Cyclophosphamide (CTX) is an antitumor drug commonly used to treat various cancer types. Unfortunately, its toxic side effects, including gastrointestinal (GI) toxicity, affect treatment compliance and patients' prognosis. Thus, there a critical need of evaluating strategies that may improve the associated GI toxicity induced by CTX. In this work, we evaluated capacity epigallocatechin-3-gallate (EGCG), major constituent green tea, recovery gut injury CTX in mice. Treatment with for 5 days...

Abstract Purpose: The use of costimulatory molecules targeting distinct T-cell signaling pathways has provided a means for triggering and enhancing antitumor immunity; however, it is still not fully understood what types are suitable the combination in tumor therapy. Our purpose this study to establish an effective immune approach by using molecule 4-1BBL with soluble PD-1. Experimental Design: murine H22 hepatocarcinoma served as ectopic model. Local gene transfer was done injection naked...

Abstract Background Dihydroartemisinin (DHA) is an artemisinin derivative known for its antimalarial properties. It has also shown potential as anti‐tumor and anti‐angiogenic agent. However, specific role in inhibiting angiogenesis breast cancer not well understood. Objectives We aimed to investigate the anti‐angiogenesis effect of DHA on explore a therapeutic drug. Our objectives were assess impact neovascularization induced by MDA‐MB‐231 cells, evaluate effects vessel sprout tube‐formation...

Natural plants are considered as a huge treasure for anticancer. Amomum tsaoko, plant of Zingiberaceae, is used widely food and traditional medicine in East Asia. In previous studies, tsaoko has antitumor effect on liver cancer cells, but the mechanism not clear. Here, we demonstrated that ethanol extract from (At-EE) could inhibit ovarian decrease angiogenesis vivo. At-EE did influence vascular endothelial cells directly, decreased IL-6 VEGF secreted by to through inhibition p-STAT3 NF-kB...

Capsaicin (CAP) exerts significant anti-tumor effects on a variety of tumors, with low intrinsic toxicity.Cisplatin (DDP) is currently the first-line drug for treatment oral cancer; however, its clinical efficacy impeded by chemoresistance and negligible side effects.Whether combined use CAP DDP has synergistic antitumor effect tongue squamous cell carcinoma (TSCC) cells underlying mechanisms remains unclear.The present study revealed that reduced activity TSCC in dose-and time-dependent...

Tri- and tetracyclic heterocycle systems were constructed by a palladium-catalyzed domino reaction of linear 1,6-dienes that contain acryl groups with aryl halides through C-C coupling aromatic C-H functionalization. Three different acrylamides have been shown to be very active for the reaction. The substituents on could ethoxycarbonyl, ketyl, chloro, sulfonyl, cyano, etc. Thus, ready accessibility starting materials, wide range compatibility substrates including both dienes halides,...

// Feng-Hua Wu 1, 2 , Lei Mu 1 Xiao-Lan Li Yi-Bing Hu Hui Liu Lin-Tao Han and Jian-Ping Gong Cancer Research Institution, Tongji Hospital, Medical College, Huazhong University of Science Technology, Wuhan 430032, People's Republic China Department Physiology, Hubei Chinese Medcine, 430065, Correspondence to: Gong, email: jpgong@tjh.tjmu.edu.cn Keywords: slow-cycling tumor cells, cancer stem cell, DC-CIK, adoptive transfer, dormancy Received: August 04, 2016 Accepted: May 22, 2017 Published:...

The paper demonstrates the method to set up pipe network hydraulic-thermal synthetic mode by applying hydraulic and thermal models of single pipe, proposes algorithm based on searching for problem that iterative calculation sometimes cannot derive convergent reasonable result as well. Compared calculated values with measurements, it shows validation model effectiveness algorithm.

Abstract Unlike the intact fibronectin (FN) molecule, some proteolytic or recombinant fragments of FN possess inhibitory activities on tumor, providing potential strategies in tumor therapeutics. Using hydrodynamics‐based gene delivery technique, we demonstrated that treatment by vivo expression a CBD‐HepII polypeptide FN, designated as CH50, strongly inhibited growth, invasion and angiogenesis. Such effects CH50 were partly ascribed to its influence MMP‐9 αvβ3 integrin. The expressed...

Tongue squamous cell carcinoma (TSCC) is one of the most common malignant tumors among oral cancers, and its treatment based on radio-chemotherapy surgery, which always produces more serious side effects sequelae. Traditional medicine can compensate for shortcomings modern medical treatments play a better therapeutic role. Currently, active ingredients derived from plants are attracting attention researchers clinical professionals. We examined capsaicin (CAP), an ingredient isolated Capsicum...

The role of Claudin-1 in tongue squamous cell carcinoma (TSCC) metastasis needs further clarification, particularly its impact on migration. Herein, our study aims to investigate the TSCC migration and underlying mechanisms.

Cisplatin (DDP) is a potent and widely applied chemotherapeutic agent. However, its clinical efficacy for the treatment of liver cancer limited by adverse effects development resistance. Combinatorial therapy may alleviate these issues. Dihydroartemisinin (DHA) first-generation derivative artemisinin. The DDP on when in combination with DHA have not previously been studied. Therefore, present study aimed to investigate combined HepG2 cells their potential underlying molecular mechanisms....

Abstract An efficient domino cyclization method for the construction of aza‐podophyllotoxin/aza‐conidendrin derivatives has been established. Reactions different dienes with aryl halides in presence a palladium catalytic system produced kinds podophyllotoxin through highly regioselective CH functionalization. Treatment that have electron‐withdrawing substituents on phenyl ring created aza‐podophyllotoxin by means functionalization bonds ortho to Chalide incoming halides. The reaction...

Fr. Schmidt, a Traditional Chinese Medicine, has been used in the treatment of rheumatoid arthritis (RA) for numerous years. However, specific mechanisms remain to be elucidated. Thus, present study aimed investigate main chemical constituents and potential

In breast cancer, tumor-associated macrophages with activated phenotypes promote tumor invasion and metastasis. The more aggressive mesenchymal-like cancer cells have a selective advantage, skewing toward the immunosuppressive subtype. However, mechanism underlying this shift is poorly understood. Cyclin D1b highly oncogenic variant of cyclin D1. Our previous study showed that non-metastatic epithelial-like were metastatic in vivo when was overexpressed. present determined whether...

Abstract Purpose Dihydroartemisinin (DHA), a derivative of artemisinin that is well-known as an antimalarial drug, has been reported to have anti-tumor and anti-angiogenesis effects. However, whether how it inhibits angiogenesis in breast cancer poorly understood. In this study, we detected the effect DHA on cancer. Methods Firstly, detect chick chorioallantois membrane model. Then, collected conditioned medium MDA-MB-231cells used aortic ring assay, HUVECs migration tube formation assay....