A5026151733- Mechanisms of cancer metastasis
- Cancer Mechanisms and Therapy
- Bioactive natural compounds
- Berberine and alkaloids research
- Calpain Protease Function and Regulation
- Wnt/β-catenin signaling in development and cancer
- Metabolism, Diabetes, and Cancer
- Axon Guidance and Neuronal Signaling
- Bioactive Compounds and Antitumor Agents
- MicroRNA in disease regulation
- Endoplasmic Reticulum Stress and Disease
- Nerve injury and regeneration
- Cancer Cells and Metastasis
- Barrier Structure and Function Studies
Central South University
2025
Hubei University of Chinese Medicine
2022-2024
The combined analysis of dual diseases can provide new insights into pathogenic mechanisms, identify novel biomarkers, and develop targeted therapeutic strategies. Polycythemia vera (PV) is a chronic myeloproliferative neoplasm associated with risk acute myeloid leukemia (AML) transformation. However, the nature disease transformation complicates longitudinal high-throughput sequencing studies patients PV before after AML This study aimed to diagnostic model for malignant proliferative...
Capsaicin (CAP) exerts significant anti-tumor effects on a variety of tumors, with low intrinsic toxicity.Cisplatin (DDP) is currently the first-line drug for treatment oral cancer; however, its clinical efficacy impeded by chemoresistance and negligible side effects.Whether combined use CAP DDP has synergistic antitumor effect tongue squamous cell carcinoma (TSCC) cells underlying mechanisms remains unclear.The present study revealed that reduced activity TSCC in dose-and time-dependent...
Tongue squamous cell carcinoma (TSCC) is one of the most common malignant tumors among oral cancers, and its treatment based on radio-chemotherapy surgery, which always produces more serious side effects sequelae. Traditional medicine can compensate for shortcomings modern medical treatments play a better therapeutic role. Currently, active ingredients derived from plants are attracting attention researchers clinical professionals. We examined capsaicin (CAP), an ingredient isolated Capsicum...
The role of Claudin-1 in tongue squamous cell carcinoma (TSCC) metastasis needs further clarification, particularly its impact on migration. Herein, our study aims to investigate the TSCC migration and underlying mechanisms.
Abstract Cisplatin is commonly used for the chemotherapy of tongue squamous cell carcinoma (TSCC); however, adverse side effects and drug resistance impact its therapeutic efficacy. Capsaicin an active ingredient in chili peppers that exerts antitumor effects, whether it on cisplatin‐resistant cells remains unknown. Therefore, this study, we investigated effect capsaicin cisplatin TSCC explored underlying mechanisms. A line was established by treated with increasing concentrations. Combined...
Capsaicin is a lipid-soluble vanillin alkaloid extracted from Capsicum plants in the Solanaceae family, which main active ingredient capsicum, with multiple functions such as anti-inflammation, analgesia, cardiovascular expansion, and gastric mucosa protection. Recently, capsaicin has been confirmed potential antitumor compound. It can induce cell cycle arrest, inhibit cancer proliferation, metastasis, invasion, angiogenesis, promote apoptosis or autophagy malignancy models animal of lung...