A5100320818- Pharmacological Effects of Natural Compounds
- Smoking Behavior and Cessation
- RNA Research and Splicing
- Rheumatoid Arthritis Research and Therapies
- Phytochemical and Pharmacological Studies
- Phytochemistry and Biological Activities
- Cancer Genomics and Diagnostics
- Plant-based Medicinal Research
- Computational Drug Discovery Methods
- Spectroscopy Techniques in Biomedical and Chemical Research
- Software-Defined Networks and 5G
- Cancer-related molecular mechanisms research
- Liver Disease Diagnosis and Treatment
- Traditional Chinese Medicine Studies
- Sarcoma Diagnosis and Treatment
- Bladder and Urothelial Cancer Treatments
- Berberine and alkaloids research
- Cancer Immunotherapy and Biomarkers
- Receptor Mechanisms and Signaling
- Lymphoma Diagnosis and Treatment
- Fluorine in Organic Chemistry
- Air Quality and Health Impacts
- Endoplasmic Reticulum Stress and Disease
- Bone Metabolism and Diseases
- Seaweed-derived Bioactive Compounds
Xihua University
2010-2025
China Medical University
2020-2024
Renmin Hospital of Wuhan University
2023-2024
Institute of Quality Standards and Testing Technology for Agro Products
2024
Chinese Academy of Agricultural Sciences
2024
Tianjin Institute of Industrial Biotechnology
2020-2024
Chinese Academy of Sciences
2015-2024
Chongqing Medical University
2004-2024
Second Affiliated Hospital of Chongqing Medical University
2004-2024
Dalian Medical University
2004-2024
As compared with cigarette smoking, use of Swedish snus is associated significantly fewer health risks. Nicotine pouches (NPs), a new form oral nicotine product, are smokeless and tobacco-free, comprising nicotine-containing cellulose matrix inside fiber pouch. NPs similar in appearance/use to snus, but without tobacco, have the potential further reduce tobacco-related harm. This study aimed evaluate toxicant levels estimate their position on tobacco/nicotine product continuums delivery...
Nucleus pulposus cell (NPC) death and progressive reduction play important roles in intervertebral disc degeneration (IVDD). As part of a damage-associated molecular pattern, mitochondrial DNA (mtDNA) can be recognized by TLR9 triggers the expression NF-κB NLRP3 inflammasomes, inducing pyroptosis inflammatory response. However, whether mtDNA induces NPC via TLR9-NF-κB-NLRP3 axis promotes IVDD remains uncertain.We constructed an vitro oxidative stress injury model to clarify mechanism...
Background Endoplasmic reticulum stress (ERS) is a critical factor in the development of ulcerative colitis (UC); however, underlying molecular mechanisms remain unclear. This study aims to identify pivotal related ERS UC pathogenesis and provide novel therapeutic targets for UC. Methods Colon tissue gene expression profiles clinical information patients healthy controls were obtained from Gene Expression Omnibus (GEO) database, ERS-related set was downloaded GeneCards analysis. Weighted...
A mild and efficient DBN-mediated addition reaction of α-(trifluoromethyl)styrenes with diazoles, triazoles, tetrazoles, primary, secondary, secondary cyclic amines was developed. This practical protocol provided a robust method for the synthesis various β-trifluoromethyl nitrogen-containing heterocycles amines.
Abstract Gastric cancer (GC) is often diagnosed in the advanced stages with a poor prognosis. Thymoquinone (TQ) known for its antitumor activity; however, specific mechanism GC remains unknown. In our study, TQ inhibited cell proliferation and induced apoptosis autophagy concentration‐dependent manner. Transmission electron microscopy showed increased autophagosome formation cells treated TQ. Meanwhile, LC3B puncta LC3BII protein levels were significantly cells, while p62 expression was...
Vapour products have demonstrated potential to be a lower-risk alternative cigarettes. The present study describes novel hybrid tobacco product that combines warm aerosol stream generated by an electronic vaporisation mechanism with top flavour from cut tobacco. During operation, the released vapour cartomiser is passed through bed of blended puffing flow, elevating temperature and eluting volatile components. A preliminary but comprehensive analysis composition found emissions were...
Numerous clinical conditions have been linked to ectopic mineralization (EM). This process of pathological biomineralization is complex and not fully elucidated, but thought be started within matrix vesicles (MVs). We hypothesized that high mobility group box 1 (HMGB1), a cytokine associated with biomineralizing under physiological conditions, induces EM via promoting MVs secretion from macrophages. In this study, we found HMGB1 significantly promoted macrophages subsequently led mineral...
This study assessed the toxicological and biological responses of aerosols from a novel hybrid tobacco product. Toxicological product were compared to those commercially available Tobacco Heating Product (c-THP), prototype THP (p-THP) 3R4F reference cigarette, using in vitro test methods which outlined as part framework substantiate risk reduction potential nicotine products. Exposure matrices used included total particulate matter (TPM), whole aerosol (WA), aqueous extracts (AqE) obtained...
Nicotine lactate, nicotine tartrate, benzoate, and freebase (FBN) are four forms of salt systems that present in tobacco products. However, few vivo studies have compared their pharmacological (pK) efficacies, which important for understanding roles the addiction abuse In this work, pK above was studied by subcutaneously injecting aqueous solutions rats obtaining blood samples from jugular vein. levels were analyzed LC-MS/MS. The results demonstrated rapid absorption occurred all systems. Of...
The morphological identification of different Hippophae species (Shaji) was difficult. This study aims to discriminate between medicinal and non-medicinal by DNA barcodes, the ITS2, psbA-trnH, a combination ITS2 psbA-trnH (ITS2 + psbA-trnH).DNA extracted from dried fruit samples. Primer pairs ITS2F/3R for psbAF/trnHR were used PCR amplification. purified products bidirectionally sequenced. Genetic distances calculated according Kimura 2 parameter model phylogenetic tree constructed based on...
Ershiwuwei Lvxue Pill (ELP, མགྲིན་མཚལ་ཉེར་ལྔ།), a traditional Tibetan medicine preparation, has been used hundreds of years for the clinical treatment rheumatoid arthritis (RA) in highland region Tibet, China. Nevertheless, its chemical composition and therapeutic mechanism are unclear. This study aimed to uncover potentially effective components ELP pharmacological mechanisms against RA by combing UPLC-Q-TOF/MS network pharmacology. In this study, 96 compounds were identified or tentatively...