A5026500902- RNA modifications and cancer
- Cancer, Lipids, and Metabolism
- RNA Research and Splicing
- Cancer Cells and Metastasis
- Cholesterol and Lipid Metabolism
- Colorectal Cancer Surgical Treatments
- interferon and immune responses
- Thyroid and Parathyroid Surgery
- Sperm and Testicular Function
- Cancer-related molecular mechanisms research
- Chromosomal and Genetic Variations
- Reconstructive Surgery and Microvascular Techniques
- Epigenetics and DNA Methylation
- Thyroid Cancer Diagnosis and Treatment
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Drug Transport and Resistance Mechanisms
- Animal Genetics and Reproduction
- Ferroptosis and cancer prognosis
- Aortic Disease and Treatment Approaches
- Aortic aneurysm repair treatments
- Genomics and Chromatin Dynamics
- Monoclonal and Polyclonal Antibodies Research
- Head and Neck Anomalies
- Bladder and Urothelial Cancer Treatments
- Colorectal Cancer Treatments and Studies
Sichuan University
2018-2025
Hubei University of Chinese Medicine
2008-2024
State Key Laboratory of Biotherapy
2018-2023
Shanghai Jiao Tong University
2023
Renji Hospital
2023
Capital University
2022
Capital Medical University
2022
Xinqiao Hospital
2022
Army Medical University
2021-2022
West China Hospital of Sichuan University
2020-2022
Abstract DEAD box helicase 17 (DDX17) has been reported to be involved in the initiation and development of several cancers. However, functional role mechanisms DDX17 colorectal cancer (CRC) malignant progression metastasis remain unclear. Here, we that expression was increased CRC tissues compared with noncancerous mucosa further upregulated liver patient-paired primary tumors. High levels were significantly correlated aggressive phenotypes worse clinical outcomes patients. Ectopic promoted...
Metastasis is a major cause of colorectal cancer (CRC) mortality, but its molecular mechanisms are still not fully understood. Here, we show that upregulated DDX39B correlates with liver metastases and aggressive phenotypes in CRC. an independent prognostic factor associated poor clinical outcome CRC patients. We demonstrate Sp1 potently activates transcription by directly binding to the GC box promoter cells. overexpression augments proliferation, migration, invasion cells, while opposite...
Abstract Breast cancer is the most common in world. Relapse and metastasis are important factors endangering life of breast patients, but mechanism still unclear. The stabilization p53 essential for preventing carcinogenesis, ubiquitination one main ways to regulate stability p53. Tripartite motif-containing 31 (TRIM31) a new member TRIM family functions as an E3 ubiquitin ligase. It acts promoter or suppressor malignant processes multiple cancers. However, function TRIM31 progression...
Background: The prognosis of patients with stage III colorectal cancer (CRC) shows significant variations. purpose this study was to investigate the role key regulatory proteins in glycolysis and lipid metabolism for prognostic evaluation CRC patients. Methods: Utilizing Cancer Genome Atlas (TCGA) database, we analyzed expression various genes pathways CRC, as well relationship between gene levels overall survival. We selected top two exhibiting differential patterns metabolism, namely,...
Abstract Breast cancer is the most frequently diagnosed malignancy and leading cause of cancer‐related deaths in women worldwide. Cancer‐associated fibroblasts (CAFs) are one fundamental cellular components tumor microenvironment play a critical role initiation, progression, therapy resistance breast cancer. However, detailed molecular mechanisms CAFs activation from normal (NFs) still not well understood. In present study, we reported that ZNF32 expression cells was negatively correlated...
Abstract Background Dihydroartemisinin (DHA) is an artemisinin derivative known for its antimalarial properties. It has also shown potential as anti‐tumor and anti‐angiogenic agent. However, specific role in inhibiting angiogenesis breast cancer not well understood. Objectives We aimed to investigate the anti‐angiogenesis effect of DHA on explore a therapeutic drug. Our objectives were assess impact neovascularization induced by MDA‐MB‐231 cells, evaluate effects vessel sprout tube‐formation...
Breast cancer is one of the leading causes death in women. Due to existence a small fraction stem cell-like subpopulations, some breast subtypes exhibit very high malignancy and resistance multiple therapies. The underlying mechanisms how these acquire properties progress more aggressively remain largely unknown. Zinc finger protein 32 (ZNF32), newly discovered transcription factor, has been reported be associated with progression. However, many questions about its target genes exact...
Tongue squamous cell carcinoma (TSCC) is one of the most common malignant tumors among oral cancers, and its treatment based on radio-chemotherapy surgery, which always produces more serious side effects sequelae. Traditional medicine can compensate for shortcomings modern medical treatments play a better therapeutic role. Currently, active ingredients derived from plants are attracting attention researchers clinical professionals. We examined capsaicin (CAP), an ingredient isolated Capsicum...
Cisplatin (DDP) is a potent and widely applied chemotherapeutic agent. However, its clinical efficacy for the treatment of liver cancer limited by adverse effects development resistance. Combinatorial therapy may alleviate these issues. Dihydroartemisinin (DHA) first-generation derivative artemisinin. The DDP on when in combination with DHA have not previously been studied. Therefore, present study aimed to investigate combined HepG2 cells their potential underlying molecular mechanisms....
Objective . The aim of this study was to identify the risk factors associated with central lymph node metastasis (CLNM) in patients clinically node-negative conventional papillary thyroid carcinoma (cN 0 CPTC). Methods A total 190 cN CPTC who underwent thyroidectomy prophylactic neck dissection (pCND) Department General Surgery at Guangdong Hospital between March 2014 and December 2015 were assessed retrospectively. relations CLNM clinicopathologic characteristics analyzed by univariate...