A5070242627- Nicotinic Acetylcholine Receptors Study
- Suicide and Self-Harm Studies
- MicroRNA in disease regulation
- Tryptophan and brain disorders
- Extracellular vesicles in disease
- Autism Spectrum Disorder Research
- Functional Brain Connectivity Studies
- Bipolar Disorder and Treatment
- Mental Health Research Topics
- Treatment of Major Depression
- Maternal Mental Health During Pregnancy and Postpartum
- Advanced Neuroimaging Techniques and Applications
- interferon and immune responses
- COVID-19 and Mental Health
- GABA and Rice Research
- Cannabis and Cannabinoid Research
- Neurogenesis and neuroplasticity mechanisms
- Thyroid Disorders and Treatments
- Genetic Neurodegenerative Diseases
- Human Health and Disease
- Personality Disorders and Psychopathology
- Attention Deficit Hyperactivity Disorder
- Stress Responses and Cortisol
- Nerve injury and regeneration
- Radiation Dose and Imaging
Chongqing Medical University
2018-2025
First Affiliated Hospital of Kunming Medical University
2020
Kunming Medical University
2020
Major depressive disorder (MDD) seriously endangers adolescent mental and physical health. Extracellular vesicles (EVs) are mediators of cellular communication involved in many physiological brain processes. Although EV miRNAshave been implicated adults with major psychiatric disorders, investigation into their effects MDDremains scarce. In discovery set, we conducted a genome-wide miRNA sequencing serum EVs from 9 untreated adolescents MDD 8 matched healthy controls (HCs), identifying 32...
Abstract Background Major depressive disorder is characterized by a high risk of relapse. We aimed to compare the prophylactic effects different antidepressant medicines (ADMs). Methods PubMed, Cochrane Central Register Controlled Trials, Embase and Web Science were searched on 4 July 2019. A pooled analysis parametric survival curves was performed using Bayesian framework. The main outcomes hazard ratios (HRs), relapse-free mean months. Results Forty randomized controlled trials included....
Purpose: Uric acid (UA) is thought to exert neuroprotective roles. The purpose of this study was examine the association serum UA with suicide attempts (SA) in adolescents and young adults major depressive disorder (MDD). Patients Methods: We retrospectively recruited 533 participants MDD aged 13 25 years, which 168 had a history SA past three months 365 did not have SA. Serum levels were measured using uricase-peroxidase coupling method. In addition overall level comparison individuals...
Brain ageing is thought to be related geriatric depression, but the relationship between and depression among middle aged individuals unknown. The present study aimed evaluate whether age-related reduction of brain cortical thickness (CT) can found in adult first-episode MDD patients, as well identify possible genetic effect ANK3 gene polymorphism age-relates CT reduction. This recruited 153 patients with a disease duration < 2 years 276 healthy controls (HC), 68 whole regions two SNPs...
To explore the differential expression of microRNAs (miRNAs) in brain-derived exosomes (BDEs) adolescent mice with depression-like behavior.The experimental group consisted susceptible exposed to chronic social defeat stress (CSDS), and sucrose preference test (SPT) open field (OFT) were performed evaluate their behaviors. BDEs extracted by ultracentrifugation (UC). The morphology, particle size, surface marker proteins examined transmission electron microscopy, nano-flow cytometry Western...
Abstract Background Adolescence and young adulthood are considered the peak age for emergence of many psychiatric disorders, in particular major depressive disorder (MDD). Previous research has shown substantial heritability MDD. In addition, brain‐derived neurotrophic factor ( BDNF ) gene is known to be associated with However, there been no study conducting targeted sequencing MDD patients so far. Method To examine whether occurrence patients, we used detect variants 259 Chinese Han people...
Purpose: The aim of our study was to explore the relation between serum levels non-enzymatic antioxidants, thyroid function with risk non-suicidal self-injury (NSSI) in depressed adolescents. Patients and Methods: We retrospected electronic records 454 hospitalized patients aged 13– 17 years old a diagnosis major depressive disorder (239 NSSI 215 subjects without NSSI), collected their demographic clinical information, including total bilirubin (Tbil), uric acid (UA), free triiodothyronine...
Objective To explore the correlation between polymorphisms (SNPs) of locus rs2269272 glial high-affinity glutamate transporter (SLC1A3) gene and suicide attempt among Chinese adolescents. Methods iMLDR™ genotyping technology was used to detect polymorphism SLC1A3 loci in 55 attempters 112 healthy controls, survival analysis applied analyze relationship allele (T) age attempt. Results The differences distribution two groups were statistically significant(χ2= 4.208, P=0.040), but...
To investigate the changes in serum inflammatory cytokines and predictive factors for efficacy of sertraline following medication therapy adolescents with first-episode major depressive disorder (MDD).A total 61 adolescent patients drug-naïve MDD were enrolled group 55 healthy control (HC) group. Sertraline tablets administered to 8 weeks after enrollment, while no was given HC In group, blood samples collected measure cytokine levels clinical data, including scores 17-item Hamilton...
Objective: To explore the effects of X-ray repair cross complementing gene 1 (XRCC1) polymorphism and low dose ionizing radiation exposure on radiology professionals' peripheral blood lymphocyte micronucleus. Methods: A matched case-control study was designed. From 2013 to 2015, 102 professionals with micronucleus test rusults, 45 cases present were enroled into case group. 180 diagnostic technicians detecting no chosen as control group, controls 1∶4 mached gender, age ≤40 or >40 years old....