A5007489933- Head and Neck Cancer Studies
- Head and Neck Surgical Oncology
- Lung Cancer Research Studies
- Lung Cancer Treatments and Mutations
- RNA modifications and cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer, Hypoxia, and Metabolism
- Ubiquitin and proteasome pathways
- Salivary Gland Tumors Diagnosis and Treatment
- Ear and Head Tumors
- Lung Cancer Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Cancer, Lipids, and Metabolism
- Viral-associated cancers and disorders
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Cancer Diagnosis and Treatment
- Immune Cell Function and Interaction
- Radiomics and Machine Learning in Medical Imaging
- Cancer Immunotherapy and Biomarkers
- Multi-Criteria Decision Making
- Infectious Diseases and Mycology
- Esophageal Cancer Research and Treatment
- Oral health in cancer treatment
- DNA Repair Mechanisms
Sun Yat-sen University Cancer Center
2016-2025
Sun Yat-sen University
2016-2025
State Key Laboratory of Oncology in South China
2013-2025
South China Normal University
2025
Key Laboratory of Guangdong Province
2006-2022
South China Institute of Collaborative Innovation
2017
Chongqing University
2016
Dalian Medical University
2013
Southern Medical University
2010
Platinum-based concurrent chemoradiotherapy is the standard of care for patients with locoregionally advanced nasopharyngeal carcinoma. Additional gemcitabine and cisplatin induction chemotherapy has shown promising efficacy in phase 2 trials.
To report long‐term results of a randomized controlled trial that compared cisplatin/fluorouracil/docetaxel (TPF) induction chemotherapy (IC) plus concurrent chemoradiotherapy (CCRT) with CCRT alone in locoregionally advanced nasopharyngeal carcinoma (NPC). Patients stage III–IVB (except T3–4 N0) NPC were randomly assigned to receive IC (n = 241) or 239). included three cycles docetaxel (60 mg/m 2 d1), cisplatin and fluorouracil (600 /d civ d1–5) every 3 weeks. from both groups received...
Abstract Programmed cell death protein-1 (PD-1)/programmed ligand-1 (PD-L1) interaction plays a crucial role in tumor-associated immune escape. Here, we verify that triple-negative breast cancer (TNBC) has higher PD-L1 expression than other subtypes. We then discover nucleophosmin (NPM1) binds to promoter specifically TNBC cells and activates transcription, thus inhibiting T activity vitro vivo. Furthermore, demonstrate PARP1 suppresses transcription through its with the nucleic acid binding...
Clinical trials frequently include multiple end points that mature at different times. The initial report, typically on the based primary point, may be published when key planned co-primary or secondary analyses are not yet available. Trial Updates provide an opportunity to disseminate additional results from studies, in JCO elsewhere, for which point has already been reported.We previously reported significantly improved failure-free survival using gemcitabine plus cisplatin induction...
Abstract Background Nearly 90% locoregionally advanced nasopharyngeal carcinoma (LANPC) responds to induction chemotherapy (IC) with significant tumor volume shrinkage. Radiotherapy always follows IC, and reduced has been proposed. However, the efficacy safety of reduced‐volume radiotherapy is uncertain. Methods In this multi‐center, noninferiority, randomized, controlled trial, patients LANPC who completed IC were randomly assigned (1:1) receive based on post‐IC (Post‐IC group) or...
Melatonin exhibits anti-inflammatory and anticancer effects could be a chemopreventive chemotherapeutic agent against cancers, but the precise mechanisms involved remain largely unresolved. In this study, we evaluated mechanism of action melatonin in human MDA-MB-361 breast cancer cells. at pharmacological concentrations (10(-3) m) significantly suppressed cell proliferation induced apoptosis dose-dependent manner. The observed suppression was accompanied by melatonin-mediated inhibition...
// Jian-Jun Lu 1, * , Lingyi Fu 2, 3, Zhipeng Tang 4, Changlin Zhang 2 Lijun Qin 5 Jingshu Wang Zhenlong Yu 4 Dingbo Shi Xiangsheng Xiao Fangyun Xie Wenlin Huang 6 Wuguo Deng 1 Department of Thoracic Surgery, The First Affiliated Hospital, Yat-sen University, Guangzhou, China Sun University Cancer Center, State Key Laboratory Oncology in South China, Collaborative Innovation Center Medicine, 3 Guangdong General Academy Medical Sciences, Institute Stem Cell, Dalian Dalian, Pediatrics,...
Abstract Nasopharyngeal carcinoma (NPC)-mediated immunosuppression within the tumor microenvironment (TME) frequently culminates in failure of otherwise promising immunotherapies. In this study, we identify tumor-intrinsic FLI1 as a critical mediator impairing T cell anti-tumor immunity. A mechanistic inquiry reveals that orchestrates expression CBP and STAT1, facilitating chromatin accessibility transcriptional activation IDO1 response to cell-released IFN-γ. This regulatory cascade...
