A5030492984- Esophageal and GI Pathology
- Eosinophilic Esophagitis
- Gastroesophageal reflux and treatments
- NF-κB Signaling Pathways
- Immune Response and Inflammation
- Helicobacter pylori-related gastroenterology studies
- Acute Ischemic Stroke Management
- Plant Disease Management Techniques
- Monoclonal and Polyclonal Antibodies Research
- Mosquito-borne diseases and control
- Immune cells in cancer
- Viral Infections and Vectors
- TGF-β signaling in diseases
- Immune Cell Function and Interaction
- Clinical practice guidelines implementation
- Vector-borne infectious diseases
- Cell Adhesion Molecules Research
- Phenothiazines and Benzothiazines Synthesis and Activities
- Advanced Glycation End Products research
- Histone Deacetylase Inhibitors Research
- Health Promotion and Cardiovascular Prevention
- Cardiovascular Health and Risk Factors
- Gastrointestinal Bleeding Diagnosis and Treatment
- Ocular Infections and Treatments
- Gastrointestinal disorders and treatments
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2025
Xiyuan Hospital
2022-2025
Henan University of Technology
2024-2025
Fujian Medical University
2014-2024
First Affiliated Hospital of Henan University
2024
Nanjing University of Information Science and Technology
2024
First Affiliated Hospital of Fujian Medical University
2014-2024
Zhejiang A & F University
2024
Huazhong Agricultural University
2023
South China Agricultural University
2022
Neutrophils are known to have antitumor potential. However, in recent years the tumor-promoting effect of neutrophils has been well demonstrated. So far, it remains unclear what causes conversion neutrophil function from tumor suppressive promoting. In this article, we report that murine occurs bone marrow, and IL-6 cooperation with G-CSF is required for conversion. cooperated modulate altering activation potential signaling pathways neutrophils, especially STAT3. Costimulation induced a...
Tomatoes ( Solanum lycopersicum L. Micro-Tom) were grown in a plastic greenhouse. When plants anthesis, the 100 μmol m –2 s –1 blue light-emitting diode (LED) light (430 ± 10 nm) was supplemented from 6:00 to 18:00. There 5 treatments, which contained different frequencies with same intensity: S6 (30 min and 30 pause), S8 15 S10 8 S12 (continuous for 12 h), control (CK) (natural light, without any supplemental light). Agronomic traits nutritional qualities of tomato fruits measured at 30,...
Abstract Targeted regulation using transgrafting technology has become a trend. However, the mechanisms of transgene-derived signal communication between rootstocks and scions remain unclear in woody plants. Here, we grafted wild-type (WT) walnut (Juglans regia L.) on WT (WT/WT), JrGA20ox1 (encodes gibberellin 20-oxidase)-overexpressing (WT/OE), JrGA20ox1-RNAi transformation (WT/RNAi) vitro. We aimed to elucidate JrGA20ox1-derived under PEG-simulated drought stress walnut. demonstrated that...
Background Tension-type headache (TTH) is the most common type of and second health-related complaint among children adults. Traditional Chinese medicine (TCM) offers unique therapeutic benefits in treating TTH. However, lack standardized evidence—such as inconsistencies outcome selection reporting clinical studies, a consensus on outcomes measures, high risks selective bias, missing data—has limited development robust evidence supporting efficacy TCM Therefore, establishing core set (COS)...
Soybean is an important legume crop and has significant agricultural economic value. P4-ATPases (aminophospholipid ATPases, ALAs), one of the classes P-type can transport or flip phospholipids across membranes, creating maintaining lipid asymmetry playing crucial roles in plant growth development. To date, however, ALA gene family its expression patterns under abiotic biotic stresses have not been studied soybean genome. A total 27 GmALA genes were identified genome these unevenly...
Preconditioning with ligands of toll-like receptors (TLRs) is a powerful neuroprotective approach whereby low dose stimulus confers significant protection against subsequent substantial brain damage by reprogramming the ischemia-activated TLRs signaling. Herein, we aim to explore whether preconditioning recombinant high-mobility group box 1 (rHMGB1), one ligands, decreases cerebral ischemia-reperfusion injury (IRI). Rats were intracerebroventricularly pretreated rHMGB1, or 3 days before...
