A5058827476- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- RNA modifications and cancer
- Cancer-related Molecular Pathways
- Tracheal and airway disorders
- Wnt/β-catenin signaling in development and cancer
- Head and Neck Cancer Studies
- Colorectal Cancer Treatments and Studies
- Lung Cancer Research Studies
- Cell Adhesion Molecules Research
- Cancer-related gene regulation
- RNA Interference and Gene Delivery
- Peptidase Inhibition and Analysis
- Medical Imaging and Pathology Studies
- Vascular Anomalies and Treatments
- Cancer, Hypoxia, and Metabolism
- Angiogenesis and VEGF in Cancer
- Head and Neck Surgical Oncology
- Pleural and Pulmonary Diseases
- Occupational and environmental lung diseases
- Cancer Cells and Metastasis
- Pulmonary Hypertension Research and Treatments
- Cancer Genomics and Diagnostics
- Cancer Research and Treatments
- Pancreatic and Hepatic Oncology Research
Sun Yat-sen University Cancer Center
2019-2025
Sun Yat-sen University
2019-2025
Chinese Academy of Sciences
2024
Kitano Hospital
1997-2023
Kyoto University
2011-2019
Japan Breast Cancer Research Group
2015
Kagawa University
2002-2011
Kyoto University Hospital
2011
Kindai University
1997
Tenri Hospital
1995
Abstract Background Nearly 90% locoregionally advanced nasopharyngeal carcinoma (LANPC) responds to induction chemotherapy (IC) with significant tumor volume shrinkage. Radiotherapy always follows IC, and reduced has been proposed. However, the efficacy safety of reduced‐volume radiotherapy is uncertain. Methods In this multi‐center, noninferiority, randomized, controlled trial, patients LANPC who completed IC were randomly assigned (1:1) receive based on post‐IC (Post‐IC group) or...
To evaluate whether angiogenic factors are of clinical relevance to actual human pancreatic cancers, we studied the intratumoral microvessel density (IMD), and PD-ECGF, VEGF protein expression in 40 cancers using immunohistochemistry. We also investigated PD-ECGF gene reverse transcriptase-PCR (RT-PCR). Of studied, 30 carcinomas (75.0%) were evaluated be PD-ECGF-positive 10 (25.0%) determined PD-ECGF-negative. In contrast, 27 (67.5%) VEGF-positive, whereas 13 (32.5%) VEGF-negative. was...
The Wnt gene family encodes the multifunctional signaling glycoproteins. We performed present study to investigate clinical significance of Wnt5a expression in non-small-cell lung cancer (NSCLC).One hundred twenty-three patients with NSCLC who had undergone resection were investigated. Real-time quantitative reverse transcriptase polymerase chain reaction was evaluate expression. Immunohistochemistry protein expression, Ki-67 proliferation index, tumor angiogenesis, and beta-catenin vascular...
JCO
Importance Approximately 20% to 30% of patients with locoregionally advanced nasopharyngeal carcinoma (NPC) experience disease relapse despite definitive chemoradiotherapy. The programmed cell death 1 (PD-1) blockade camrelizumab has demonstrated considerable value in recurrent or metastatic NPC, while its role NPC is unclear. Objective To evaluate the efficacy and safety adjuvant for NPC. Design, Setting, Participants Randomized, open-label, multicenter, phase 3 clinical trial conducted...
Immunohistochemical analyses of the effects hepatocyte growth factor (HGF) and c-Met expression on tumour angiogenesis were performed 88 patients with non-small-cell lung cancers (NSCLCs). In all, 22 carcinomas (25.0%) intratumoral HGF-positive, 14 (15.9%) stromal 36 (40.9%) c-Met-positive. None Examination revealed that frequency tumours a high Ki-67 index was significantly greater for HGF-positive than HGF-negative (P=0.0197). The also c-Met-positive c-Met-negative (P=0.0301). However,...
