A5001831939- Esophageal Cancer Research and Treatment
- Esophageal and GI Pathology
- Gastric Cancer Management and Outcomes
- Surgical Simulation and Training
- Cardiac, Anesthesia and Surgical Outcomes
- Advanced Chemical Sensor Technologies
- Colorectal Cancer Surgical Treatments
- Metabolomics and Mass Spectrometry Studies
- Cancer Genomics and Diagnostics
- Anatomy and Medical Technology
- Lung Cancer Diagnosis and Treatment
- Gastroesophageal reflux and treatments
- Analytical Chemistry and Chromatography
- Mass Spectrometry Techniques and Applications
- Innovations in Medical Education
- Gastrointestinal Tumor Research and Treatment
- Lung Cancer Treatments and Mutations
- Biochemical Analysis and Sensing Techniques
- Radiomics and Machine Learning in Medical Imaging
- Cancer, Lipids, and Metabolism
- Patient Safety and Medication Errors
- RNA modifications and cancer
- Olfactory and Sensory Function Studies
- Colorectal Cancer Screening and Detection
- Pelvic and Acetabular Injuries
Imperial College London
2016-2025
Hammersmith Hospital
2016-2025
Imperial College Healthcare NHS Trust
2010-2025
University Hospitals Birmingham NHS Foundation Trust
2024
Queen Elizabeth Hospital
2024
University of Birmingham
2024
University College London
2023-2024
University of London
2023-2024
Amsterdam University Medical Centers
2024
Los Angeles Medical Center
2024
This study aims to report short-term clinical and oncological outcomes from the international transanal Total Mesorectal Excision (taTME) registry for benign malignant rectal pathology.TaTME is latest minimally invasive technique pioneered facilitate difficult pelvic dissections. Outcomes have been published small cohorts, but larger series can further assess safety efficacy of taTME in wider surgical population.Data were analyzed 66 registered units 23 countries. The primary endpoint was...
Total mesorectal excision (TME) is an essential component of surgical management rectal cancer. Both open and laparoscopic TME have been proven to be oncologically safe. However, it remains a challenge achieve complete with clear circumferential resections margin (CRM) the conventional transabdominal approach, particularly in mid low tumours. Transanal (TaTME) was developed improve oncological functional outcomes patients An international, multicentre, superiority, randomised trial designed...
Objective: To determine the incidence of anastomotic-related morbidity following Transanal Total Mesorectal Excision (TaTME) and identify independent risk factors for failure. Background: Anastomotic leak its sequelae are dreaded complications gastrointestinal surgery. TaTME is a recent technique rectal resection, which includes novel anastomotic techniques. Methods: Prospective study consecutive reconstructed cases recorded over 30 months in 107 surgical centers across 29 countries. Primary...
Esophageal adenocarcinomas are associated with a dismal prognosis. Deciphering the evolutionary history of this disease may shed light on therapeutically tractable targets and reveal dynamic mutational processes during course following neoadjuvant chemotherapy (NAC). We exome sequenced 40 tumor regions from 8 patients operable esophageal adenocarcinomas, before after platinum-containing NAC. This revealed genomic landscape presence heterogeneous driver mutations, parallel evolution, early...
The OligoMetastatic Esophagogastric Cancer (OMEC) project aims to provide clinical practice guidelines for the definition, diagnosis, and treatment of esophagogastric oligometastatic disease (OMD).
To investigate the influence of image display location on endoscopic task performance in surgery.The system is only visual interface between surgeon or interventionist and operative field. Several factors correct perceptual processing manipulation from images. One these with respect to site. The present study was conducted whether improves under two conditions: when surgeon-to-monitor axis aligned forearm-instrument motor close operator's workspace.An (tying an intracorporeal surgeon's knot)...
To compare short-term outcomes of open and minimally invasive esophagectomy (MIE) for cancer.Numerous studies have demonstrated the safety possible advantages MIE in selected cohorts patients. The increasing use is not coupled with conclusive evidence its benefits over "open" esophagectomy, especially absence randomized trials.Hospital Episode Statistics data were analyzed from April 2005 to March 2010. This a routinely collected database all English National Health Service Trusts. Office...
Surgical operative performance benefits from analysis of the mechanisms underlying technical errors committed during surgery.Prospective study using Observational Clinical Human Reliability Assessment (OCHRA) system and complete unedited videotapes operations.Three National Health Service hospitals within United Kingdom.Two hundred consecutive patients with symptomatic gallstone disease.Elective laparoscopic cholecystectomy for disease by surgeons, who were blind to nature objectives study,...
This study investigates the effects of surgeons' stress levels and coping strategies on surgical performance during simulated operations.Thirty surgeons carried out each a non-crisis crisis scenario operation. Surgeons' were assessed by several measures: self-assessments observer ratings stress, heart rate, rate variability, salivary cortisol. Coping explored qualitatively quantified to score. Experience in surgery was included as an additional predictor. Outcome measures consisted technical...
The present study assessed whether exhaled breath analysis using Selected Ion Flow Tube Mass Spectrometry could distinguish esophageal and gastric adenocarcinoma from noncancer controls.The majority of patients with upper gastrointestinal cancer advanced disease, resulting in poor long-term survival rates. Novel methods are needed to diagnose potentially curable malignancies.A Profile-3 instrument was used for volatile organic compounds (VOCs) within samples. All participants had undergone...
<h3>Objective</h3> This study assessed the associations between hospital volume, resection rate and survival of oesophageal gastric cancer patients in England. <h3>Design</h3> 62 811 diagnosed with or 2004 2008 were identified from a national population-based registration Hospital Episode Statistics-linked dataset. Cox regression analyses used to assess all-cause mortality according volume rate, adjusting for case-mix variables (sex, age, socioeconomic deprivation, comorbidity type cancer)....
Exhaled breath analysis of volatile organic compounds (VOCs) has great potential in terms disease diagnosis and measuring physiological response to treatment. In this study, selected ion flow tube mass spectrometry (SIFT-MS) been applied for the quantification VOCs exhaled from 3 groups patients, viz., those with esophago-gastric cancer, noncancer diseases upper gastro-intestinal tract, a healthy gastrointestinal tract cohort. A total 17 have investigated study. The concentrations 4 VOCs,...
Neoadjuvant therapy is increasingly the standard of care in management locally advanced adenocarcinoma oesophagus and junction (AEG). In randomised controlled trials (RCTs), MAGIC regimen pre- postoperative chemotherapy, CROSS preoperative chemotherapy combined with radiation, were superior to surgery only RCTs that included AEG but not powered on this cohort. No completed RCT has directly compared neoadjuvant or perioperative chemoradiation. The Neo-AEGIS trial, uniquely AEG, including...
<h3>Importance</h3> Complex surgical interventions are inherently prone to variation yet they not objectively measured. The reasons for outcome differences following cancer surgery unclear. <h3>Objective</h3> To quantify skill within advanced laparoscopic procedures and its association with histopathological clinical outcomes. <h3>Design, Setting, Participants</h3> This analysis of data video from the Australasian Laparoscopic Cancer Rectum (ALaCaRT) 2-dimensional/3-dimensional (2D3D)...