A5030328002- Primary Care and Health Outcomes
- Chronic Myeloid Leukemia Treatments
- Medical Coding and Health Information
- Chronic Lymphocytic Leukemia Research
- Health Promotion and Cardiovascular Prevention
- Blood Pressure and Hypertension Studies
- Urticaria and Related Conditions
- Monoclonal and Polyclonal Antibodies Research
- Clinical practice guidelines implementation
- Electronic Health Records Systems
- Antioxidant Activity and Oxidative Stress
- Healthcare Systems and Technology
- Rheumatoid Arthritis Research and Therapies
- Health Systems, Economic Evaluations, Quality of Life
- Obesity and Health Practices
- Pharmaceutical Practices and Patient Outcomes
- Sleep and related disorders
- Colorectal Cancer Screening and Detection
- Interprofessional Education and Collaboration
- Vaccine Coverage and Hesitancy
- Polymer crystallization and properties
- Eosinophilic Disorders and Syndromes
- Garlic and Onion Studies
- Health Sciences Research and Education
- Hernia repair and management
The University of Adelaide
2015-2024
Heidelberg University
2007-2024
University Hospital Heidelberg
2007-2024
Central Institute of Mental Health
2024
SA Health
2019-2023
Flinders University
2021-2023
Australasian Sleep Association
2023
Adelaide Institute for Sleep Health
2021-2023
Health Net
2023
Cancer Research UK
2023
We developed and used real-time RT-PCR assays to investigate how the expression of typical osteoblast-related genes by human bone marrow stromal cells (BMSC) is regulated (i) culture time in medium inducing osteogenic differentiation (ii) previous expansion enhancing cell commitment. BMSC from six healthy donors were expanded without (CTR) or with fibroblast growth factor-2 dexamethasone (FGF/Dex; these factors are known increase commitment) further cultivated for up 20 days ascorbic acid,...
Hypertension affects about 30% of adults worldwide. Garlic has blood pressure-lowering properties and the mechanism action is biologically plausible. Our trial assessed effect, dose–response, tolerability acceptability different doses aged garlic extract as an adjunct treatment to existing antihypertensive medication in patients with uncontrolled hypertension. A total 79 general practice systolic hypertension participated a double-blind randomised placebo-controlled dose–response 12 weeks....
Structured hydrogels showing form stability and elastic properties individually tailorable on different length scales are accessible in a one-step process. They support cell adhesion differentiation display growing pore size during degradation. In vivo experiments demonstrate their efficacy biomaterial-induced bone regeneration, not requiring addition of cells or growth factors.
Hot days are increasingly common and often associated with increased morbidity mortality, especially in the elderly. Most heat-related illness deaths preventable.Medicines may accentuate risk of dehydration illness, elderly people taking multiple medicines, through following mechanisms: diuresis electrolyte imbalance, sedation cognitive impairment, changed thermoregulation, reduced thirst recognition, sweat production, hypotension cardiac output.Commonly used medicines that significantly...
Abstract In the present study, we investigated role of phytoestrogen genistein and 17β-estradiol in human bone marrow stromal cells, undergoing induced osteogenic or adipogenic differentiation. Profiling estrogen receptors (ERs)-α, -β1, -β2, -β3, -β4, -β5, aromatase mRNAs revealed lineage-dependent expression patterns. During differentiation, osteoblast-determining core binding factor-α1 showed a progressive increase, whereas regulator peroxisome proliferator-activated receptor γ (PPARγ) was...
Flavanol-rich chocolate and lycopene-rich tomato extract have attracted interest as potential alternative treatment options for hypertension, a known risk factor cardiovascular morbidity mortality. Treatment of prehypertension (SBP 120–139/DBP 80–89 mmHg) may forestall progression to hypertension. However, there has been only limited research into non-pharmacological prehypertension. We investigated the effect dark or on blood pressure, their acceptability an ongoing option in...
Abstract Background Chronic insomnia is a highly prevalent disorder, with ten to thirty percent of Australian adults reporting chronic difficulties falling asleep and/or staying such that it causes significant daytime impairment. Current general practice guidelines recommend cognitive behavioural therapy for (CBTi) as first line treatment insomnia, however research suggests most consultations result in prescription hypnotic or sedative medicines. Although the point contact patients...
Twenty-nine synovial fluids from patients with rheumatoid arthritis (RA) and 10 other joint diseases were investigated regard to the presence of antibodies denatured human collagen collagen-anticollagen immune complexes. 12 29 RA showed anticollagen titres 1:16 1:512 in passive haemagglutination. Only one patient group no had a significant titre 1:32. Digestion bacterial collagenase resulted an increase two four dilution steps 9 fluids, while 6 previously negative 1:32 1:28 after digestion...
To evaluate a multifaceted intervention on diet, physical activity and health literacy of overweight obese patients attending primary care.A pragmatic two-arm cluster randomised controlled trial.Urban general practices in lower socioeconomic areas Sydney Adelaide.We aimed to recruit 800 each arm. Baseline assessment was completed by 215 (120 95 control).A practice nurse-led preventive check, mobile application telephone coaching.Primary outcomes were measured at baseline, 6 12 months,...
In Australia, pneumococcal vaccine is provided free to all adults aged ≥65 years and Indigenous people 15–65 years, subsidized for non-Indigenous <65 of age with risk factors. This study aimed explore vaccination uptake in older patients attending 550 Australian general practices from 2010–2017 by patient sociodemographics, presence comorbidities practice characteristics. Study 1: a cross-sectional analysis 'active' each year was performed calculate annual uptake. 2: cohort 58,589 'every...
Influenza vaccination is recommended for Australians 18+ years old with medical risk factors, but coverage suboptimal. We aimed to examine whether automatic, opportunistic patient reminders (SMS and/or printed) before appointments a general practitioner increased influenza uptake. This clustered non-randomised feasibility study in Australian practice included patients aged 18–64 at least one factor attending participating practices between May and September 2021. Software installed...
This paper presents two approaches for the problem of multiple target tracking (MTT) and specifically people tracking. Both filters are based on sequential Monte Carlo methods (SMCM) joint probability data association (JPDA). The have been implemented tested real from a laser measurement system. Experiments show that both able to track moving persons. A comparison is given advantages disadvantages presented.
Abstract Background Colorectal cancer (CRC) is rising in incidence young adults, and this observation currently unexplained. We investigated whether having a personal history of type 2 diabetes mellitus (T2D) was potential risk factor for young‐onset colorectal (YOCRC). Methods The South Australian Young Onset (SAYO) CRC study series adults with below age 55. Ninety unrelated YOCRC cases were recruited to the study. Personal detailed family T2D obtained at face‐to‐face interview confirmed...
Clonal cytogenetic aberrations of the Philadelphia chromosome (Ph) positive hematopoiesis have been associated with natural evolution chronic myeloid leukemia (CML) to advanced disease. Ph negative metaphases described after treatment interferon or imatinib. This study evaluates effect dasatinib on clones additional and frequency novel in metaphases. Seventy-one patients treated imatinib failure for a median nine months were evaluated. Novel within appeared six three patients, respectively.
Dasatinib is a multitargeted inhibitor of ABL, the SRC family, and other tyrosine kinases. We sought to evaluate effects this drug on cell proliferation, centrosomes, mitotic spindles, cycle progression in vitro vivo.Human dermal fibroblasts, Chinese hamster cells, human osteosarcoma blood bone marrow mononuclear cells from 32 patients with chronic myeloid leukemia, gastrointestinal stromal tumor, systemic mastocytosis as well six healthy individuals were investigated. The dasatinib compared...