A5086123297- Magnetic properties of thin films
- Magnetic Properties and Applications
- Gut microbiota and health
- Aquaculture disease management and microbiota
- Cancer-related molecular mechanisms research
- Renal Diseases and Glomerulopathies
- High Altitude and Hypoxia
- Nonlinear Differential Equations Analysis
- Bone Metabolism and Diseases
- Rheumatoid Arthritis Research and Therapies
- Heme Oxygenase-1 and Carbon Monoxide
- RNA modifications and cancer
- Traditional Chinese Medicine Analysis
- Metallic Glasses and Amorphous Alloys
- Cancer, Hypoxia, and Metabolism
- Stock Market Forecasting Methods
- Liver Disease Diagnosis and Treatment
- Cytokine Signaling Pathways and Interactions
- Bone health and osteoporosis research
- Differential Equations and Numerical Methods
- Metabolomics and Mass Spectrometry Studies
- Takotsubo Cardiomyopathy and Associated Phenomena
- Natural product bioactivities and synthesis
- Inflammasome and immune disorders
- Domain Adaptation and Few-Shot Learning
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2025
Wangjing Hospital of China Academy of Chinese Medical Sciences
2022-2025
Southwest Medical University
2020-2024
Qilu Hospital of Shandong University
2024
Shandong University
2022-2024
Beihang University
2018-2024
Kunming University of Science and Technology
2022-2024
Institute of Informatics of the Slovak Academy of Sciences
2024
Shandong Normal University
2023-2024
Institute of Oceanology
2024
Imidacloprid (IMI) is among the common neonicotinoid insecticides used in agriculture worldwide, posing a potential toxic threat to non-target animals and humans. Numerous studies have shown that ferroptosis involved pathophysiological progression of renal diseases. However, it remains unclear whether IMI-induced nephrotoxicity. In present study, we investigated pathogenic role kidney damage vivo. Transmission electron microscopy (TEM) showed mitochondrial crest cells significantly decreased...
Environmental mercury is a concern for coastal ecosystem health, and exerts adverse effects on human health. Despite the growing body of evidence showing hepatoprotective roles curcumin mercury, knowledge between macroscopic descriptions actual mechanism(s) underlying these processes getting larger remains elusive. Herein, mice received single injection mercuric chloride (HgCl2) (5 mg/kg weight) and/or (50 mg/kg, weight, p.o.). Firstly, results showed could decline HgCl2-induced up-regulated...
Growing evidence shows that C-Type Lectin Domain Containing 7A (Clec7a) may be involved into neuroinflammatory injury of various neurological diseases. However, its roles in neuropathic pain remain unclear.A chronic constriction (CCI) rat model was constructed, and gene expression profilings spinal cord tissues CCI-insulted rats were detected by both microarray RNA-seq studies. A series bioinformatics analyses identified C/EBPβ-Clec7a to a candidate axis pain. Then, mechanical allodynia,...
TFRD has been widely used in China to treat osteoporosis (OP). However, the specific molecular mechanism of against OP not fully clarified. Our previous studies have also proved that could attenuate and clinical equivalent dose 67.5mg/kg/d is effective for treating OP. Therefore, this study 67.5mg/kg as dosage combination with multi omics investigate action treatment The aim was further elucidate based on metagenomic metabolomic analyses. In study, hematoxylin-eosin (H&E) staining, micro...
Shaoyao Gancao Decoction (SGD) is a classic and representative oral administration of traditional Chinese medicine formula. It composed two herbal medicines, Paeoniae Radix Alba [Paeonia lactiflora Pall] Glycyrrhizae et Rhizoma. The clinical study found SGD could effectively reduce symptoms improve the level inflammation in osteoarthritis (OA) patients. aim this to identify efficacy molecular mechanism treatment OA, find new therapeutic target through RNA sequencing (RNA-Seq) provide...
This study was first and systematically conducted to evaluate the hypoxia response of brain, heart, lung, liver, kidney mice exposed an animal hypobaric chamber. First, we examined pathological damage above tissues by Hematoxylin & eosin (H&E) staining. Secondly, biochemical assays were used detect oxidative stress indicators such as superoxide dismutase (SOD), malondialdehyde (MDA), reduced glutathione (GSH), oxidized (GSSG). Finally, compensation mechanism evaluated expression levels...
