A5037508097- Autophagy in Disease and Therapy
- Breast Cancer Treatment Studies
- MRI in cancer diagnosis
- Advanced MRI Techniques and Applications
- Epigenetics and DNA Methylation
- Global Cancer Incidence and Screening
- Microtubule and mitosis dynamics
- Breast Lesions and Carcinomas
- Blind Source Separation Techniques
- AI in cancer detection
- Infectious Encephalopathies and Encephalitis
- Lung Cancer Diagnosis and Treatment
- Cervical and Thoracic Myelopathy
- Hepatocellular Carcinoma Treatment and Prognosis
- Fetal and Pediatric Neurological Disorders
- Medical Imaging Techniques and Applications
- Infectious Diseases and Tuberculosis
- Spinal Fractures and Fixation Techniques
- Celiac Disease Research and Management
- Erythrocyte Function and Pathophysiology
- Colorectal Cancer Screening and Detection
- Biomedical Research and Pathophysiology
- Gallbladder and Bile Duct Disorders
- Telomeres, Telomerase, and Senescence
- Otitis Media and Relapsing Polychondritis
National Cancer Centre Singapore
2007-2022
Singapore General Hospital
1999-2006
National Cancer Centre Japan
2003
Taipei Veterans General Hospital
1986
The most commonly utilized class of chemotherapeutic agents administered as a first-line therapy are antimitotic drugs; however, their clinical success is often impeded by chemoresistance and disease relapse. Hence, better understanding the cellular pathways underlying escape from cell death critical. Mitotic slippage describes process where cells exit drug-enforced mitotic arrest "slip" into interphase without proper chromosome segregation cytokinesis. current report explores fate...
Abstract: The first nation-wide mammographic screening program in Asia, BreastScreen Singapore (BSS), was launched January 2002. This study compared the presentation and results of screen-detected breast cancers with symptomatic two affiliated high-volume institutions, one which an assessment centre for BSS. medical records patients diagnosed primary cancer at Department General Surgery, Hospital Surgical Oncology, National Cancer Centre, Singapore, during period 2002 to December 2003 were...
This study identified factors predicting malignant upgrade for atypical ductal hyperplasia (ADH) diagnosed on core-needle biopsy (CNB) and developed a nomogram to facilitate evidence-based decision making.This retrospective analysis included women with ADH at the National Cancer Centre Singapore (NCCS) in 2010-2015. Cox proportional hazards regression was used identify clinical, radiological, histological associated upgrade. A constructed using variables strongest associations multivariate...
We have measured the temperature dependence calcium-induced fusion of sonicated phosphatidylserine vesicles. The vesicles were incubated in presence calcium at a specified until resulting aggregation or process had gone to completion. EDTA was then added and final size vesicle population by using dynamic light scattering. This plotted against incubation show fusion. curve has peak near 11 degrees C which may be associated with phase transition prior process.
We describe a 24-year old male patient with systemic lupus erythematosus (SLE) the gastrointestinal manifestations of protein-losing enteropathy (PLE) and primary sclerosing cholangitis (PSC). He presented periorbital, scrotal lower limb oedema. PLE was diagnosed because hypoalbuminaemia together an elevation alpha-1-antitrypsin stool clearance absence proteinuria. PSC on basis elevated serum alkaline phosphatase lymphocytic fibrous cholangitis. His disease also complicated by...
Two young men had similar nonobstructive idiopathic pachymeningitis cervicalis hypertrophica, causing chronic (13 and 11 years respectively) C8-T1 radiculomyelopathy proved by surgical pathological findings. The preoperative Queckenstedt tests myelography showed no evidence of CSF obstruction. These unusual findings contrast with previous reports which all described complete or at least partial, block. on metrizamide computed tomogram have not been before. In the two patients it revealed...
Mammography detected 34 (25%) cases of ductal carcinoma in situ (DCIS) the breast out a total 135 cancers diagnosed 28, 231 participating women during Singapore screening project. Radiologic findings these with DCIS were calcifications only 25 (74%); mass 2 (6%); and remaining 7 (20%) cases. Calcifications classified mammographically as powderish (6%), crushed stone-like 16 (50%) casting 14 (44%) Pathologic assessment revealed 11 (32%) pure comedo, (47%) mixed, 3 (9%) cribriform, (6%)...
Abstract Purpose To study the possibility of using independent component analysis (ICA) to identify breast lesions as separate hemodynamic sources on dynamic contrast‐enhanced (DCE) MR images, depicted by passage contrast medium. Materials and Methods Six patients who were histopathologically confirmed with carcinoma underwent DCE MRI 5 precontrast 60 postcontrast scans at a time‐resolution 8 s. A spatial ICA algorithm was applied data set extract maps corresponding source locations...
A distinct feature of the tumor vasculature is its tortuosity and irregular branching vessels, which can translate to a wider dispersion higher variability blood flow in tumor. To enable be assessed vivo by imaging, tracer kinetic model that accounts for developed use with dynamic contrast-enhanced (DCE) CT. The proposed adopts multiple-pathway approach allows quantification relative distribution, reflects vasculature. Monte Carlo simulation experiments were performed study possibility...
March 1999Cervical radiculopathy due to epidural varicose veins.Authors: P H Lai, J T Ho, S Wang, and B PanAuthor Info & AffiliationsVolume 172, Issue 3https://doi.org/10.2214/ajr.172.3.10063901 METRICS otherformats
<div>Abstract<p>The most commonly utilized class of chemotherapeutic agents administered as a first-line therapy are antimitotic drugs; however, their clinical success is often impeded by chemoresistance and disease relapse. Hence, better understanding the cellular pathways underlying escape from cell death critical. Mitotic slippage describes process where cells exit drug-enforced mitotic arrest “slip” into interphase without proper chromosome segregation cytokinesis. The...
<div>Abstract<p>The most commonly utilized class of chemotherapeutic agents administered as a first-line therapy are antimitotic drugs; however, their clinical success is often impeded by chemoresistance and disease relapse. Hence, better understanding the cellular pathways underlying escape from cell death critical. Mitotic slippage describes process where cells exit drug-enforced mitotic arrest “slip” into interphase without proper chromosome segregation cytokinesis. The...
Introduction: We compare the breath-hold fast recovery spin echo (BHFRFSE) T2-weighted and non-breath-hold (NBHFSE) sequences in image quality lesion characterisation of focal liver lesions. Materials Methods: Fat-suppressed magnetic resonance (MR) images obtained with 2 (BHFRFSE NBHFSE) 79 patients 113 lesions were analysed retrospectively. The nature evaluated by experienced radiologists. Results: Based on receiver operating characteristic curve analysis, was comparable for both sequences....