A5008305264- Wnt/β-catenin signaling in development and cancer
- Cancer-related gene regulation
- Cancer Genomics and Diagnostics
- Cancer-related Molecular Pathways
- Peptidase Inhibition and Analysis
- Pharmacological Effects of Medicinal Plants
- Flavonoids in Medical Research
- Connexins and lens biology
- RNA modifications and cancer
- Endoplasmic Reticulum Stress and Disease
- Cancer Immunotherapy and Biomarkers
- Protease and Inhibitor Mechanisms
- Skin and Cellular Biology Research
- Genomics and Chromatin Dynamics
- Barrier Structure and Function Studies
- Hippo pathway signaling and YAP/TAZ
- Redox biology and oxidative stress
- Calcium signaling and nucleotide metabolism
- RNA and protein synthesis mechanisms
- Epigenetics and DNA Methylation
- Cancer Cells and Metastasis
- Single-cell and spatial transcriptomics
- Metabolism, Diabetes, and Cancer
- Cell death mechanisms and regulation
- RNA Interference and Gene Delivery
Anhui University of Traditional Chinese Medicine
2025
Tianjin Medical University
2022-2024
Hubei University of Chinese Medicine
2024
Lanzhou University
2024
Hangzhou Medical College
2024
Triple-negative breast cancer (TNBC) is the most aggressive subtype of with a high risk distant metastasis, an extremely poor prognosis, and death. Regulatory T cells (Tregs) contribute to formation tumor immunosuppressive microenvironment, which plays important role in progression treatment resistance TNBC.A public single-cell sequencing dataset demonstrated increased infiltration Tregs TNBC tissues relative normal tissue. Weighted gene co-expression network analysis was used identify Treg...
Abstract Background Polyploid giant cancer cells (PGCCs), a specific type of stem (CSCs), can be induced by hypoxic microenvironments, chemical reagents, radiotherapy, and Chinese herbal medicine. Moreover, PGCCs produce daughter that undergo epithelial–mesenchymal transition, which leads to recurrence disseminated metastasis. Vimentin, mesenchymal cell marker, is highly expressed in their (PDCs) drives migratory persistence. This study explored the molecular mechanisms vimentin...
Saffron, a traditional Chinese medicine, is derived from Crocus sativus L. stigmas and has been reported to possess neuroprotective properties potentially contribute the inhibition of apoptosis inflammation. Safranal, potent monothyral aldehyde, main component saffron that have antiepileptic activity. However, specific mechanism by which safranal suppresses epileptic seizures via its antiapoptotic anti-inflammatory unclear.
High concentrations of cobalt chloride (CoCl<sub>2</sub>) can induce the formation polyploid giant cancer cells (PGCCs) in various tumors, which produce daughter with strong proliferative, migratory and invasive abilities via asymmetric division. To study role hypoxia‑inducible factor (HIF) 1α PGCCs, colon cell lines Hct116 LoVo were used as experimental subjects. Western blotting, nuclear cytoplasmic protein extraction immunocytochemical experiments to compare changes expression subcellular...
Tongue squamous cell carcinoma (TSCC) is one of the most common malignant tumors among oral cancers, and its treatment based on radio-chemotherapy surgery, which always produces more serious side effects sequelae. Traditional medicine can compensate for shortcomings modern medical treatments play a better therapeutic role. Currently, active ingredients derived from plants are attracting attention researchers clinical professionals. We examined capsaicin (CAP), an ingredient isolated Capsicum...
The role of Claudin-1 in tongue squamous cell carcinoma (TSCC) metastasis needs further clarification, particularly its impact on migration. Herein, our study aims to investigate the TSCC migration and underlying mechanisms.
Abstract Objectives The splicing factor transformer‐2 homolog beta (Tra2β) plays a pivotal role in various cancers. Nonetheless, its oral squamous cell carcinoma (OSCC) has not been comprehensively explored. This study sought to discern the influence of Tra2β on OSCC and underlying mechanisms. Materials Methods We assessed expression utilizing immunohistochemistry, qRT‐PCR, western blotting techniques. siRNA transfection was used silence Tra2β. Whole transcriptome RNA sequencing (RNA‐seq)...