A5100330532- Endometriosis Research and Treatment
- Ovarian function and disorders
- Reproductive System and Pregnancy
- Endometrial and Cervical Cancer Treatments
- Reproductive Biology and Fertility
- Uterine Myomas and Treatments
- Signaling Pathways in Disease
- Estrogen and related hormone effects
- COVID-19 Clinical Research Studies
- Cancer-related molecular mechanisms research
- Intraocular Surgery and Lenses
- Assisted Reproductive Technology and Twin Pregnancy
- Pain Mechanisms and Treatments
- RNA modifications and cancer
- RNA Interference and Gene Delivery
- Long-Term Effects of COVID-19
- Hedgehog Signaling Pathway Studies
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- Reproductive Health and Technologies
- Immune Response and Inflammation
- Cell Adhesion Molecules Research
- Ovarian cancer diagnosis and treatment
- Pregnancy-related medical research
- Protease and Inhibitor Mechanisms
Huazhong University of Science and Technology
2016-2025
Union Hospital
2016-2025
Jinzhou Medical University
2023-2025
First Affiliated Hospital of Zhengzhou University
2025
Universiti Sains Malaysia
2024-2025
Hebei Medical University
2020-2024
West China Medical Center of Sichuan University
2024
Kirin (United States)
2024
Wuhan University
2020-2024
Southern Medical University
2021-2024
Abstract Tocilizumab (TCZ), a monoclonal antibody against interleukin‐6 (IL‐6), emerged as an alternative treatment for COVID‐19 patients with risk of cytokine storms recently. In the present study, we aimed to discuss response TCZ therapy in infected patients. The demographic, treatment, laboratory parameters C‐reactive protein (CRP) and IL‐6 before after clinical outcome 15 were retrospectively assessed. Totally included this study. Two them moderately ill, six seriously ill seven...
Abstract Brain damage induced by ischemia promotes the development of cognitive dysfunction, thus increasing risk dementia such as Alzheimer's disease (AD). Studies indicate that cellular acidification‐triggered activation asparagine endopeptidase (AEP) plays a key role in ischemic brain injury, through multiple molecular pathways, including cleavage its substrates SET (inhibitor 2 PP2A, I PP2A ) and Tau. However, whether direct targeting AEP can effectively prevent post‐stroke impairment...
Under fasting conditions, increases in circulating concentrations of pancreatic glucagon maintain glucose homeostasis through induction gluconeogenic genes by the CREB coactivator CRTC2. Hepatic CRTC2 activity is elevated obesity, although extent to which this cofactor contributes attendant insulin resistance unclear. Here we show that mice with a knockout gene have decreased during fasting, due attenuation program. was found stimulate hepatic expression part an N-terminal binding domain...
Although tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has shown efficacy in a phase 2 clinical trial, development of resistance to TRAIL by cells is major roadblock. We investigated whether quercetin, flavonoid, can sensitize human ovarian cancer TRAIL. Results indicate that quercetin sensitized The induced expression death receptor DR5 but did not affect DR4 cells. induction was mediated through activation JNK and upregulation transcription factor CCAAT enhancer-binding...
Endometriosis is a benign gynecological disease that shares some characteristics with malignancy like migration and invasion. It has been reported both hypoxia-inducible factor-1α (HIF-1α) autophagy were upregulated in ectopic endometrium of patients ovarian endometriosis. However, the crosstalk between HIF-1α pathogenesis endometriosis remains to be clarified. Accordingly, we investigated whether was regulated by HIF-1α, as well effect on cell invasion mediated through upregulation. Here,...
Apigenin (APG), a widely distributed flavonoid in vegetables and fruits, with low toxicity, nonmutagenic characteristic, has been reported to have many targets. Evidence indicates that APG can inhibit the proliferation, migration, invasion, metastasis of some tumor cells, but mechanism, specifically lung cancer, is unclear. The phosphoinositide 3-kinase (PI3K)/Akt signaling pathway regulates diverse set cellular functions relevant growth progression including survival, invasion. Our results...
Quercetin suppresses DNA double-strand break repair and enhances the radiosensitivity of human ovarian cancer cells via p53-dependent endoplasmic reticulum stress pathway Cheng Gong,1 Zongyuan Yang,1 Lingyun Zhang,2 Yuehua Wang,2 Wei Gong,2 Yi Liu3 1Department Obstetrics Gynecology, Tongji Hospital, Medical College, Huazhong University Science Technology, Wuhan, 2Department Oncology, XiangYang Central Hubei Arts Science, XiangYang, 3Department Medicinal Chemistry, School Pharmacy, Chinese...
Hepatocellular carcinoma (HCC) is one of the most common cancers with highest morbidity and mortality. It necessary to develop new anti-liver cancer drugs. Itraconazole a popular systemic anti-fungal drug strong anti-tumor effect. However, so far, it not clear whether itraconazole has specific effect on liver cancer. The purpose this study was investigate resistant explore its potential anti-cancer mechanism. proliferation cells studied MTT assay. Flow cytometry used determine apoptosis,...
How does hypoxia promote growth of lesions in the development endometriosis? Hypoxia induces epithelial–mesenchymal transition (EMT) endometrial cells, resulting changes cellular characteristics, which may be a prerequisite for establishment endometriotic lesions. Up-regulated hypoxia-inducible factor 1α (HIF-1α) has recently been found ectopic There is increasing evidence that EMT, epithelial cells acquire mesenchymal and migratory properties, also play role disease. EMT induced by HIF-1α...
