A5100331752- Head and Neck Cancer Studies
- Head and Neck Surgical Oncology
- Lung Cancer Treatments and Mutations
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Research Studies
- Lung Cancer Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Salivary Gland Tumors Diagnosis and Treatment
- Viral-associated cancers and disorders
- RNA Interference and Gene Delivery
- Radiomics and Machine Learning in Medical Imaging
- Cancer Diagnosis and Treatment
- Nanoparticle-Based Drug Delivery
- Ear and Head Tumors
- Polyomavirus and related diseases
- Cancer Genomics and Diagnostics
- Supramolecular Self-Assembly in Materials
- Phase Equilibria and Thermodynamics
- Health Systems, Economic Evaluations, Quality of Life
- Electrocatalysts for Energy Conversion
- Hematopoietic Stem Cell Transplantation
- Ferroptosis and cancer prognosis
- Advanced battery technologies research
Sun Yat-sen University Cancer Center
2016-2025
Sun Yat-sen University
2016-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2025
Chinese Society of Clinical Oncology
2025
Chinese Society of Endocrinology
2025
Tianjin Medical University Cancer Institute and Hospital
2024
Shanghai Jiao Tong University
2023-2024
Capital Medical University
2010-2024
Northwest A&F University
2024
National Institute of Metrology
2024
Platinum-based concurrent chemoradiotherapy is the standard of care for patients with locoregionally advanced nasopharyngeal carcinoma. Additional gemcitabine and cisplatin induction chemotherapy has shown promising efficacy in phase 2 trials.
Abstract Nasopharyngeal carcinoma (NPC) is a malignant epithelial tumor originating in the nasopharynx and has high incidence Southeast Asia North Africa. To develop these comprehensive guidelines for diagnosis management of NPC, Chinese Society Clinical Oncology (CSCO) arranged multi‐disciplinary team comprising experts from all sub‐specialties NPC to write, discuss, revise guidelines. Based on findings evidence‐based medicine China abroad, domestic have iteratively developed provide proper...
<h3>Importance</h3> Concurrent chemoradiotherapy has been the standard treatment for stage II nasopharyngeal carcinoma (NPC) based on data using 2-dimensional conventional radiotherapy. There is limited evidence role of chemotherapy with use intensity-modulated radiation therapy (IMRT). <h3>Objective</h3> To assess whether concurrent can be safely omitted patients low-risk II/T3N0 NPC treated IMRT. <h3>Design, Setting, and Participants</h3> This multicenter, open-label, randomized, phase 3,...
Clinical trials frequently include multiple end points that mature at different times. The initial report, typically on the based primary point, may be published when key planned co-primary or secondary analyses are not yet available. Trial Updates provide an opportunity to disseminate additional results from studies, in JCO elsewhere, for which point has already been reported.We previously reported significantly improved failure-free survival using gemcitabine plus cisplatin induction...
Abstract Although radiotherapy can promote antitumour immunity, the mechanisms underlying this phenomenon remain unclear. Here, we demonstrate that expression of E3 ubiquitin ligase, tumour cell-intrinsic tripartite motif-containing 21 (TRIM21) in tumours, is inversely associated with response to radiation and CD8 + T cell-mediated immunity nasopharyngeal carcinoma (NPC). Knockout TRIM21 modulates cGAS/STING cytosolic DNA sensing pathway, potentiates antigen-presenting capacity NPC cells,...
The AJCC/UICC TNM classification describes anatomic extent of tumor progression and guides treatment decisions. Our comprehensive analysis 8,834 newly diagnosed patients with non-metastatic Epstein-Barr virus related nasopharyngeal carcinoma (NPC) from six Chinese centers indicates certain limitations in the current staging system. 8th edition inadequately differentiates patient outcomes, particularly between T2 T3 categories within N classification. We propose reclassifying cases NPC early...
Abstract Background Nearly 90% locoregionally advanced nasopharyngeal carcinoma (LANPC) responds to induction chemotherapy (IC) with significant tumor volume shrinkage. Radiotherapy always follows IC, and reduced has been proposed. However, the efficacy safety of reduced‐volume radiotherapy is uncertain. Methods In this multi‐center, noninferiority, randomized, controlled trial, patients LANPC who completed IC were randomly assigned (1:1) receive based on post‐IC (Post‐IC group) or...