Abstract Pancreatic cancer (PaCa) is one of the most fatal malignancies digestive system, and patients are diagnosed at advanced stages due to lack specific effective tumor-related biomarkers for early detection PaCa. miR-492 has been found be upregulated in PaCa tumor tissue may serve as a potential therapeutic target. However, molecular mechanisms by which promotes growth progression unclear. In this study, we first that enhancer loci activated neighboring genes (NR2C1/NDUFA12/TMCC3)...
This study explored the effects of butylated hydroxytoluene (BHT) and ethoxyquin (EQ) ethyl ether extracts, acetate extracts (EAE), acetone ethanol aqueous Ginkgo biloba leaves (EGbs) on lipid oxidation in a linoleic acid emulsion, fish flesh feed hydroxyl radical (·OH)-treated carp erythrocytes. The acid, were incubated with BHT, EQ EGbs at 45°C for 8 d, respectively, except control group. was then measured by ferric thiocyanate method or thiobarbituric method. erythrocytes treated presence...
Mercury is a naturally occurring element and highly toxic to humans even at low dosage. Curcumin polyphenol found in turmeric (Curcuma longa), widely used as treatment strategy improve antioxidant anti-inflammatory properties. The purpose of this study was investigate the potential protective mechanisms curcumin spleen damage induced by HgCl2. mice were given intragastric administration 2 h before HgCl2 injection for 24 h. At first, splenic transcriptome analysis showed that 3334 genes (2134...
Manganese (Mn) toxicity-induced leaf chlorosis limits crop production in acidic soils, but its underlying mechanisms remain unknown. The effects of excessive Mn on chlorophyll (Chl) biosynthesis sugarcane (Saccharum officinarum L.) leaves were investigated. Under treatment, Chl concentration decreased with accumulation and appeared expanding leaves. Before that, levels the initial precursor 5-aminolevulinic acid (ALA) downstream intermediates decreased, whereas magnesium-protoporphyrin IX...
BACKGROUND:In this study, we investigated the potential neuroprotective effect of oleuropein (OLE) on apoptotic changes via modulating Akt/glycogen synthase kinase 3 beta (Akt/GSK-3b) signaling in a rat model cerebral ischemia/reperfusion injury (IRI). MATERIAL AND METHODS:Sprague-Dawley male rats (12 weeks, n=200) were randomly assigned to 5 groups: sham group, vehicle (IRI+ vehicle) OLE (IRI+OLE) OLE+LY294002 (IRI+OLE+LY294002) and LY294002(IRI+LY294002) group. The subjected (IRI) treated...
A series of Er3+- and Yb3+-doped K2LaNb5O15 (KLN:xEr3+/Yb3+) up-conversion (UC) submicro-particles have been synthesized for the first time by a simple low-cost molten salt (MS) approach. X-ray diffraction (XRD) was performed to analyze phase structure, prepared KLN:xEr3+/Yb3+ samples exhibited single tetragonal tungsten bronze (TTB) structure. The morphologies were characterized scanning electron microscopy (SEM), submicro-rod-like particles obtained all samples. Under 980 nm excitation,...
Extensive use of neonicotinoids insecticides (NNIs) rapidly garnered widespread attention in the toxicology, since they have been found human samples, including urine, blood, breast milk and hair. However, precise mechanism is not completely clear regarding NNIs-induced hepatotoxicity. In this study, we exposed male mice to three (dinotefuran (DIN), nitenpyram (NIT) acetamiprid (ACET) for 30 days. Our results showed that NNIs remarkably induced morphological damage liver. Simultaneously,...
L. lactis KUST48 ( LLK48 ) with a bacteriostatic effect against S. agalactiae was isolated from tilapia intestinal tracts. infection significantly reduced the relative abundance of bacteria and various physiological functions in zebrafish intestines. demonstrated subsequent therapeutic effects on intestine. Therefore, potential probiotic can be considered as treatment for infections aquaculture, which reduce use antibiotics help maintain fish health.