A5089194366- Hematopoietic Stem Cell Transplantation
- Lymphoma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Immune Cell Function and Interaction
- Chronic Lymphocytic Leukemia Research
- Mesenchymal stem cell research
- CNS Lymphoma Diagnosis and Treatment
- Multiple Myeloma Research and Treatments
- Acute Lymphoblastic Leukemia research
- Chronic Myeloid Leukemia Treatments
- Neutropenia and Cancer Infections
- Immunotherapy and Immune Responses
- Viral-associated cancers and disorders
- T-cell and B-cell Immunology
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Hematological disorders and diagnostics
- Eosinophilic Disorders and Syndromes
- CAR-T cell therapy research
- Helicobacter pylori-related gastroenterology studies
- Childhood Cancer Survivors' Quality of Life
- Genomics, phytochemicals, and oxidative stress
- Immune Response and Inflammation
- Renal Transplantation Outcomes and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Platelet Disorders and Treatments
Jichi Medical University
2016-2025
Jichi Medical University Hospital
2010-2020
University of Aberdeen
2019
University of St Andrews
2019
National Library of Scotland
2019
National Heart Lung and Blood Institute
2011-2015
National Institutes of Health
2011-2015
Hospital General Universitario Morales Meseguer
2011
Asahikawa Medical University
2011
Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo
2011
In vivo cell tracking by MRI can provide means to observe biological processes and monitor therapy directly. Immune cells, e.g., macrophages, play crucial roles in many pathophysiological processes, including organ rejection, inflammation, autoimmune diseases, cancer, atherosclerotic plaque formation, numerous neurological disorders, etc. The current gold standard for diagnosing staging rejection after transplantation is biopsy, which not only invasive, but also prone sampling errors. Here,...
Extranodal involvement is considered a poor prognostic factor for patients with diffuse large B-cell lymphoma (DLBCL); however, the impact of specific sites has not been fully elucidated.The authors retrospectively analyzed 1221 treated uniformly standard R-CHOP therapy between 2003 and 2006. Patients distinct forms DLBCL such as intravascular lymphoma, primary effusion pyothorax-associated central nervous system intraocular were also excluded. The evaluated 26 extranodal respect to impact....
Central nervous system (CNS) events, including CNS relapse and progression to CNS, are known be serious complications in the clinical course of patients with lymphoma. This study aimed evaluate risk events diffuse large B-cell lymphoma rituximab era. We performed a retrospective survey Japanese diagnosed who underwent primary therapy R-CHOP chemoimmunotherapy between September 2003 December 2006. Patients had received any prophylactic treatment were excluded. Clinical data from 1221...
We recently reported that rabbit antithymocyte globulin was markedly inferior to horse as a primary treatment for severe aplastic anemia. Here we expand on our findings in this unique cohort of patients. Rabbit detectable plasma longer periods than globulin; retained functional capacity bind lymphocytes up 1 month, only about 2 weeks. In the first week after there were much lower numbers neutrophils patients treated with receiving globulin. Both globulins induced "cytokine storm" days...
ABSTRACT Recent evidence indicates that the TCA cycle metabolite fumarate plays a specific role in modulating signaling pathways immune cells. We have previously shown dimethyl (DMF) reduces glutathione (GSH) activity and causes accumulation of cellular reactive oxygen species (ROS), thereby compromising effector responses metabolic activities activated T‐cells. However, precise mechanism by which DMF modulates T‐cell remains to be elucidated. This study demonstrates inhibits proliferation,...
Influenza virus infections (IVIs) are an important cause of complications and death in immunocompromised patients, but the incidence risk factors for IVIs hematological diseases including benign not fully understood. We retrospectively investigated patients with who visited our hematology outpatient department between 2012 2019. In 4,864 outpatients, 81(1.67%) were identified. The was 4.82 (95% confidence interval [CI], 3.85-5.96) per 1,000 person-years, significantly higher rates...
In the rituximab era, several large studies have suggested that full-dose plus cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP) might be best treatment for patients with diffuse B-cell lymphoma (DLBCL) aged 60 years older. However, it remains unclear whether this is also case those 70 Previously untreated DLBCL older (elderly) were treated R-70%CHOP, younger than (younger) R-CHOP every 3 weeks, a total of 6-8 cycles. Complete remission (CR) rates in elderly versus 75 vs....
Xenogeneic graft-versus-host disease (GVHD) models in highly immunodeficient mice are currently being used worldwide to investigate human immune responses against foreign antigens vivo. However, the individual roles of CD4+ and CD8+ T cells, donor/host hematopoietic nonhematopoietic antigen-presenting cells (APCs) induction development GVHD have not been fully investigated. In present study, we comprehensively investigated antigen presentation capacity APCs xenogeneic using nonobese...