A5064187028- Breast Lesions and Carcinomas
- Breast Cancer Treatment Studies
- Breast Implant and Reconstruction
- Cancer and Skin Lesions
- Viral-associated cancers and disorders
- Lymphoma Diagnosis and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer Cells and Metastasis
- Vascular Tumors and Angiosarcomas
- AI in cancer detection
- Reconstructive Surgery and Microvascular Techniques
- HER2/EGFR in Cancer Research
- Global Cancer Incidence and Screening
- Cancer Genomics and Diagnostics
- Eosinophilic Disorders and Syndromes
- BRCA gene mutations in cancer
- Genetic Associations and Epidemiology
- Cardiac tumors and thrombi
- Sarcoma Diagnosis and Treatment
- Body Image and Dysmorphia Studies
- Male Breast Health Studies
- PI3K/AKT/mTOR signaling in cancer
- Multiple and Secondary Primary Cancers
- Cancer Risks and Factors
- Digital Imaging in Medicine
National Cancer Centre Singapore
2012-2022
SingHealth Duke-NUS Academic Medical Centre
2015-2022
Singapore General Hospital
2006-2022
Mount Elizabeth Novena Hospital
2019
National University of Singapore
2018
SingHealth
2018
Gleneagles Hospital
2018
National Cancer Centre Japan
2015
National University Hospital
2009
Cell state transitions control the functional behavior of cancer cells. Epithelial-to-mesenchymal transition (EMT) confers stem cell-like properties, enhanced tumorigenicity and drug resistance to tumor cells, while mesenchymal-epithelial (MET) reverses these phenotypes. Using high-throughput chemical library screens, retinoids are found be potent promoters MET that inhibit in basal-like breast cancer. defined by reprogramming lipid metabolism. Retinoids bind cognate nuclear receptors, which...
Background and objective Intraoperative frozen section of the sentinel lymph node (SLN) in clinically negative breast cancer patients detects metastatic disease enables axillary dissection to be performed same operative setting. Internationally, false rate (FNR) for SLN biopsy ranges from 5.5% 43%. The size metastasis has been identified as a key factor affecting FNR. We review our institutional experience on accuracy intraoperative biopsy. Methods Data were collected retrospectively...
Fibroepithelial lesions (FELs) are a heterogeneous group of tumours comprising fibroadenomas (FAs) and phyllodes (PTs). Here we used 16-gene panel that was previously discovered to be implicated in pathogenesis progression, characterise large international cohort FELs via targeted sequencing. The study comprised 303 (38%) FAs 493 (62%) PTs which were contributed by the International Consortium. There 659 (83%) Asian 109 (14%) non-Asian FELs, while ethnicity rest unknown. Genetic aberrations...
EBV-positive smooth muscle tumor (EBV+SMT) is a rare disease with no established therapy. We describe the largest single institution analysis in renal transplant recipients. It aims to define its clinical features and determine expression of EBV latent genes as well key molecular pathways.Patients EBV+SMT were identified from Singapore General Hospital Renal Transplant Registry database. These tumors investigated for Southern blots, antigens, mammalian target rapamycin (mTOR), Akt, p70 S6...
// Claire Hian Tzer Chan 1, * , Prabhakaran Munusamy Sau Yeen Loke 1 Geok Ling Koh Audrey Zhi Yi Yang Hai Law 2 Chui Sheun Yoon Chow Yin Wong 3 Wei Sean Yong 4 Nan Soon 5, 6 Raymond Chee Hui Ng 5 Kong Wee Ong Preetha Madhukumar Chung Lie Oey Gay Ho 4, 7 Puay Hoon Tan 8 Min Han 9, 10 Peter Ang Sim Yap and Ann Siew Gek Lee 11, 12 Division of Medical Sciences, Humphrey Oei Institute Cancer Research, National Centre, Singapore DNA Diagnostic Research Laboratory, KK Women's Children's Hospital,...
Abstract Background Known collectively as breast fibroepithelial lesions (FELs), the common fibroadenomas (FAs) and rarer phyllodes tumors (PTs) are a heterogenous group of biphasic neoplasms. Owing to limited tissue availability, inter-observer variability, overlapping histological features heterogeneity these lesions, diagnosing them accurately on core biopsies is challenging. As choice management option depends diagnosis; novel 16-gene panel assay was developed improve accuracy...
