A5083953328- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Colorectal Cancer Screening and Detection
- Anorectal Disease Treatments and Outcomes
- Anatomy and Medical Technology
- Surgical Simulation and Training
- Adenosine and Purinergic Signaling
- Neuroscience of respiration and sleep
- Gastroesophageal reflux and treatments
- Higher Education Research Studies
- COVID-19 and healthcare impacts
- Ion Channels and Receptors
- Minimally Invasive Surgical Techniques
- Augmented Reality Applications
- Mosquito-borne diseases and control
- Gastrointestinal motility and disorders
- Financial Reporting and Valuation Research
- Cardiac tumors and thrombi
- IgG4-Related and Inflammatory Diseases
- Simulation-Based Education in Healthcare
- Gastric Cancer Management and Outcomes
- Respiratory and Cough-Related Research
- Radiomics and Machine Learning in Medical Imaging
- Freshwater macroinvertebrate diversity and ecology
- Gastrointestinal disorders and treatments
East Suffolk and North Essex NHS Foundation Trust
2020-2023
Colchester Hospital
2010-2023
National Ice Centre
2011-2018
St Thomas' Hospital
2009
St. Thomas Hospital
2008
University College London
2003-2006
The Royal Free Hospital
2003-2006
Kent and Sussex Hospital
2004
University of Cambridge
2001
Earlham College
1982
BACKGROUND: Complete tumor regression may develop after neoadjuvant chemoradiation therapy for distal rectal cancer. Studies have suggested that selected patients with complete clinical response avoid radical surgery and close surveillance provide good outcomes no oncologic compromise. However, definition of is often imprecise vary between different studies. The aim this study to a clear in cancer addition actual endoscopic videos from managed nonoperatively. METHODS: Patients nonmetastatic...
This study aims to report short-term clinical and oncological outcomes from the international transanal Total Mesorectal Excision (taTME) registry for benign malignant rectal pathology.TaTME is latest minimally invasive technique pioneered facilitate difficult pelvic dissections. Outcomes have been published small cohorts, but larger series can further assess safety efficacy of taTME in wider surgical population.Data were analyzed 66 registered units 23 countries. The primary endpoint was...
Objective: To determine the incidence of anastomotic-related morbidity following Transanal Total Mesorectal Excision (TaTME) and identify independent risk factors for failure. Background: Anastomotic leak its sequelae are dreaded complications gastrointestinal surgery. TaTME is a recent technique rectal resection, which includes novel anastomotic techniques. Methods: Prospective study consecutive reconstructed cases recorded over 30 months in 107 surgical centers across 29 countries. Primary...
ATP contributes to mechanosensory transduction in the rat colorectum. P2X3 receptors are present on dorsal root ganglia (DRG) neurons that supply this area of gut. Previous studies have shown an increased role for inflamed tissues. We aimed investigate whether purinergic component exists during a model colitis. An vitro colorectal preparation was used distension release and evaluate antagonists distension-evoked sensory discharges pelvic nerve normal colitis preparations. DRG neuron...
BACKGROUND: Applications for natural orifice translumenal endoscopic surgery (NOTES) to access the abdominal cavity have increased in recent years. Despite potential advantages of transanal and transcolonic NOTES colorectal pathology, it has not been widely applied clinical setting. This study describes a series nine patients whom we performed retrograde (“Down-to-Up”) total mesorectal excision rectal cancer. MATERIALS AND METHODS: Under IRB approval, informed consent was obtained from each...
Transanal total mesorectal excision (TaTME) offers a promising alternative to the standard surgical abdominopelvic approach for rectal cancer. The aim of this study was report two-centre experience technique, focusing on short-term and oncological outcome.From May 2013 2015, 40 selected patients with histologically proven adenocarcinoma underwent TaTME in two institutions were prospectively entered an online international registry.Forty (80% men, mean body mass index 27.4 kg/m2 ) requiring...
Advances in neoadjuvant treatment have highlighted the phenomenon of complete clinical response (CCR) a proportion patients with rectal cancer. Radical surgery may be associated poor functional outcome and quality life has small but significant risk mortality. This study aimed to assess opinion colorectal surgeons on issues surrounding question nonoperative management who demonstrate after therapy.A questionnaire was sent members Association Coloproctology Great Britain Ireland regarding...
We used a simple experimental design to test for the effects of microcosm scaling on growth and survival mosquito, Culex pipiens. Microcosm mesocosm studies are commonly in ecology, there is often an assumption that doesn't affect outcomes. The implicit design; choice mesocosms may be arbitrary or based convenience cost. tested hypothesis scale would influence larvae due depth surface area effects. Larvae were predicted perform poorly microcosms both deep had small openings, buildup waste...
The aim was to document the outcomes of surgeons attending a cadaveric simulation course designed provide an introduction transanal total mesorectal excision (TaTME).This prospective observational study documenting from classroom and wet lab activities. Follow-up questionnaires were used monitor clinical activity after course.Outcomes 65 delegates 12 different countries seven courses are described. Median time insert close rectal purse-string 15 min (range 7-50 min) median complete...
Evidence of a role for purinergic signalling in visceral afferents involving P2X(2), P2X(3) and P2Y(1) receptors exists, which appears to be important during inflammation. This study aimed evaluate the degree interaction between adenosine 5'-triphosphate (ATP) other mediators that activate sensory nerves colorectum. Recordings from pelvic nerve were made application agents in-vitro colorectal preparation. Analysis allowed calculation single unit activity. When applied individually,...
The interest and adoption of transanal total mesorectal excision (TaTME) is growing worldwide, but evidence on nationwide implementation short-term outcomes scarce. This study aims to evaluate national results for this relatively new technique in the UK.All TaTME procedures performed UK recorded international registry between January 2013 2018 were analyzed. Surgeons who received training sent a survey regarding their experience with unit. Primary endpoint was composite "optimal pathology"...
Extracellular ATP and 5-hydroxytryptamine (5-HT) are both involved in visceral sensory pathways by interacting with P2X 5-HT(3) receptors, respectively. We have investigated the changes 5-HT(3)-mediated signalling pelvic afferent neurons mice deficient P2X(2) and/or P2X(3) subunits whole-cell recording of L(6)-S(2) dorsal root ganglion (DRG) multi-unit afferents colorectum. In wildtype DRG neurons, evoked transient, sustained or mixed (biphasic) inward currents. Transient currents were...
The virtual reality (VR) laparoscopic colorectal curriculum is a unique and innovative learning opportunity for surgical trainees. Although it can enhance the skills of senior surgeons, its main aim to introduce junior surgeons concept practice surgery before they might have perform such on patients in theatres. Based at Medical Simulation Centre Royal Free hospital London (http://www.rfh-simulator-centre.co.uk/), equips trainee with technical VR sigmoid colectomy independently objectively...
Total mesorectal excision remains the gold standard for surgical treatment rectal cancer to achieve excellent oncological outcomes. The transanal approach mesorectum was introduced complement conventional surgery so that technical difficulties related distal dissection could be overcome. Since its introduction, interest in has been growing and it appears benefits are maximal patients with mid-low where anatomical pathological factors present greatest challenges. Current evidence demonstrates...