Osteoarthritis (OA) is a common chronic and degenerative joint condition that mainly characterized by cartilage degradation, osteophyte formation stiffness. The NF-κB signaling pathways in inflammation, autophagy apoptosis play prominent role the progression of OA. Icariin, prenylated flavonol glycoside extracted from Epimedium, have been proven to exert anti-osteoporotic anti-inflammatory effects However, action mechanisms its effect on chondrocytes has yet be elucidated. In present study,...
Endometriosis is an estrogen-dependent benign gynecological disease that shares some common features of malignancy. Epithelial-mesenchymal transition (EMT) has been recognized as a core mechanism endometriosis. MALAT1 widely known EMT promoter, while miR200 family members (miR200s) are considered inhibitors. Previous studies have reported upregulation and miR200s downregulation observed in MiR200c regarded the strongest member to interact with MALAT1. However, whether MALAT1/miR200c...
Abstract Endometriosis is a common gynecological disease characterized by diminished apoptosis, sustained ectopic survival of dysfunctional endometrial cells. Hypoxia has been implicated as crucial microenvironmental factor that contributes to endometriosis. It reported long non‐coding RNA MALAT 1 (lnc ‐ 1) highly expressed in endometriosis and up‐regulated hypoxia. may also induce autophagy, which might act cell protective mechanism. However, the relationship between lnc autophagy under...
N 6-methyladenosine (m6A), one of the most abundant RNA modifications, is involved in progression many diseases, but its role and related molecular mechanisms endometriosis remain unknown. To address these issues, we detected m6A levels normal, eutopic, ectopic endometrium found decreased eutopic compared with normal endometrium. In addition, proved that methyltransferase-like 3 (METTL3) downregulation accounted for reduction endometriosis. Furthermore, observed METTL3 knockdown facilitated...
Do estrogen and Wnt/β-catenin signaling promote vascular endothelial growth factor (VEGF) expression in endometriosis how? 17β-Estradiol (E2)-drives β-catenin triggered up-regulation of VEGF effector human primary endometrial stromal cells (ESCs) thus enhances their ability to establish a new blood supply the exfoliated endometrium. Implantation survival endometrium is crucially dependent on neovascularization plays an important role stimulating angiogenesis. Expression levels mRNA, receptor...
There is an urgent need to make cisplatin (cDDP) more effective and less toxic in the treatment of ovarian cancer for its systemic side effects high resistance rate. In this study, we investigated effect quercetin (Qu) pretreatment on potentiation cDDP cancer. We found that Qu significantly enhanced cytotoxicity cell line primary cells. addition, demonstrated elicited obvious endoplasmic reticulum stress ( ERS ) activated all three branches Specific inhibitors each pathway, as well general...
Endometriosis is an estrogen-dependent disease that involves the adhesion, invasion, and angiogenesis of endometrial tissues outside uterine cavity. We hypothesized a link exists between estrogen beta-catenin (β-catenin) signaling in pathogenesis endometriosis. Human stromal cells (HESCs) were separated from eutopic obtained patients with β-catenin expression invasiveness ability up-regulated by 17β-estradiol (E2) receptor (ESR)-dependent manner, whereas siRNA abrogated this phenomenon....
Abstract Purpose: Glioma-initiating cells (GIC) are glioma stem–like that contribute to glioblastoma (GBM) development, recurrence, and resistance chemotherapy radiotherapy. They have recently become the focus of novel treatment strategies. Cyclophilin A (CypA) is a cytosolic protein belongs peptidyl–prolyl isomerase (PPIase) family major intracellular target immunosuppressive drug cyclosporin (CsA). In this study, we investigate functions CypA its mechanism action in GICs' development....
Abstract Endometriosis is an oestrogen‐dependent disease, and epithelial‐mesenchymal transition (EMT) involved in the process of endometriosis. Whether oestrogen could induce EMT endometriosis remains largely unknown. Here, we reported that up‐regulated expression markers ovarian chocolate cyst accompanied by high 17β‐hydroxysteroid dehydrogenase 1 (17β‐HSD1), exposure primary human endometrial epithelial cells to oestradiol conditions promote occurrence activate both β‐catenin Snail...
Recent studies have suggested a potential link between systemic inflammatory regulators and primary ovarian insufficiency (POI); however, causal relationship them remains unclear. In this study, we explored the POI risk using bidirectional, two-sample Mendelian randomization (MR) strategy.This approach utilized most extensive genome-wide association study involving 41 in sample of 8,293 Finnish individuals data from FinnGen consortium (254 cases vs. 118,228 controls). The inverse variance...
Background. Hepatic ischemia/reperfusion (I/R) injury (HIRI) is an intrinsic phenomenon observed in the process of various liver surgeries. Unfortunately, there are currently few options available to prevent HIRI. Accordingly, we aim explore role and key downstream effects B-cell lymphoma 6 (BCL6) hepatic I/R (HIR). Methods. BCL6 expression levels were measured tissue primary hepatocytes stimulated by hypoxia/reoxygenation (H/R). Moreover, ascertained effect on HIR vivo using liver-specific...