Aim To identify important clinicopathological parameters that are most helpful in predicting additional non-sentinel lymph node (SLN) metastasis among patients with a positive SLN biopsy the Singapore breast cancer population. Methods A total of 1409 who underwent were reviewed over 5 year period from July 2004 to October 2009. General Hospital (SGH) nomogram was developed predictors Memorial Sloan-Kettering Cancer Centre (MSKCC) using 266 primary invasive and subsequently had an axillary...
We performed a retrospective review to determine the prognostic significance of isolated tumour cells (ITCs) and micrometastases sentinel lymph nodes patients with breast cancer.A total 1044 diagnosis invasive carcinoma who underwent surgical treatment including node biopsy procedure from July 2004 October 2009 were included in study.In 710 (68%) patients, no metastasis was seen nodes. ITCs detected 22 (2.1%) micrometastasis 52 (5.0%) macrometastases 260 (24.9%). With median follow-up 28.8...
Nipple-sparing mastectomies (NSMs) are increasingly performed to obtain the best aesthetic and psychological outcomes in breast cancer treatment. However, merely preserving nipple-areolar complex (NAC) does not guarantee a good outcome. Darkly pigmented NACs tendency for poor scarring particular challenges when treating Asian patients. Herein, we review reconstructive following NSM at Singapore General Hospital.All breasts reconstructed over an 11-year period from 2005 2015 were reviewed....
Contralateral prophylactic mastectomy (CPM) removes the non-diseased breast in women who have unilateral cancer. This reduces incidence of contralateral cancer, and potentially improves survival high risk patients. Such surgical risk-reduction strategy is increasingly being adopted United States, despite a decreasing The use CPM an Asian population yet unknown. We present first report on rates trends Singapore, country with highest cancer Asia.A retrospective review all patients had surgery...
Abstract We aim to identify clinicopathologic predictors for response neoadjuvant chemotherapy and evaluate the prognostic value of pathologic complete ( pCR ) on survival in Asia. This study included 915 breast cancer patients who underwent at five public hospitals Singapore Malaysia. following was defined as 1) no residual invasive tumor cells (ypT0/is) 2) axillary lymph nodes (ypT0/is ypN0). Association between characteristics treatment were evaluated using chi‐square test multivariable...
Malignant transformation of the epithelial component phyllodes tumours (PT) is rare and only reported in literature as sporadic cases carcinoma associated with PTs. We report clinicopathological characteristics situ invasive coexisting PT 10 patients treated our institution over an 11-year period from 1992 to 2012. Ten or were identified records. Six had found within PT. All female a median age 47 (43-72) years. One patient history same breast while another well ductal contralateral breast....
Post-mastectomy breast reconstruction is an integral component of cancer treatment. It often perceived that women in Asian countries have a lower rate post-mastectomy than Western populations. This study describes trends timing and types performed the largest healthcare provider Singapore, over period 12 years. also reports on oncological outcomes surgical safety. A retrospective review all patients who underwent from January 2001 to December 2012 at National Cancer Centre Singapore General...
This study identified factors predicting malignant upgrade for atypical ductal hyperplasia (ADH) diagnosed on core-needle biopsy (CNB) and developed a nomogram to facilitate evidence-based decision making.This retrospective analysis included women with ADH at the National Cancer Centre Singapore (NCCS) in 2010-2015. Cox proportional hazards regression was used identify clinical, radiological, histological associated upgrade. A constructed using variables strongest associations multivariate...
Although mammography is the gold standard for breast cancer screening, high rates of false-positive mammograms remain a concern. Thus, there an unmet clinical need non-invasive and reliable test to differentiate between malignant benign lesions in order avoid subjecting patients with abnormal unnecessary follow-up diagnostic procedures. Serum samples from 116 64 were comprehensively profiled 2,083 microRNAs (miRNAs) using next-generation sequencing. Of 180 profiled, three outliers removed...
The advent of skin-sparing mastectomy has allowed for the reconstruction breast and nipple with improved cosmesis. However, nipple-areolar complex (NAC) in Asian patients is more pigmented scars easily. Therefore, commonly described incisions tend to result poor aesthetic outcomes cancer.We describe an algorithmic approach on basis location biopsy scar tumor site size. Four incision types are described: peri-areolar, a peri-areolar second distant skin paddle, "racquet handle," adjacent...