A5026216464- Pluripotent Stem Cells Research
- Immune Cell Function and Interaction
- Immune cells in cancer
- Pulmonary Hypertension Research and Treatments
- Cancer Immunotherapy and Biomarkers
- CRISPR and Genetic Engineering
- Epigenetics and DNA Methylation
- Immunotherapy and Immune Responses
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- COVID-19 Impact on Reproduction
- COVID-19 Clinical Research Studies
- CAR-T cell therapy research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Erythrocyte Function and Pathophysiology
- Head and Neck Cancer Studies
- SARS-CoV-2 and COVID-19 Research
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Misinformation and Its Impacts
- Cardiovascular Function and Risk Factors
- Physical Activity and Health
- COVID-19 and Mental Health
- Renal and related cancers
- Extracellular vesicles in disease
Guangzhou Medical University
2020-2025
Chongqing Medical University
2020-2025
Sun Yat-sen Memorial Hospital
2025
Sun Yat-sen University
2019-2025
Zhongnan Hospital of Wuhan University
2015-2024
Wuhan University
2015-2024
Guangzhou Sport University
2022-2024
Southern Medical University
2023-2024
Second Affiliated Hospital of Xinjiang Medical University
2024
Xinjiang Medical University
2024
DNA methylation plays an important role in development and disease. The primary sites of vertebrates are cytosines the CpG dinucleotide context, which account for roughly three quarters total content human mouse cells. While genomic distribution, inter-individual stability, functional reasonably well understood, little is known about targeting CpA, CpT, CpC (non-CpG) dinucleotides. Here we report a comprehensive analysis non-CpG 76 genome-scale maps across pluripotent differentiated cell...
Domesticated ungulate pluripotent embryonic stem (ES) cell lines would be useful for generating precise gene-modified animals. To date, many efforts have been made to establish domesticated ES cells from early embryos without success. Here, we report the generation of porcine-induced (iPS) using drug-inducible expression defined factors. We showed that porcine iPS expressed alkaline phosphatase, SSEA3, SSEA4, Tra-1-60, Tra-1-81, Oct3/4, Nanog, Sox2, Rex1 and CDH1. Pig high levels telomerase...
A tumor-specific pro-IL-12 rejuvenated preexisting TILs to induce tumor growth delay without inducing systemic toxicity.
Tumor-associated macrophages (TAMs) are pivotal immune cells within the tumor microenvironment (TME), exhibiting dual roles across various cancer types. Depending on context, TAMs can either suppress progression and weaken drug sensitivity or facilitate growth drive therapeutic resistance. This study explores whether targeting of head neck squamous cell carcinoma (HNSCC) improve efficacy chemotherapy. Bioinformatics analyses were performed to evaluate infiltration levels in HNSCC tissues...
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Abstract Exposure to the spike protein or receptor-binding domain (S-RBD) of SARS-CoV-2 significantly influences endothelial cells and induces pulmonary vascular endotheliopathy. In this study, angiotensin-converting enzyme 2 humanized inbred (hACE2 Tg) mice cultured were used investigate how protein/S-RBD impacts endothelium. Results show that S-RBD leads acute-to-prolonged induction intracellular free calcium concentration ([Ca 2+ ] i ) via acute activation TRPV4, prolonged upregulation...
Cell fate commitment of pre-implantation blastocysts, to either the inner cell mass or trophoblast, is first step in lineage segregation developing human embryo. However, intercellular signals that control determination these cells remain obscure. Human embryonic stem (hESCs) provide a unique model for studying early development. We have previously shown Activin/Nodal signaling contributes maintaining pluripotency hESCs, which are derivatives mass. Here we further demonstrate inhibition...
BACKGROUNDDespite an increasing appreciation of the roles that myeloid cells play in tumor progression and therapy, challenges remain interpreting tumor-associated response balance its translational value. We aimed to construct a simple reliable signature for hepatocellular carcinoma (HCC).METHODSUsing situ immunohistochemistry, we assessed distribution major subtypes both peri- intratumoral regions HCC. A 2-feature-based, myeloid-specific prognostic signature, named score (MRS), was...
Concentric pulmonary vascular wall thickening due partially to increased artery (PA) smooth muscle cell (PASMC) proliferation contributes elevating resistance (PVR) in patients with hypertension (PH). Although vasoconstriction may be an early contributor increasing PVR, the transition of contractile PASMCs proliferative play important role development and progression remodeling PH. A rise cytosolic Ca 2+ concentration ([Ca ] cyt ) is a trigger for PASMC contraction proliferation. Here, we...
The constrained cross-talk between myeloid cells and T in the tumor immune microenvironment (TIME) restricts cancer immunotherapy efficacy, whereas underlying mechanism remains elusive. Parkin, an E3 ubiquitin ligase renowned for mitochondrial quality control, has emerged as a regulator of response. Here, we show that both systemic macrophage-specific ablations Parkin mice lead to attenuated progression prolonged mouse survival. By single-cell RNA-seq flow cytometry, demonstrate deficiency...
There is an urgent need to make cisplatin (cDDP) more effective and less toxic in the treatment of ovarian cancer for its systemic side effects high resistance rate. In this study, we investigated effect quercetin (Qu) pretreatment on potentiation cDDP cancer. We found that Qu significantly enhanced cytotoxicity cell line primary cells. addition, demonstrated elicited obvious endoplasmic reticulum stress ( ERS ) activated all three branches Specific inhibitors each pathway, as well general...