We investigated the clinical significance of E2F1 gene expression in relation to its target genes, thymidylate synthase (TS) and Survivin, case non-small-cell lung cancer (NSCLC).One hundred twenty-seven cases resected NSCLC were analyzed. Quantitative reverse transcription-PCR was done evaluate E2F1, TS, Survivin. Immunohistochemistry investigate protein The Ki-67 proliferation index apoptotic using terminal deoxyribonucleotidyl transferase-mediated dUTP nick-end labeling method also...
Angiogenesis has important effects on tumor growth and metastasis. It is regulated by a variety of angiogenic angiostatic factors.To evaluate the cell-derived factors, we performed an immunohistochemic study to intratumoral expression vascular endothelial factor (VEGF) interleukin-8 (IL-8) in relation microvessel density (IMD) tumors from 104 nonsmall cell lung carcinoma (NSCLC)patients.Fifty-four carcinomas were VEGF-positive, 47 IL-8-positive, 53 hypervascular tumors. There was no...
Several members of the transmembrane 4 superfamily (TM4SF) have been reported to be related tumor progression and metastasis. The aims our study were clarify relationship between TM4SF pancreatic cancer determine prognostic significance in human cancer. mRNA levels for MRP-1/CD9, KAI1/CD82 ME491/CD63, which belong gene family, evaluated 40 resectable adenocarcinomas using reverse transcriptase-PCR. MRP-1/CD9 expression was associated with lymph node status, pathological status. Moreover,...
We performed a clinical study to identify biological markers useful for the treatment of resectable non-small-cell lung cancers (NSCLCs). In all, 173 patients were studied. By immunohistochemistry, we evaluated Ki-67 proliferation index, tumour vascularity, thymidylate synthase (TS), vascular endothelial growth factor (VEGF)-A, VEGF-C, and E (epithelial)-cadherin. Concerning survival NSCLC patients, vascularity (P<0.01), VEGF-A status (P=0.03), VEGF-C E-cadherin (P=0.03) significant...
PURPOSE The transmembrane-4 superfamily (TM4SF) is a recently discovered family of genes. Of the TM4SF members, MRP-1/CD9, KAI1/CD82, and ME491/CD63 have been reported to modulate tumor progression or metastasis. In this study, we investigated relationships between these three genes, MRP-1, KAI1, ME491, in patients with non-small-cell lung cancers (NSCLCs). Moreover, assessed prognostic value evaluating expressions ME491 simultaneously NSCLCs. PATIENTS AND METHODS One hundred seventy-two up...
The sensitivity to 5-fluorouracil (5-FU) has been reported be associated with target molecule thymidylate synthase (TS), fluoropyrimidine-metabolising enzymes such as orotate phosphoribosyltransferase (OPRT), and dihydropyrimidine dehydrogenase (DPD). We performed an immunohistochemical study on the clinical significance of TS, OPRT, DPD expression using 151 resected non-small-cell lung cancer (NSCLC) patients postoperatively treated a combination tegafur uracil (UFT). Eighty-two carcinomas...
Motility-related protein-1 (MRP-1)/CD9 is a trans-membrane glycoprotein closely associated with suppression of cell motility and reduced metastatic potential some tumor cells. We currently report that, according to the RT-PCR method for MRP-1/CD9 gene expression, patients low expression in non-small-cell lung cancer, especially adenocarcinoma type, showed short overall survival. Then, determine accurately prognostic value product levels lung-adenocarcinoma cells, we immunohistochemically...
Abstract Background To identify thyroid dose‐volume thresholds for radiotherapy (RT)‐related hypothyroidism (HT) in patients with nasopharyngeal carcinoma (NPC) treated intensity‐modulated RT (IMRT). In this way, we desired to guide the design of treatment plans and, finally, lower HT prevalence. Methods total, 345 NPC IMRT were evaluated retrospectively during a median follow‐up 45.2 (range, 11.3‐64.9) months. Serum‐based assessments function before and after monitored periodically. Thyroid...