A5010124011- Hematopoietic Stem Cell Transplantation
- Cancer therapeutics and mechanisms
- Acute Myeloid Leukemia Research
- Neutropenia and Cancer Infections
- Cyclopropane Reaction Mechanisms
- Glycosylation and Glycoproteins Research
- Fluorine in Organic Chemistry
- Lung Cancer Research Studies
- Proteoglycans and glycosaminoglycans research
- Acute Lymphoblastic Leukemia research
- Immune Cell Function and Interaction
- Lung Cancer Treatments and Mutations
- Renal Transplantation Outcomes and Treatments
- Congenital Heart Disease Studies
- Phytochemistry and Biological Activities
- Influenza Virus Research Studies
- Bioactive Compounds and Antitumor Agents
- Organ Transplantation Techniques and Outcomes
- Renal Diseases and Glomerulopathies
- Enzyme Production and Characterization
- Cancer, Hypoxia, and Metabolism
- T-cell and B-cell Immunology
- RNA Interference and Gene Delivery
- Organophosphorus compounds synthesis
- Mycobacterium research and diagnosis
Takeda (Japan)
2025
Aichi University of Education
2007-2024
Jichi Medical University
2014-2023
Prism Biolab Corporation (Japan)
2017-2022
Jichi Medical University Hospital
2020
Ureshino Medical Center
2012-2019
Tokyo Institute of Technology
1997-2018
Life Science Institute
2017-2018
Jichi Medical University Saitama Medical Center
2014-2017
Kitasato Institute Hospital
2017
To evaluate whether angiogenic factors are of clinical relevance to actual human pancreatic cancers, we studied the intratumoral microvessel density (IMD), and PD-ECGF, VEGF protein expression in 40 cancers using immunohistochemistry. We also investigated PD-ECGF gene reverse transcriptase-PCR (RT-PCR). Of studied, 30 carcinomas (75.0%) were evaluated be PD-ECGF-positive 10 (25.0%) determined PD-ECGF-negative. In contrast, 27 (67.5%) VEGF-positive, whereas 13 (32.5%) VEGF-negative. was...
A microbial screen using a yeast strain with conditional deficiency in the GPA1 gene was carried out to search for inhibitors of protein farnesyltransferase (PFT). Streptomyces found produce active compounds named UCF1-A, UCF1-B, and UCF1-C. Structural determination these revealed that UCF1-C is identical known antibiotic, manumycin, whereas UCF1-A UCF1-B are structurally related manumycin. All three UCF1 suppress lethality gpa1 disruption, exhibiting strongest activity. inhibits as well rat...
Saintopin is an antitumor antibiotic recently discovered in mechanistically oriented screening using purified calf thymus DNA topoisomerases. induced topoisomerase I mediated cleavage comparable to that of camptothecin, and II equipotent those 4'-(9-acridinylamino)methanesulfon-m-anisidide (m-AMSA) or 4'-demethylepipodophyllotoxin 9-(4,6-O-ethylidene-beta-D-glucopyranoside) (VP-16). Treatment a reaction mixture containing saintopin with either elevated temperature (65 degrees C) higher salt...
Abstract Background Bloodstream infections ( BSI ) are frequently observed after allogeneic hematopoietic stem cell transplant HSCT ), and could cause morbidity mortality. Methods We retrospectively evaluated the incidence, characteristics of, risk factors for at both pre‐ post‐engraftment in 209 adult patients our institute between June 2006 December 2013. The median age transplantation was 45 years (range, 15–65). A total of 122 received bone marrow, 68 peripheral blood cells, 19 umbilical...
A new γ-lactone derivative named davallialactone (4) and the 7-O-β-D-glucuronide of (±)-eriodictyol (5a) have been isolated from Davallia mariesii MOORE along with caffeic acid (1), 4-O-β-D-glucopyranosylcaffeic (2) 4-O-β-D-glucopyranosyl-p-coumaric (3). The structures compounds were determined by chemical spectroscopic methods including two-dimensional nuclear magnetic resonance (2D NMR) techniques, especially 1H-detected heteronuclear multiple-bond multiple-quantum coherence long-range C-H...
Abstract Background Inflammatory bowel disease (IBD) is a major cause of short syndrome (SBS). Patients with SBS face numerous challenges throughout their lives, leading to reduced quality life (QoL). Addressing unmet needs (UMNs) improve QoL critical; however, research on the UMNs patients remains limited. This study aimed identify IBD (SBS-IBD) and without (SBS-non-IBD) clarify how these affect QoL. Methods A survey patients’ was conducted between February May 2024 in Japan, involving...
A water extract of Coptis chinensis was found to have the ability stabilize cleavable complex with mammalian DNA topoisomerase I. As result bioassay-guided fractionation, two protoberberine alkaloids, epiberberine and groenlandicine, were identified as active principles I-mediated cleavage activity in vitro. These alkaloids did not induce II-mediated cleavage. During further examination structurally related berberrubine which is produced during processing rhizome traditional medicine, a...
Oligo(Leu)s containing Pro or (Dmob) Leu residues were prepared by the stepwise elongation and fragment condensation methods. The peptides following: Boc‐Leu n ‐OBzl (n = 3–6 9), Boc‐Pro‐Leu 3 ‐OBzl, ‐Pro‐OBzl 3–5), ‐Pro‐Leu 4), Boc‐(Leu 4 ‐Pro) 2 6 7), ‐Gly‐(Dmob) Leu‐OMe, Boc‐[Leu Leu‐Leu ] 1 2). insertion of Gly‐(Dmob) into a peptide chain caused “the segment separation” achieved remarkable solubility improvement N ‐ C ‐protected oligo(Leu) derivatives in variety organic solvents....
Iron supplementation is a mainstay for management of renal anaemia in patients receiving haemodialysis (HD). Although it well known that single intravenous iron (IVIR) administration transiently enhances oxidative stress HD patients, the consequence repeated IVIR still unknown. This study aims to clarify time course changes serum 8-hydroxy-2'-deoxyguanosine (8-OHdG), marker DNA injury, during period patients.Twenty-seven (62+/-14 years and 23 males) on long-term participated this study. All...
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