A5052154118- Acute Ischemic Stroke Management
- Cerebral Venous Sinus Thrombosis
- Venous Thromboembolism Diagnosis and Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Stroke Rehabilitation and Recovery
- Neurosurgical Procedures and Complications
- Infectious Diseases and Tuberculosis
- Long-Term Effects of COVID-19
- Cerebrovascular and Carotid Artery Diseases
- Neurology and Historical Studies
- Air Quality and Health Impacts
- Climate Change and Health Impacts
- Bacterial Infections and Vaccines
- Mosquito-borne diseases and control
- Health, Environment, Cognitive Aging
- COVID-19 Clinical Research Studies
- Blood Coagulation and Thrombosis Mechanisms
- Multiple Sclerosis Research Studies
- Healthcare Systems and Public Health
- Blood Pressure and Hypertension Studies
- Human Health and Disease
- Peripheral Neuropathies and Disorders
- Tuberculosis Research and Epidemiology
- Heparin-Induced Thrombocytopenia and Thrombosis
- Traumatic Brain Injury and Neurovascular Disturbances
Aga Khan University
2016-2025
Aga Khan University
2004-2024
Aga Khan University Hospital
2008-2023
Sahlgrenska University Hospital
2023
Ollscoil na Gaillimhe – University of Galway
2023
University of Gothenburg
2023
Pakistan Institute of Medical Sciences
2022-2023
Liaquat National Hospital
2008-2022
Ziauddin University
2009-2022
Rashid Hospital
2022
Early control of elevated blood pressure is the most promising treatment for acute intracerebral haemorrhage. We aimed to establish whether implementing a goal-directed care bundle incorporating protocols early intensive lowering and management algorithms hyperglycaemia, pyrexia, abnormal anticoagulation, implemented in hospital setting, could improve outcomes patients with spontaneous
Fatigue is an unexplained but common and disabling symptom in MS. We assessed fatigue 71 patients with MS identified MS-fatigue (MSF) MS-nonfatigue (MSNF) groups. severity did not correlate regional or global MRI plaque load atrophy by conventional sequences. No significant differences were noted any measures between MSF MSNF suggest that brain disease topography does explain likely due to mechanisms poorly characterized MRI.
This study presents a large multicenter cohort of children with cerebral venous thrombosis from 5 centers in the United States and analyzes their clinical findings risk factors. Seventy patients were included (25 neonates, 35%). The age ranged 6 days to 12 years. Thirty-eight (55%) younger than months age, 28 (40%) male. Presenting features seizures (59%), coma (30%), headache (18%), motor weakness (21%). Common neurological decreased level consciousness (50%), papilledema cranial nerve...
Background and Purpose— The natural history, causative factors, outcomes of patients with cerebral venous thrombosis from Asia Middle East have not been well described. This descriptive multicenter study describes the results for in South East. Methods— retrospective prospective data radiologically confirmed were collected 4 centers located Pakistan United Arab Emirates. demographic, clinical, radiological, outcome recorded analyzed. Primary was death or dependency (modified Rankin score...
Background and Purpose — We sought to compare the safety efficacy of direct urokinase thrombolysis with systemic heparin anticoagulation for superior sagittal sinus thrombosis (SSST). Methods At University at Buffalo (NY) Texas (Dallas, Houston), we reviewed 40 consecutive patients SSST, treated local (thrombolysis group) or (heparin group). The group (n=20) received into SSS followed by anticoagulation. only. Neurological dysfunction was rated as follows: 0, normal; 1, mild (but able...
ABSTRACT Objective. The characteristics of intracranial tuberculoma on computed tomography (CT) and magnetic resonance imaging (MRI) are not well known. authors reviewed the features CT scans MRI. also correlated MRI various pulse sequences with neuropathological findings. Methods. charts patients were consecutively during period from 1988 to 1999. diagnosis was based pathology (n = 19), clinical or neuroimaging response tuberculous chemotherapy 57), evidence systemic tuberculosis (n=24)....
We analyzed the incidence, pattern and location of headache in consecutive 200 patients with proven diagnosis CVT to identify an association between localization site sinus involvement. Headache was present 136 (68%) patients. The duration (reported 128 patients) reported as acute (1-3 days), 81 (60%); sub-acute (4-14 33 (24%); chronic (more than 14 (10%). quality 72 throbbing 12 (9%), band like 27 (20%), thunderclap 7 (5%), other (pounding, exploding, stabbing, etc.) 26 (20%). 101...
<h3>Background</h3> Tuberculoma and cerebral infarctions are serious complications of central nervous system (CNS) tuberculosis. However, there no studies comparing prognostic value tuberculoma infarcts alone in patients diagnosed with CNS <h3>Objective</h3> The objective this study was to identify frequency a large sample tuberculosis patients. <h3>Methods</h3> Retrospective chart review tertiary care hospital Pakistan over 10-year period carried out. <h3>Results</h3> There were 404...
Background/Objective: Recent literature has identified links between vitamin B12 deficiency and depression.We compared the clinical response of SSRI-monotherapy with that B12-augmentation in a sample depressed patients low normal levels who responded inadequately to first trial SSRIs. Methods: Patients depression were randomized control arm (antidepressant only) or treatment (antidepressants injectable supplementation). Results: A total 199 screened. Out 73 34 (47%) group while 39 (53%) arm....
Background and Purpose- Cerebral infarctions complicate a variable proportion of tuberculous meningitis (TBM) cases adversely affect outcomes. The objective this study was to evaluate the predictors cerebral infarcts in patients with TBM assess their impact on mortality. Methods- based retrospective chart review all admitted tertiary care hospital between 2002 2013. Data were collected basic demographics, conventional vascular risk factors, radiological findings, severity TBM, neurological...
Early and accurate diagnosis of cerebral venous thrombosis (CVT) is possible with the help computed tomography (CT) scan magnetic resonance imaging (MRI). Empty Δ sign on postcontrast CT present in only up to 30% cases. The role venography not yet established, but it emerging as an effective modality for CVT. T2* MRI sequence superior spin echo detecting CVT small hemor rhages. MR considered technique choice follow-up CVT, certain cases, could be shows thrombus itself just absence signal...
ABSTRACT BACKGROUND AND PURPOSE There is a paucity of literature related to the neuroimaging CNS tuberculosis (TB) and largely covers pediatric TB. The objective this study was determine frequency different forms TB its associated complications longitudinal disease course using computed tomography (CT) MRI. METHODS Retrospective chart imaging review patients diagnosed with in tertiary care hospital Pakistan over 10‐year period. A total 452 initial brain MRI 209 CT scans were reviewed by an...