A5103040378- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Lipid metabolism and disorders
- Circular RNAs in diseases
- Probiotics and Fermented Foods
- Peroxisome Proliferator-Activated Receptors
- Protein Hydrolysis and Bioactive Peptides
- Advanced Glycation End Products research
- Curcumin's Biomedical Applications
- Epigenetics and DNA Methylation
- Thyroid Disorders and Treatments
- Genomics, phytochemicals, and oxidative stress
- Food Industry and Aquatic Biology
- Proteins in Food Systems
- Microencapsulation and Drying Processes
- Microbial Inactivation Methods
- Anesthesia and Neurotoxicity Research
- GABA and Rice Research
- Renin-Angiotensin System Studies
- Growth Hormone and Insulin-like Growth Factors
- Hedgehog Signaling Pathway Studies
- Genetic Syndromes and Imprinting
- Animal Diversity and Health Studies
- Biopolymer Synthesis and Applications
- Congenital heart defects research
First Affiliated Hospital of Bengbu Medical College
2017-2024
Instituto Estadual de Diabetes e Endocrinologia Luiz Capriglione
2019-2020
Weatherford College
2019-2020
Bengbu Medical College
2019-2020
Shandong University
2018
Peking University
2008
microRNAs (miRNAs) play an important role in development and are associated with birth defects. Data scant on the of miRNAs defects arising from exposure to environmental factors such as alcohol.In this study, we determined expression levels 509 mature fetal mouse brains or without prenatal ethanol using a miRNA microarray technique, verified by northern blot PCR. Mouse embryos culture were used examine effect treatment putative target genes miR-10a (Hoxa1 other Hox members) at mRNA protein...
To clarify the reciprocal influence between fortified bacterial powder of Lacticaseibacillus paracasei JY025 (LBP) with milk matrix during gastrointestinal digestion and storage period, characteristics stability (LFMP) were explored in this study by vitro simulated accelerated storage. The results showed that significantly improved survival (the highest improvement 27%) period 37%), which suggests can be an effective strategy to enhance viability probiotics period. Moreover, physicochemical...
Dysfunction of vascular endothelial cells often results in diabetic complications. Circular RNAs (circRNAs) have been implicated the pathogenesis various diseases, including diabetes and many diseases. This study aimed to explore roles circRNAs high glucose‐induced human umbilical vein (HUVECs) elucidate contributions We subjected control HUVECs RNA sequencing identified 214 differentially expressed (versus HUVECs, fold change ≥ 2.0, P < 0.05). then validated seven these by qPCR (...
The intervention of circular RNA HIPK3 (circHIPK3) in diabetes has drawn increasing attention recent years. However, the underlying mechanism circHIPK3 diabetic nephropathy (DN) not been fully elucidated. Thus, current study aims to investigate role high glucose (HG)-induced toxicity human renal tubular epithelial HK-2 cells.The expression cells induced by HG was determined qRT-PCR and Western blot. regulatory effects miR-326/miR-487a-3p on proliferative apoptosis were evaluated CCK-8 flow...
Abstract Diabetic nephropathy (DN) represents a major diabetes-related complication, which could undermine renal function. CircCOL1A2 has been previously reported to show abnormal expression during DN. However, its functional role in the progression of DN, as well potential molecular mechanisms, remains unclear. The present work examined circCOL1A2 plasma DN patients, and employed high glucose (HG)-challenged HK-2 cells vitro cell model hyperglycemia (HG)-induced was silenced using siRNA...
Abstract Background Diabetes mellitus is often associated with microvascular and macrovascular lesions, hyperglycemia-induced vascular endothelial cell damage a key factor. Methods We investigated long non-coding RNAs (lncRNAs) mRNAs that are affected by using human umbilical vein cells (HUVECs) as model. HUVECs were cultured under high (25 mmol/L) or normal (5 glucose conditions for 6 d, then lncRNAs protein-coding transcripts profiled RNA-seq. Result Among 40,379 screened, 214 upregulated...
Diabetic nephropathy (DN) is one of the most common and serious complications diabetes, which can lead to renal failure fatality. miRNAs are an important class endogenous non-coding RNAs implicated in a wide range biological processes pathological conditions. This study aims investigate potential functional roles miR-543 DN its underlying mechanisms.qRT-PCR was performed detect expression levels TSPAN8 kidney tissues mice with DN. Western blot (WB) used measure protein levels. CCK8 assay...
Purpose: A long-term "memory" of hyperglycemic stress, even when glycemia is normalized, has been previously reported in endothelial cells. However, the molecular mechanism "metabolic memory" (MM) remains unknown. In this report, we sought to screen at whole transcriptome level genes that participate MM. Methods: present research, RNA sequencing was used determine protein-coding mRNA expression profiles human umbilical vein cells (HUVECs) under normal-glucose concentration (LG), high-glucose...
Pseudohypoparathyroidism (PHP) is a rare genetic disease characterized by hypocalcemia, hyperphosphatemia, and elevated parathyroid hormone (PTH) in serum. Here, we report case of patient with pseudohypoparathyroidism type IB (PHPIB) subclinical hypothyroidism, analyze the clinical data his family members, review relevant literature, classify discuss pathogenesis characteristics each subtype. Finally, treatment approach to improve clinicians' understanding disease.
Thyroid hormone resistance syndrome (RTH) is a rare hereditary endocrine disease that can manifest as hyperthyroidism, hypothyroidism, or remain asymptomatic. It easily be confused with other types of thyroid diseases. The diagnosis the depends on genetic testing.
Abstract Background: Diabetes mellitus is often associated with microvascular and macrovascular lesions, hyperglycemia-induced vascular endothelial cell damage a key factor. Methods: We investigated long non-coding RNAs (lncRNAs) mRNAs that are affected by using human umbilical vein cells (HUVECs) as model. HUVECs were cultured under high (25 mmol/L) or normal (5 glucose conditions for 6 d, then lncRNAs protein-coding transcripts profiled RNA-seq. Results: Among 40,379 screened, 214...
Abstract Background: Diabetes mellitus is often associated with microvascular and macrovascular lesions, hyperglycemia-induced vascular endothelial cell damage a key factor. Methods： We investigated long non-coding RNAs (lncRNAs) mRNAs that are affected by using human umbilical vein cells (HUVECs) as model. HUVECs were cultured under high (25 mmol/L)or normal (5 mmol/L) glucose conditions for 6 d, then lncRNAs protein-coding transcripts profiled RNA-seq. Results： Among 40,379 screened, 214...
Abstract Background: Diabetes mellitus is often associated with microvascular and macrovascular lesions, hyperglycemia-induced vascular endothelial cell damage a key factor. Methods ： We investigated long non-coding RNAs (lncRNAs) mRNAs that are affected by using human umbilical vein cells (HUVECs) as model. HUVECs were cultured under high (25 mmol/L) or normal (5 glucose conditions for 6 d, then lncRNAs protein-coding transcripts profiled RNA-seq. Results Among 40,379 screened, 214...
Abstract Background: Diabetes mellitus is often associated with microvascular and macrovascular lesions, hyperglycemia-induced vascular endothelial cell damage a key factor. Methods： We investigated long non-coding RNAs (lncRNAs) mRNAs that are affected by using human umbilical vein cells (HUVECs) as model. HUVECs were cultured under high (25 mmol/L) or normal (5 glucose conditions for 6 d, then lncRNAs protein-coding transcripts profiled RNA-seq. Results： Among 40,379 screened, 214...