A5071535693- Child Development and Digital Technology
- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Social Media and Politics
- Radio, Podcasts, and Digital Media
- Impact of Technology on Adolescents
- ICT Impact and Policies
- Gastric Cancer Management and Outcomes
- Advanced Radiotherapy Techniques
- Literacy, Media, and Education
- Privacy, Security, and Data Protection
- Media Studies and Communication
- Colorectal Cancer Treatments and Studies
- Esophageal Cancer Research and Treatment
- Bullying, Victimization, and Aggression
- Prostate Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Cultural Industries and Urban Development
- Media and Digital Communication
- Hate Speech and Cyberbullying Detection
- Research in Social Sciences
- Traumatic Brain Injury Research
- Genetic factors in colorectal cancer
- Digital Games and Media
- Technology Use by Older Adults
Beaumont Hospital
2016-2025
Cancer Trials Ireland
2016-2025
Quinnipiac University
2024
Royal College of Surgeons in Ireland
2013-2023
Technological University Dublin
2018-2021
St. Luke's Hospital
2010-2020
KU Leuven
2019
Indiana University Hospital
2018
University of Ulster
2016-2017
University of Glasgow
2017
4004 Background: The optimum combination curative approach to locally advanced adenocarcinoma of the esophagus and esophago-gastric junction (AEG) is unknown. A key question whether neoadjuvant multimodal therapy, specifically CROSS (carboplatin/paclitaxel, 41.4Gy radiation therapy), superior peri-operative chemotherapeutic regimens including modified MAGIC (epirubicin, cisplatin (oxaliplatin), 5-FU (capecitabine)) more latterly FLOT (docetaxel, 5-FU, leucovorin, oxaliplatin). Neo-AEGIS was...
Neoadjuvant therapy is increasingly the standard of care in management locally advanced adenocarcinoma oesophagus and junction (AEG). In randomised controlled trials (RCTs), MAGIC regimen pre- postoperative chemotherapy, CROSS preoperative chemotherapy combined with radiation, were superior to surgery only RCTs that included AEG but not powered on this cohort. No completed RCT has directly compared neoadjuvant or perioperative chemoradiation. The Neo-AEGIS trial, uniquely AEG, including...
Modern three-dimentional radiotherapy is based upon CT. For rectal cancer, this relies target definition on CT, which not the optimal imaging modality. The major limitation of CT its low inherent contrast resolution. Targets defined by MRI could facilitate smaller, more accurate, tumour volumes than Our study reviewed and planning data for 10 patients with locally advanced cancer (defined as < 6 cm from anal verge digital examination). Tumour volume location were compared sagittal...
The aim of this study was to evaluate the MR findings anal carcinoma using an external pelvic phased-array coil before and after chemoradiation treatment. 15 patients with canal underwent T(2) weighted short-tau inversion recovery (STIR) imaging chemoradiation. Images were reviewed in consensus by two radiologists. At pre-treatment imaging, tumour size stage, signal intensity infiltration adjacent structures recorded. repeated immediately chemoradiation, every 6 months for first year then...
To date, there is no uniform consensus on whether tumour regression grade (TRG) predictive of outcome in rectal cancer. Furthermore, the lack standardization TRG grading a major source variability published studies. The aim this study was to evaluate prognostic impact cohort patients with locally advanced cancer treated neoadjuvant chemoradiation therapy (CRT). In addition Mandard TRG, we utilized four systems modified from system and applied them assess which most informative.One-hundred...
That children have a right to protection when they go online is an internationally well-established principle, upheld in laws that seek safeguard from abuse and exploitation. However, children’s own transgressive behaviour can test the boundaries of this regime, creating new dilemmas for lawmakers world over. This article examines policy response both Global North South young people’s may challenge adult conceptions what acceptable, within existing legal frameworks. It asks whether...
Objective: To evaluate the effectiveness of an automated interactive prompting technology in supporting morning routine persons with acquired brain injury. The included maintaining personal hygiene and dressing. Setting: An inpatient neurorehabilitation hospital. Participants: Persons injury who required when following their ( n = 24), but were not limited by physical disability or dysphasia, took part study. Participants (67% traumatic injury) had impairment on indices memory executive...
Abstract Background There is currently no consensus on surveillance following curative treatment of esophageal cancer; re-investigation largely relying symptom triggers which may delay detection recurrence and impact survival. We hypothesised that intensive was more likely to detect recurrent or new cancer at a curable stage this study examined the outcomes policy. Patients Methods A prospective database curatively treated oesophageal carcinoma patients interrogated for with disease detected...
Responses to neoadjuvant chemoradiotherapy for locally advanced rectal cancer are not uniform. The phosphatidylinositol-3 kinase (PI3K) and mitogen-activated protein (MAPK) pathways involved in tumorigenesis treatment resistance many cancers; therefore, targeting these could enhance response chemoradiotherapy. A panel of colorectal (CRC) cell lines (n = 10) with varying PI3K MAPK mutational backgrounds were treated combinations 5-Flourouracil (5-FU), radiation, the inhibitor copanlisib,...
Children can easily bypass the mechanisms adopted by apps to verify their age and, thereby, be exposed privacy and safety threats. We identified how top 10 social communication among underage users apply limits.
The future of radio is now much less obvious and clear than it appeared 10 years ago. Instead a transition from analog to digital audio broadcasting (DAB), there selection alternative technological options for delivery. This article studies how 43 people in key positions related the industry four European countries Canada view which delivery technologies they consider will be most successful. In addition, analyzes motives reasons why certain are seen as more promising. Finally, presents...
Machinima is a new form of creative digital filmmaking that leverages the real time graphics rendering computer game engines. Because low barrier to entry, machinima has become popular medium for hobbyists and novices while still retaining borrowed conventions from professional filmmaking. Can novice creators benefit creativity support tools? A preliminary study shows generally have difficulty adhering cinematographic conventions. We identify document four cinematic typically violate. report...
TPS4145 Background: Neoadjuvant therapy is increasingly the standard of care in management locally advanced adenocarcinoma esophagus and junction (AEG). The MAGIC CROSS regimens were superior to surgery only randomized controlled trials (RCTs) that included AEG but not powered on this cohort, no completed RCT has directly compared neoadjuvant chemotherapy chemoradiation. This trial, uniquely AEG, including comprehensive modern staging, compares both these Level I regimens. Methods: open...
The harmful effects of bullying and harassment on children have long been concern to parents, educators, policy makers. online world presents a new environment in which vulnerable can be victimized space where perpetrators find ways perform acts harassment. While is often considered an extension persistent offline behavior, according EU Kids Online (2011), the most common form person, face-to-face. With rise use mobile Internet technologies, this balance changing. Increased levels more time...