Jasmonates, such as jasmonic acid (JA) and methyl jasmonate (MeJA), are crucial aspect of black tea quality. However, lipids species, hormones genes regulated mechanism in the biosynthesis during processing lacking. In this study, we employed lipidomics, hormone metabolism analysis, transcriptome profiling associated with MeJA pathway to investigate these factors. The contents GLs, PLs TAG decreased, accompanied main species reduced, processing. Galactolipids, primarily 34:3/36:6/36:3 DGDG...
Gr-1(+)CD11b(+)F4/80(+) cells play important roles in tumor development and have a negative effect on immunotherapy. So far, the mechanisms underlying regulation of their immunosuppressive phenotype by classical alternative macrophage activation stimuli are not well elucidated. In this study, we found that molecules from necrotic (NTC-Ms) stimulated to induce apoptosis activated T but nonstimulated cells. The apoptosis-inducing capacity was determined higher expression levels arginase I...
TGF-β1 has the potential to activate multiple signaling pathways required for inducing metastatic of tumor cells. However, was inefficient in many non-invasive human Here we report that enhancement is breast cancer alone could not efficiently induce sustained activation Smad and non-Smad TLR4 ligand (LPS) H2O2 cooperated with enhance pathways, including p38MAPK, ERK, JNK, PI3K, NF-κB. The MAPK PI3K resulted a positive feed-back effect on by down-regulating Nm23-H1 expression up-regulating...
Introduction Zanthoxylum bungeanum Maxim is an economically significant crop in Asia, but large-scale cultivation often threatened by frequent diseases, leading to yield declines. Deep learning-based methods for disease recognition have emerged as a vital research area agriculture. Methods This paper presents novel model, LT-DeepLab, the semantic segmentation of leaf spot (folium macula), rust, frost damage (gelu damnum), and diseased leaves trunks complex field environments. The proposed...
Polyunsaturated fatty acids (PUFAs) play various roles in inflammation. However, the effect of PUFAs development reflux esophagitis (RE) is unclear. This study to investigate potential n-3/n-6 on acute RE rats along with underlying protective mechanisms.Forty Sprague Dawley were randomly divided into four groups (n = 10 each group). model was established by pyloric clip and section ligation. Fish oil- soybean oil-based emulsion (n-3 n-6 groups), or normal saline (control sham operation...
Abstract Background Apathy is a neuropsychiatric symptom frequently observed in patients with cognitive impairment. It has been found to be predictor of conversion from mild impairment (MCI) dementia Alzheimer disease type. However, this association between apathy and not yet confirmed vascular MCI, especially post‐stroke MCI. The aim study was evaluate whether would increase the risk MCI after 6 months. Method A prospective multi‐centre cohort performed 14 clinics seven provinces cities...
To investigate the effect of MDA-19 on progression melanoma, and explore relevant mechanism.The melanoma cell lines, M14 UACC257, were treated with different concentrations MDA-19, then CCK8, clone formation assay, Transwell flow cytometry assays performed to examine proliferation, migration, invasion apoptosis, respectively. The expression apoptosis-related proteins (Bcl-2, Bax caspase 3 P17), EMT signaling pathway-related also detected by Western blot.MDA-19 inhibited cells in a...
Scope Aged laying hen is recently suggested as a more attractive animal model than rodent for studying nonalcoholic fatty liver disease (NAFLD) of humans. This study aims to reveal effects and metabolic regulation mechanisms taurine alleviating NAFLD by using the aged model. Methods results Liver histomorphology biochemical indices show 0.02% effectively alleviated fat deposition damage. Comparative lipidomics gene expressions analyses promoted lipolysis, acids oxidation, lipids transport,...
Nano-antibodies possess great potential in many applications. However, they are naturally derived from heavy chain-only antibodies (HcAbs), which lack light chains and the CH1 domain only found camelids sharks. In this study, we investigated whether precise genetic removal of exon γ1 gene enabled production a functional IgG1 mice. chain dimers lacking associated were detected sera genetically modified modification led to decreased expression but increased other IgG subclasses. The mice...
The targeting of αvβ3 is a promising therapeutic strategy for suppressing tumor metastasis. However, it unclear whether the efficacy could be influenced by metastasis-promoting factor(s) in vivo. Here we report that Toll-like receptor 4 (TLR4) ligand released from damaged cells or bacteria had negative effect on recombinant CBD-HepII polypeptide fibronectin (CH50) suppresses metastasis αvβ3. TLR4 antagonize inhibitory CH50 cell adhesion and invasion promoting expression activity cells. also...