening. Validated clinical tests carried out at baseline assess vascular sensory impairment deformity. Ulcer incidence was ascertained by...
Sedentary lifestyles are now becoming a major concern for governments of developed and developing countries with physical inactivity related to increased all-cause mortality, lower quality life, risk obesity, diabetes, hypertension many other chronic diseases. The powerful onboard computing capacity smartphones, along the unique relationship individuals have their mobile phones, suggests that devices potential influence behavior. However, no previous trials been conducted using smartphone...
Importance Psychosocial stress is considered a modifiable risk factor for stroke. Given the prevalence of chronic and acute exposure to stress, it represents potentially attractive target population-health interventions. Objectives To determine association psychosocial with stroke explore factors that might modify in large international population. Design, Setting, Participants INTERSTROKE an retrospective case-control study first 32 countries Asia, North South America, Europe, Australia,...
Nebulised unfractionated heparin may attenuate COVID-19 ARDS by reducing pulmonary microvascular thrombosis, blocking SARS-CoV-2 entry into cells, and decreasing lung inflammation. patients with a raised D-dimer have areas of hypoperfusion on CT perfusion scans the increased mortality risk. This was phase Ib/IIa open-label multi-centre, randomised controlled trial. The study designed to evaluate whether nebulised decreased concentrations, safety as co-primary outcome. Forty were recruited,...
Aim: This study investigates the association between ApoE genotype, plasma cholesteryl ester (CE) levels, and Alzheimer’s disease (AD) status, with a focus on CE(20:4) CE(22:5) levels as potential indicators of lipid metabolism alterations in AD patients. Methods: Publicly available metabolomics data (DOI: 10.3233/JAD-215448) from 94 patients 62 controls aged 55 older were re-analyzed. CE examined using non-parametric tests due to non-normal overall distribution. Comparisons stratified by...
Abstract Objectives Human tear analysis holds promise for biomarker discovery, but its clinical utility is hindered by the lack of standardized reference values, limiting interindividual comparisons. This study aimed at developing a protocol normalizing metabolomic data from human tears, enhancing potential identification. Methods Tear profiling was conducted on 103 donors (64 females, 39 males, aged 18–82 years) without ocular pathology, using AbsoluteIDQ™ p180 Kit targeted metabolomics. A...
Chronic diseases tend to depend on a large number of risk factors, both environmental and genetic. Average attributable fractions were introduced by Eide Gefeller as way partitioning overall disease burden into contributions from individual factors; this may be useful in deciding which factors target interventions. Here, we introduce new estimation methods for average that are appropriate case–control designs prospective studies. Confidence intervals, derived using Monte Carlo simulation,...
When oxygen delivery to active muscle is insufficient meet the metabolic demand during exercise, metabolites accumulate and stimulate skeletal afferents, inducing a reflex increase in blood pressure, termed metaboreflex. In healthy individuals, metaboreflex activation (MMA) submaximal exercise increases arterial pressure primarily via an cardiac output (CO), as little peripheral vasoconstriction occurs. This CO partially restores flow ischemic muscle. However, we recently demonstrated that...
Depression has been reported to be a risk factor of acute stroke, based largely on studies in high-income countries. In the INTERSTROKE study, we explored contribution depressive symptoms stroke and 1-month outcome across regions world, within subpopulations by type.The is an international case-control study factors first conducted 32 Cases were patients with CT- or MRI-confirmed incident hospitalized controls matched for age, sex, sites. Standardized questions asked about self-reported...
While low sodium intake (<2.3 g/day) is recommended, there uncertainty about long-term feasibility and effects on cardiorenal biomarkers in populations with moderate intake.In two phase IIb, feasibility, randomised, parallel, open-label, controlled, single-centre trials, individuals aged >40 years stable blood pressure (BP), without heart failure or postural hypotension were randomised to intensive dietary counselling (target <2.3 usual care between March 2016 July 2018. One trial included...
Oral anti-cancer medications (OAMs) are being used increasingly within cancer care. OAMs offer the potential to improve patient convenience and increase hospital capacity. The clinical assessment for each cycle of requires specialist review often performed in hospital-based oncology units. Consequently, any improvement expediency or increased capacity that can is not realised. This study aimed develop pilot patients receiving by an Advanced Nurse Practitioner (ANP) a community-based...
Reliable remote cognitive testing could provide a safer assessment of impairment in multiple sclerosis (MS) during the COVID-19 pandemic and thereafter. Here we aimed to investigate reliability feasibility administering Brief International Cognitive Assessment for MS (BICAMS) Trail-Making Test (TMT) people with online. Between-group differences on BICAMS TMT were examined sample 68 participants. Group 1 (N = 34) was tested in-person pre-pandemic. 2 remotely. Within-group virtual...
Blood flow restriction training (BFRT) increases muscle mass, strength, and endurance. There has been minimal consideration of the reflex cardiovascular responses that could be elicited during BFRT sessions. We showed low-intensity exercise may trigger large in blood pressure sympathetic activity due to metaboreflex activation. Thus, we urge caution when employing BFRT, especially patients whom exaggerated occur cause sudden, adverse events.