3D nanosheets consisting of N-doped carbon conglutinated CoFe alloy nanoparticles have been constructed, in which the can enhance bifunctional oxygen reaction for a high-performance Zn–air battery.
LBA6000 Background: Patients with high-risk locoregionally advanced nasopharyngeal carcinoma (NPC) often experience disease relapse even after receiving standard-of-care treatment, e.g. induction chemotherapy (IC) followed by concurrent chemoradiotherapy (CCRT). The benefit of PD-1 inhibitor as adjuvant treatment following IC+CCRT in NPC remains unclear. Methods: (T4N1M0 or T1-4N2-3M0) who have received gemcitabine and cisplatin (GP) IC CCRT were recruited at 11 centers China. They randomly...
Importance Approximately 20% to 30% of patients with locoregionally advanced nasopharyngeal carcinoma (NPC) experience disease relapse despite definitive chemoradiotherapy. The programmed cell death 1 (PD-1) blockade camrelizumab has demonstrated considerable value in recurrent or metastatic NPC, while its role NPC is unclear. Objective To evaluate the efficacy and safety adjuvant for NPC. Design, Setting, Participants Randomized, open-label, multicenter, phase 3 clinical trial conducted...
Development of efficient noble metal-free electrocatalysts for accelerating the sluggish kinetics in hydrogen evolution reaction (HER) has received a great deal attention electrolytic water splitting. Herein, we present facile one-step solvothermal strategy controllably constructing homojunction structures Ni3S2 nanosheets situ epitaxially grown on nanorods by using Ni foam as self-support substrate and nickel resource (Ni3S2/NF). In synthesis, cetyltrimethylammonium bromide hydrazine...
Background: Due to the lack of studies, it remains unclear whether additional neoadjuvant chemotherapy (NACT) concurrent chemoradiotherapy (CCRT) is superior CCRT alone for locoregionally advanced nasopharyngeal carcinoma (NPC).The main objective this Bayesian network meta-analysis was determine efficacy NACT+CCRT as compared with alone.Methods: We comprehensively searched databases and extracted data from randomized controlled trials involving NPC patients who received NACT+CCRT, CCRT,...
Abstract The prognostic value of the tumour response to induction chemotherapy (IC) for long-term survival outcomes after intensity-modulated radiation therapy in nasopharyngeal carcinoma (NPC) remains unknown. We retrospectively reviewed 1811 consecutive patients with newly diagnosed NPC treated using IMRT, and 399 eligible pre- post-induction magnetic resonance images were recruited. clinicopathological features different responses compared Chi-square test or Fisher’s exact test....
Abstract Treatment of hepatocellular carcinoma (HCC) requires sustained suppression tumor cell growth and metastasis for long‐term efficacy. However, traditional intratumoral drug delivery system always exhibits burst release with less therapeutic outcomes. Here, a new self‐assembling amphiphilic peptide conjugate (SAAPDC) is fabricated as “two‐in‐one” nanofiber comprising hexapeptide matrix metalloproteinases (MMP) inhibitor doxorubicin (DOX) the treatment HCC. The results indicate that...
To address whether sparing the medial retropharyngeal lymph node (MRLN) region from elective irradiation volume provides non-inferior local relapse-free survival versus standard radiotherapy in patients with nasopharyngeal carcinoma. Open-label, non-inferiority, multicentre, randomised, phase 3 trial. Three Chinese hospitals between 20 November 2017 and December 2018. Adults (18-65 years) newly diagnosed, non-keratinising, non-distant metastatic carcinoma without MRLN involvement....
Glutamate-induced excitotoxicity has been implicated in the etiology of stroke, epilepsy, and neurodegenerative diseases. NMDA receptors (NMDARs) play a pivotal role excitotoxic injury; however, clinical trials testing NMDAR antagonists as neuroprotectants have discouraging. The development novel neuroprotectant molecules is being vigorously pursued. Here, we report that downstream regulatory element antagonist modulator (DREAM) significantly inhibits surface expression NMDARs NMDAR-mediated...