A5102844118- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Plant Pathogens and Resistance
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- Radiomics and Machine Learning in Medical Imaging
- Cancer Genomics and Diagnostics
- Plant Disease Resistance and Genetics
- MRI in cancer diagnosis
- Circular RNAs in diseases
- Molecular Biology Techniques and Applications
- Cancer, Lipids, and Metabolism
- Potato Plant Research
- Cancer Cells and Metastasis
- MicroRNA in disease regulation
- Genomics and Chromatin Dynamics
- Autophagy in Disease and Therapy
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Chromatography in Natural Products
- Plant-Microbe Interactions and Immunity
- Cervical Cancer and HPV Research
- PARP inhibition in cancer therapy
- Plant and fungal interactions
- interferon and immune responses
Agricultural Genomics Institute at Shenzhen
2021-2025
Chinese Academy of Agricultural Sciences
2021-2025
Ministry of Agriculture and Rural Affairs
2021-2025
First Affiliated Hospital of Bengbu Medical College
2024-2025
Southern Medical University
2025
Jiangsu Province Hospital
2019-2023
Nanjing Medical University
2019-2023
Beijing Radiation Center
2011-2020
Peking University
2013
North China University of Science and Technology
2009
Circular RNAs (circRNAs), a novel family of non-coding RNAs, play crucial roles in cancer progression. While the existing research focuses on nuclear genome-derived (nu)-circRNAs, biological and clinical characteristics mitochondrial (mt)-circRNAs remain largely unknown, especially chronic lymphocytic leukemia (CLL). In this study, we attempted to identify mc-COX2 (mitochondrial circRNAs [mc]), one mt-circRNAs that can be involved CLL were found highly expressed plasma exosomes patients. The...
Male breast cancer (MBC) is a rare but aggressive malignancy with cellular and immunological characteristics that remain unclear. Here, we perform transcriptomic analysis for 111,038 single cells from tumor tissues of six MBC thirteen female (FBC) patients. We find has significantly lower infiltration T relative to FBC. Metastasis-related programs are more active in MBC. The activated fatty acid metabolism involved FASN related cell metastasis low immune show activation p38 MAPK lipid...
Summary Anthocyanin biosynthesis and accumulation determines the colour of tuber flesh in potato ( Solanum tuberosum ) influences nutritional quality. However, regulatory mechanism behind anthocyanin remains unclear. In this study, we identified Pigmented Pf locus through a genome‐wide association study using 135 diploid landraces. Genome editing two tandem R2R3 MYB transcription factor genes, StMYB200 StMYB210 , within demonstrated that both genes are involved flesh. Molecular biochemical...
Heterosis is a fundamental biological phenomenon characterized by the superior performance of hybrids over their parents. Although tremendous progress has been reported in seed crops, molecular mechanisms underlying heterosis clonally propagated crops are largely unknown. Potato (Solanum tuberosum L.) most important tuber crop and an ongoing revolution transforming potato from tetraploid into seed-propagated diploid hybrid potato. In our previous study, we developed first generation highly...
In this study, expression of the SPC25 gene was characterized in breast cancer (BC), and its effects on BC development progression, functions cells, potential underlying mechanisms were examined. Data from TCGAportal FIREBROWSE indicated that upregulated tissues compared to normal tissues, CANCERTOOL higher mRNA levels associated with increased probability recurrence poorer survival patients. patients displayed shorter distant metastasis-free survival, relapse-free overall survival. Colony...
Triple-negative breast cancer (TNBC), a heterogeneous subtype of (BC), had poor prognosis. Endoplasmic reticulum (ER) stress was responsible for cellular processes and played crucial role in the cell function. ER is complex dynamic process that can induce abnormal apoptosis death. However, underlying mechanism involved TNBC not well defined.We identified ubiquitin-specific protease 19 (USP19) as negative regulator further investigation. The effects USP19 on BC proliferation were assessed...
The genetic analysis of potato is hampered by the complexity tetrasomic inheritance. An ongoing effort aims to transform clonally propagated tetraploid into a seed-propagated diploid crop, which would make analyses much easier owing disomic Here, we construct and report large-scale heterotic characteristics F
Two new azaphilone metabolites, named pseudohalonectrin A (1) and B (2), were isolated from the culture of aquatic fungus Pseudohalonectria adversaria YMF1.01019, originally separated submerged wood in Yunnan Province, China. Pseudohalonectrin assessed for their nematicidal activity against pine nematode Bursaphelenchus xylophilus structures defined after spectral analysis. This is first report secondary metabolites any member genus Pseudohalonectria.
Abstract The embryo spot trait leads to a deep purple or reddish coloration at the base of cotyledons embryo, visible on both sides flat potato ( Solanum tuberosum ) seeds. This has long been used by researchers and breeders as morphological marker during dihaploid induction. formation spots reflects accumulation anthocyanins, but genetic basis this remains unclear. In study, we mapped 6.78-Mb region end chromosome 10 using an F 2 population derived from cross between spotted spotless...
