The 973 Program is China's keystone national research program established to support basic in natural and physical sciences. In addition promoting the development of core technology scientific infrastructure needed enable China meet social economic challenges 21st century, training mentoring new generation young scientists are also important objectives this program. green chemical pesticide a part Program. main stage 1 (2003−2008) establish capability conduct discovery "green" crop...

A novel and efficient method for the synthesis of (Z)-fluorinated alkenylboronic acid pinacol esters via Cu-catalyzed stereoselective borylation gem-difluoroalkenes using bis(pinacolato)diboron (B2pin2) as boron source with assistance NaOtBu Xantphos at room temperature was developed.

Abstract Inorganic nanoparticles (NPs) are promising drug delivery carriers owing to their high loading efficiency, scalable preparation, facile functionalization, and chemical/thermal stability. However, the clinical translation of inorganic nanocarriers is often hindered by poor biodegradability lack controlled pH response. Herein, a fully degradable pH‐responsive DOX@ACC/PAA NP (pH 7.4–5.6) developed encapsulating doxorubicin (DOX) in poly(acrylic acid) (PAA) stabilized amorphous calcium...

A robust copper-catalyzed or transition-metal-free cross-coupling of gem-difluoroalkenes with tertiary, secondary, and primary alkyl Grignard reagents has been developed. Remarkably, the tertiary secondary alkylation proceeded very smoothly in presence 25 mol % CuCN under conditions, affording alkyl-substituted fluoroalkenes good to excellent yields Z stereoselectivity.

A novel and efficient CuI-catalyzed synthesis of 2,3,5-trisubstituted furans was developed via coupling cyclization gem-difluoroalkenes with active methylene carbonyl compounds such as 1,3-dicarbonyl compounds, acetoacetonitrile, phenylsulfonylacetone the assistance a base. Commercial availability substrates or reagents, good to high isolated yields, excellent functional group compatibility make this transformation powerful tool for various furans. plausible mechanism involving allenyl...

An efficient method for the synthesis of 3-tertiary alkylated 1,1-difluorostyrene derivatives<italic>via</italic>Cu-catalyzed alkylation α-(trifluoromethyl)styrenes with tertiary alkylmagnesium reagents at room temperature was developed.

A mild and versatile method for the construction of C-N bonds by reaction (2,2-difluorovinyl)arenes with various N-H-containing heterocycles in presence K3PO4 has been developed. The proceeded efficiently at room temperature (25 °C) affording (E)-N-α-fluorovinyl derivatives azoles 3 good to excellent yields relatively high stereoselectivity.

A novel Kumada-Tamao-Corriu cross-coupling reaction of gem-di- or monofluoroalkenes with Grignard reagents, without β-hydrogen atoms, in the presence a catalytic amount palladium- nickel-based catalysts has been developed. The is performed under mild conditions (room temperature reflux diethyl ether for 1-2 h) and leads to di-cross- mono-cross-coupled products good high yields.

A novel green and efficient one-pot three-component synthesis of 2-aryl-pyridines in good to excellent yields has been reported. The methodology initially involved the formation 1,2-dihydropyridine intermediates via reaction a variety aromatic aldehydes with ethyl (methyl) acetoacetate ammonium acetate, which were same starting materials as Hantzsch reaction, under solvent-, catalyst- heat-free (at room temperature) conditions, followed by air oxidation for 72 hours. In this paper, we also...

An unprecedented highly stereoselective example of nickel-catalyzed Suzuki–Miyaura type cross-coupling reactions (2,2-difluorovinyl)benzene derivatives with arylboronic acids was developed.

A novel copper-free highly stereoselective cyanation of gem-difluoroalkenes by using benzyl nitrile as a cyanating reagent with the assistance tBuOLi under air atmosphere at room temperature was developed. variety versatile fluorinated alkenyl nitriles were obtained. The proposed mechanism involved C-H bond oxidation, C-CN cleavage, and then nucleophilic vinylic substitution (SN V).

A practical and convenient approach for the secondary C(sp3)–H arylation of diarylmethanes with various fluoroarenes is described. The reaction proceeds smoothly in presence LDA (lithium diisopropylamide) at room temperature affords triarylmethanes moderate to high yields.

The first example of direct hydrotrifluoromethylthiolation terminal alkynes in the presence AgSCF3 and K2S2O8 was established for synthesis a variety vinyl trifluoromethyl thioethers. anti-Markovnikov Markovnikov adducts were obtained moderate to good yields via two different reaction systems. Studies probe mechanism addition reactions including radical trapping experiments, kinetic isotope effect deuterated experiments determination H-sources conducted.

Traditional charge-conversion nanoparticles (NPs) need the breakage of acid-labile groups on surface, which impedes rapid response to acidic microenvironment. Here, we developed novel rodlike NPs with amphiphilic dextran-b-poly(lactic-co-glycolic acid), poly(2-(dimethylamino) ethylmethylacrylate)-b-poly(ε-caprolactone), and an aggregation-induced emission-active probe through flash nanoprecipitation (FNP). These exhibit reversible negative-to-positive charge transition at a slightly pH...

A mild and efficient DBN-mediated addition reaction of α-(trifluoromethyl)styrenes with diazoles, triazoles, tetrazoles, primary, secondary, secondary cyclic amines was developed. This practical protocol provided a robust method for the synthesis various β-trifluoromethyl nitrogen-containing heterocycles amines.

Abstract A simple and highly efficient approach for the hydrodefluorination of both fluoroarenes trifluorotoluenes in presence lithium triethylborohydride using a catalytic amount nickel(II) chloride (NiCl 2 , mol%) combined with bis(tricyclohexylphosphine)nickel(II) [NiCl (PCy 3 ) mol%] as cocatalyst has been developed.

Superkiller of CF bonds: Two new LiEt3BH/Ni-based catalyst systems for the hydrodefluorination (HDF) fluoroarenes and trifluorotoluenes were reported. Both reduced to corresponding arenes toluenes in excellent yields with LiEt3BH presence 40 % NiCl2, whereas a catalytic amount NiCl2(PCy3)2 (typically 5 mol %) along exhibited high activity selectivity HDF was inert trifluorotoluenes. Detailed facts importance specialist readers are published as ”Supporting Information”. Such documents...

A highly efficient Pd-catalyzed Sonogashira coupling of various aryl fluorides with terminal alkynes in the presence LiHMDS was developed. Both unreactive electron-rich fluoroarenes and electron-poor proceeded smoothly afforded corresponding internal moderate to excellent yields.