LBA6000 Background: Patients with high-risk locoregionally advanced nasopharyngeal carcinoma (NPC) often experience disease relapse even after receiving standard-of-care treatment, e.g. induction chemotherapy (IC) followed by concurrent chemoradiotherapy (CCRT). The benefit of PD-1 inhibitor as adjuvant treatment following IC+CCRT in NPC remains unclear. Methods: (T4N1M0 or T1-4N2-3M0) who have received gemcitabine and cisplatin (GP) IC CCRT were recruited at 11 centers China. They randomly...
JCO
Background: The poor prognosis of locoregionally advanced nasopharyngeal carcinoma (LANPC) due to the high incidence metastasis necessitates effective treatment strategies. Synergistic effects have been observed when anti-programmed death-1 (PD-1) inhibitors are combined with chemotherapy or targeted therapy. Objectives: To compare efficacy and safety induction in combination nimotuzumab without anti-PD-1 for LANPC. Design: Retrospective study. Methods: In total, 319 patients LANPC were...
Melatonin is an indoleamine secreted by the pineal gland as well a plant-derived product that exerts potential anti-inflammatory properties, but mechanisms of action remain unclear. Here, we investigated roles melatonin in regulation proinflammatory mediators and identified underlying human vascular smooth muscle (VSM) cell line CRL1999 stimulated lipopolysaccharide (LPS). We found treatment with significantly inhibited production expression TNF-α interleukin (IL)-1β, cyclooxygenase-2...
To address whether sparing the medial retropharyngeal lymph node (MRLN) region from elective irradiation volume provides non-inferior local relapse-free survival versus standard radiotherapy in patients with nasopharyngeal carcinoma. Open-label, non-inferiority, multicentre, randomised, phase 3 trial. Three Chinese hospitals between 20 November 2017 and December 2018. Adults (18-65 years) newly diagnosed, non-keratinising, non-distant metastatic carcinoma without MRLN involvement....
TFAP2A is a transcription factor that orchestrates variety of cell processes, including growth and tissue differentiation. However, the regulation in human nasopharyngeal carcinoma tumorigenesis its precise mechanism action remain largely unknown. In this study, we investigated biologic role clinical significance progression identified underlying molecular mechanisms. We found was highly expressed various lines tumor specimens significantly correlated with hypoxia-inducible factor-1α...
This study aimed to evaluate the efficacy of concurrent chemoradiotherapy (CCRT) for stage II nasopharyngeal carcinoma (NPC) patients treated with intensity-modulated radiation therapy (IMRT). A total 249 were retrospectively reviewed. All IMRT. One hundred forty-three CCRT and 106 IMRT alone. With a median follow-up 59.4 months, adding chemotherapy did not statistically significantly improve 5-year overall survival (OS) (89.7 % vs 99.0 %, p = 0.278), locoregional relapse-free (LRFS) (94.8...
Abstract Background Radiotherapy resistance is the main cause of treatment failure in nasopharyngeal carcinoma (NPC), which leads to poor prognosis. It urgent elucidate molecular mechanisms underlying radiotherapy resistance. Methods RNA-seq analysis was applied five paired progressive disease (PD) and complete response (CR) NPC tissues. Loss-and gain-of-function assays were used for oncogenic function FLI1 both vitro vivo. analysis, ChIP dual luciferase reporter performed explore...
LBA6002 Background: Despite the success of PD-1 blockade plus chemotherapy in recurrent/metastatic NPC, its role LANPC is unproven. This trial evaluated efficacy and safety adding sintilimab (a inhibitor) to IC-CCRT LANPC. Methods: Patients with non-metastatic high-risk (stage III-IVA, excluding T3-4N0/T3N1) were enrolled at 9 centers China, randomized (1:1; stratified by center stage block size four) Standard Arm (gemcitabine cisplatin IC CCRT), or Sintilimab (sintilimab IC-CCRT). 200mg was...
Abstract Background Induction chemotherapy (IC) followed by concurrent chemoradiotherapy is the mainstay treatment for patients with locoregionally advanced nasopharyngeal carcinoma. However, some obtain little benefit and experience unnecessary toxicities from IC. We intended to develop a gene-expression signature that can identify beneficiaries of Methods screened chemosensitivity-related genes comparing profiles short-term tumor response or nonresponse IC (n = 95) using microarray...
The significance of SOX2 in nasopharyngeal carcinoma (NPC), a tumor associated with Epstein–Barr virus (EBV), remains unclear. Here, we reported that, the univariate analysis, expression was correlated poorer distant metastasis-free survival (DMFS). EBV-VCA/IgA titers patients NPC were also overall (OS). Patients NPC, who had both strong staining and high EBV-VCA/IgA, poorest prognoses. Therefore, or combination level could be valuable to predict metastasis prognosis NPC.
Our objective was to examine whether adding induction chemotherapy concurrent chemoradiotherapy improved survival in stage III nasopharyngeal carcinoma (NPC) patients, especially low-risk patients at T3N0-1.We retrospectively analyzed 687 with T3N0-1 NPC treated intensity-modulated radiation therapy (IMRT) plus (CC) or without (IC). Propensity score matching (PSM) method used select 237 pairs of from two cohorts. Overall (OS), locoregional relapse-free (LRFS), distant metastasis-free (DMFS),...