Purpose: This study explores the impact of microwave ablation on thyroid function in patients with Small Papillary Thyroid Carcinomas, using a specific energy/volume model to optimize treatment and evaluate clinical efficacy. Methods: A cohort 70 confirmed Carcinomas underwent tailored individual nodule characteristics. Pre- post-ablation assessments included ultrasound imaging for size, tests (TSH, Free T4, T3 levels) were conducted at baseline, 1, 3, 6, 12 months post-treatment. The main...
The recent development of artificial intelligence (AI) technologies coupled with medical imaging data has gained considerable attention, and offers a non-invasive approach for cancer diagnosis prognosis. In this context, improved breast (BC) molecular characteristics assessment models are foreseen to enable personalized strategies better clinical outcomes compared existing screening strategies. And it is promising developing hormone receptors (HR) subtypes BC patients from dynamic...
Breast cancer (BRCA) has become the highest incidence of due to its heterogeneity. To predict prognosis BRCA patients, sensitive biomarkers deserve intensive investigation. Herein, we explored role N 6 -methyladenosine-related long non-coding RNAs (m A-related lncRNAs) as prognostic in patients acquired from The Cancer Genome Atlas (TCGA; n = 1,089) dataset and RNA sequencing (RNA-seq) data ( 196). Pearson’s correlation analysis, univariate multivariate Cox regression were performed select m...
To investigate reliable associations between dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) features and gene expression characteristics in breast cancer (BC) to develop validate classifiers for predicting PAM50 subtypes prognosis from DCE-MRI non-invasively. Two radiogenomics cohorts with paired RNA-sequencing (RNA-seq) data were collected local public databases divided into discovery (n = 174) validation 72). Six external datasets 1,443) used prognostic validation....
Background: Breast cancer (BC) is a highly heterogeneous cancer. The interaction between immune system and BC complex, widespread yet unclear. In this study, we aimed to reveal the heterogeneity of host systemic response understand possible mechanisms that may drive using transcriptomic data from peripheral blood mononuclear cells (PBMCs). Methods: Transcriptome-wide gene expressions PBMCs in 33 patients were generated by RNA sequencing. An unsupervised clustering algorithm was employed...
Background: This study aimed to reveal the heterogeneity of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) breast cancer (BC) and identify its prognosis values molecular characteristics. Methods: Two radiogenomics cohorts (n = 246) were collected tumor regions segmented semi-automatically. A total 174 radiomics features extracted, subtypes identified validated by unsupervised analysis. gene-profile-based classifier was developed predict subtypes. The prognostic differences...
The five major RNA methylation modifications (m6A, m1A, m6Am, m5C, and m7G) exert biological roles in tumorigenicity immune response, mediated mainly by "writer" enzymes. Here, the prognostic values of enzymes TCP1 role drug resistance breast cancer (BC) were explored for further therapeutic strategies.We comprehensively characterized clinical, molecular, genetic features subtypes consensus clustering. modification "Writers" related genes_risk (RMW_risk) model BC was constructed via a...
Objective: The newly defined cancer-testis (CT) gene, MEIOB, was previously found to play key roles in DNA double-strand break(DSB) repair. In this study, we aimed investigate the effects and mechanisms of MEIOB carcinogenesis triple-negativebreast cancers (TNBCs). Methods: Cancer Genome Atlas database used quantify expression MEIOB. Cox regression analysis toevaluate association between prognosis human TNBC. on cell proliferationand migration TNBCs were also assessed vitro. Patient-derived...
Abstract Background Although neoadjuvant chemotherapy (NAC) is currently the best therapy for triple‐negative breast cancer (TNBC), resistance still occurs in a considerable proportion, thus it crucial to understand mechanisms and identify predictive biomarkers patients selection. Methods Biopsy samples were collected from 21 with TNBC who underwent NAC. Whole‐exome sequencing (WES), targeted sequencing, multiplex immunohistochemistry (mIHC) carried out on clinical used validate potential...
Abstract Background: Triple-negative breast cancer (TNBC) is a type of highly invasive with poor prognosis. According to new research, long noncoding RNAs (lncRNAs) play significant role in the progression cancer. Although lncRNAs has been well reported, few studies have focused on TNBC. This study aimed explore biological function and clinical significance forkhead box C1 promoter upstream transcript (FOXCUT) triple-negative Methods: Based bioinformatic analysis genome atlas (TCGA)...
Chemotherapy is a comprehensive therapy for breast cancer; nevertheless, its associated adverse effects are drawing increasing attention with the continuous improvement of efficacy. The changes in serum lipids cancer patients caused by chemotherapy have been reported previous studies, whereby former increase incidence rate cardiovascular disorders. However, variations different regimens seldom reported.From January 2011 to December 2017, 1740 treated were recruited at First Affiliated...